A Systematic Review of the Effects of Lamotrigine on Cognitive Function and Quality of Life

Aldenkamp, Albert P.; Baker, Gus A.

doi:10.1006/ebeh.2001.0168

Cited by 73 publications

(53 citation statements)

References 30 publications

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“…An examination of the incidence of extrapyramidal side effects in patients given lamotrigine in addition to their antipsychotic drug may be worthwhile, since there are hints that lamotrigine has some benefit in the treatment of Parkinson's disease (Zipp et al 1995), although significant improvements in motor function have not been observed (Zipp et al 1995;Shinotoh et al 1997). An open-label study in patients diagnosed with Alzheimer's disease showed some treatment improvement in depressed mood, word recognition, and naming with lamotrigine treatment (Tekin et al 1998), and lamotrigine may have a beneficial effect on cognition in patients with epilepsy (Aldenkamp and Baker 2001). Furthermore, healthy volunteers on low doses of lamotrigine showed improvement on measures of cognitive activation and alertness (Aldenkamp et al 2002).…”

Section: Interactions With Antipsychotic Drugsmentioning

confidence: 97%

The potential role of lamotrigine in schizophrenia

2005

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The efficacy of lamotrigine is most likely explained within the framework of a glutamate neuron dysregulation hypothesis, and may arise primarily through the drugs ability to influence glutamate transmission and neural activity in the cortex. The drug is likely to act through inhibition of voltage-gated sodium channels, though other molecular interactions cannot be ruled out. Lamotrigine may add to or synergise with some atypical antipsychotic drugs acting on glutamate transmission; alternatively, they may act independently on glutamate and dopamine systems to bring about a combined therapeutic effect. We propose new strategies for the treatment of schizophrenia using a combination of anti-dopaminergic and anti-glutamatergic drugs.

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Section: Interactions With Antipsychotic Drugsmentioning

confidence: 97%

The potential role of lamotrigine in schizophrenia

2005

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“…Anti-epileptics such as lamotrigine do not primarily act on GABAergic transmission, and thus may be associated with lesser cognitive and behavioural impairments (Aldenkamp 2005). Lamotrigine is reported also to have antidepressant effects and has been associated with improvements in health-related quality of life factors (perceived cognitive abilities, dysphoria and tiredness) (Aldenkamp 2001b).…”

Section: Anti-epileptic Drugsmentioning

confidence: 99%

Neurocognitive problems in epilepsy

Lodhi¹,

Agrawal²

2012

Adv. psychiatr. treat

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SummaryCognitive dysfunction is one of the major contributors to the burden of epilepsy. It can significantly disrupt intellectual development in children and functional status and quality of life in adults. Epilepsy affects cognition through a number of mechanisms in complex interrelationship. Cognitive deficits in epilepsy may be treated indirectly through aggressive seizure control using anti-epileptic drugs or surgery, and by treating comorbid conditions such as depression. The beneficial effects of reducing seizures may offset the adverse cognitive side-effects of these therapies. Direct treatment of cognitive impairment in epilepsy mainly involves memory rehabilitation. Other direct treatments are mostly experimental and their evidence base is currently poor.

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“…Subsequently, two larger 12-week, double-blind placebo controlled trials with add-on lamotrigine failed to demonstrate efficacy on their primary endpoint (change in the Positive and Negative Symptom Scale) but did find evidence for improvement in cognitive symptoms (Goff et al, 2007). Consistent cognitive benefit has previously been attributed to lamotrigine in patients with epilepsy (Aldenkamp and Baker, 2001). A large placebo response in the schizophrenia trials may have compromised their overall sensitivity, and the need for a 6-week dose titration with lamotrigine to lower the risk of rash may also have reduced the likelihood of separating from placebo over the relatively short trial period.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia

Large¹,

Bison²,

Sartori³

et al. 2011

J Pharmacol Exp Ther

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Sodium channel inhibition is a well precedented mechanism used to treat epilepsy and other hyperexcitability disorders. The established sodium channel blocker and broad-spectrum anticonvulsant lamotrigine is also effective in the treatment of bipolar disorder and has been evaluated in patients with schizophrenia. Double-blind placebo-controlled clinical trials found that the drug has potential to reduce cognitive symptoms of the disorder. However, because of compound-related side-effects and the need for dose titration, a conclusive evaluation of the drug's efficacy in patients with schizophrenia has not been possible. In this series of studies in the rat, we compared the efficacy of the two new molecules to prevent a cognitive deficit induced by the N-methyl-D-aspartic acid receptor antagonist phencyclidine (PCP) in the reversal-learning paradigm in the rat. We also explored the effects of the drugs to prevent brain activation and neurochemical effects of PCP. We found that, like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication.

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A Systematic Review of the Effects of Lamotrigine on Cognitive Function and Quality of Life

Cited by 73 publications

References 30 publications

The potential role of lamotrigine in schizophrenia

The potential role of lamotrigine in schizophrenia

Neurocognitive problems in epilepsy

The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia

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