A systematic review of the epidemiology, disease characteristics and management of systemic sclerosis in Australian adults

Morrisroe, Kathleen; Stevens, Wendy; Proudman, Susanna; Nikpour, Mandana

doi:10.1111/1756-185x.13203

Cited by 16 publications

(15 citation statements)

References 72 publications

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“…The association of ATA and ILD was reported globally among Asian, European, Australian, and North American population. 19,[38][39][40] Nonetheless, this association was not detected in certain other countries including Brazil which is also probably linked to a low number of cases. 41 Moreover, ATA was not correlated in either population with lung involvement severity measured by FVC in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the previous cohort-based studies reported that the lcSSc constitute more than half of the patients and the dcSSc percentage was in a range of 18% (Sweden) to 38% (Singapore). 6,7,13,15,16,18,19 Nonetheless, data from data from Chinese and Thai cohorts reported the prevalence of 59.7% and 68.6% for dcSSc, respectively. 20,21 The higher rate of dcSSc in Iranian patients compared to most of the Asian studies can be either due to referral bias or due to genetic variations that need to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Allanore

Gharibdoost

Jamshidi

et al. 2018

Journal of Scleroderma and Related Disorders

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Objectives: Systemic sclerosis is a severe and rare chronic auto-immune multisystem disorder characterized by vasculopathy and skin stiffness. Ethnic and geographical origin can influence the outcomes. In this study, we compared the phenotypic characteristics of Iranian and French patients. Methods: This cross-sectional study was performed on 200 Iranian and 268 French systemic sclerosis patients. Iranian patients collected from the Iranian systemic sclerosis cohort of the Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences. The French population was monocentric, and it was constituted by the patients included locally in the EUSTAR database in December 2016. Results: The mean age at onset was significantly lower in Iranian patients (35.58 ± 11.68 vs 47.06 ± 13.54, p-value < 0.001). The female-to-male ratio was approximately 5.2:1 and was not different in the two populations. The prevalence of diffuse cutaneous systemic sclerosis was significantly higher in Iranian patients (60.2% vs 42.85%, p-value < 0.001). Calcinosis cutis and joint synovitis were more prevalent in French patients (p-value = 0.013, <0.001). The positivity of anti-topoisomerase antibody was higher in Iranian patients, whereas the anti-centromere antibody predominated in French cases (p-value < 0.001). Restrictive pattern of pulmonary function test was more common in Iranian patients (p-value < 0.001), while estimated pulmonary arterial pressure by echocardiography was higher in French patients (p-value < 0.001). Conclusion: It seems that systemic sclerosis occurred in younger ages among Iranian female with the predominance of diffuse cutaneous subtype. In addition, lung interstitial disease appeared to be more prevalent and severe in Iranians than French patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Allanore

Gharibdoost

Jamshidi

et al. 2018

Journal of Scleroderma and Related Disorders

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“…12 Another study that yielded similar results is the one conducted in Lugo, Spain, with a global prevalence of 27.7 per 100,000 inhabitants, 77% females. 13 A review made in Australia by Morrisroe et al 14 showed a prevalence of 23.3-86 per 100,000 inhabitants, with female predominance, with a maximum female:male ratio of 5:1. In Detroit (USA), a prevalence of 27.6 per 100,000 inhabitants was estimated, being more frequent in women than in men, with a 4.6:1 ratio.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of systemic sclerosis in Colombia: Data from the National Health Registry 2012–2016

Fernández-Ávila

Bernal-Macías

Gutiérrez

et al. 2019

Journal of Scleroderma and Related Disorders

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Introduction: Systemic sclerosis is an autoimmune disease that characteristically presents with fibrosis and vasculopathy. In Latin America, the information on the epidemiology of this disease is scarce and records are essential to know its behavior in the populations. In Colombia, the Ministry of Health uses the SISPRO tool to collect information on the unified national health system which offers nearly universal coverage (around 95%). This public information makes it possible to perform epidemiological studies on different diseases. Objectives: Using the SISPRO data corresponding to the years 2012–2016, we analyzed the prevalence and characteristics of patients with systemic sclerosis. Methods: A descriptive cross-sectional study was performed based on the SISPRO data; we used as keywords the diagnoses of the International Classification of Diseases related to the diagnosis of systemic sclerosis. Results: A total of 11,300 individuals diagnosed with systemic sclerosis were documented. The estimated prevalence was 23.7 cases per 100,000 inhabitants (based on a total population of 47,663,162); this disease is more frequent in the age group of 65–69 years in females (77%), and has a female:male ratio of 3.27:1. Conclusion: This study describes the epidemiological characteristics of systemic sclerosis in Colombia, based on official statistics from the Ministry of Health. The results provide a new vision of this disease in Latin America and open the door to future research, in order to better understand the particular characteristics of this disease in our country and our region.

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“…Interstitial lung disease occurs in more than half of SSc patients, with the symptoms ranging from subclinical lung involvement to major pulmonary disease progressing and even respiratory failure 11,12 . Pulmonary arterial hypertension and hypertensive renal crisis are also commonly found in patients with SSc 13 . Malignancies are reported at an increased rate, but the magnitude of this risk and the type of cancer vary 14…”

Section: Introductionmentioning

confidence: 99%

The economic burden of systemic sclerosis—A systematic review

Chen

Hernández‐Muñoz

et al. 2021

Int J of Rheum Dis

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Aim Systemic sclerosis (SSc) is a rare, chronic autoimmune disease associated with a substantial economic burden. This study aimed to assess the costs associated with SSc and to identify major cost drivers. Methods A systematic search was conducted in MEDLINE and Embase to identify relevant studies. Two independent reviewers evaluated studies based on inclusion/exclusion criteria and performed data extraction. Costs were converted into 2017 US dollars by purchasing power parity. The review was conducted following the Preferred Reporting Items for Systematic Review and Meta‐analysis (PRISMA) guideline. Results The original literature search identified 113 potentially relevant citations, of which 10 articles met all the inclusion/exclusion criteria and were included in the data extraction and analysis. The identified studies evaluated costs associated with SSc in 11 countries from North America, Europe, and Australia published between 2009 and 2018. Eight studies reported direct costs and seven studies reported indirect costs. Direct costs varied from $3356 (Hungary) to $27 032 (Germany) with hospitalization and medication being two of the biggest components of direct medical costs in most studies. The indirect costs for lost productivity varied from $2433 (Italy) to $20 663 (UK), accounting for a significant portion of the total economic burden. Conclusions Large variations existed in annual costs of SSc, but all studies found that SSc imposed a substantial economic burden on patients and their families. The identified studies were mostly from high‐income countries and there is still a knowledge gap regarding the cost of SSc in other parts of the world.

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A systematic review of the epidemiology, disease characteristics and management of systemic sclerosis in Australian adults

Cited by 16 publications

References 72 publications

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Prevalence of systemic sclerosis in Colombia: Data from the National Health Registry 2012–2016

The economic burden of systemic sclerosis—A systematic review

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