A systematic review of diffusion tensor imaging studies in obesity

Okudzhava, Liana; Heldmann, Marcus; Münte, Thomas F.

doi:10.22541/au.161946638.86201784/v1

Cited by 1 publication

(4 citation statements)

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“…A primary finding of this study is a significant association between body fat and DTI-based white-matter microstructural integrity. This is consistent with accumulating recent reports of visceral obesity being linked to poor white-matter health in otherwise healthy adults (11, 12, 77, 78). The affected tracts, including the genu of corpus callosum, forceps minor, pontine crossing tract (a part of MCP), corticospinal tract, cerebral peduncle, right anterior thalamic radiation, and right superior corona radiata, are associated with reward processing (79), inhibitory control (80), sensory integration (81) and memory (81, 82).…”

Section: Discussionsupporting

confidence: 93%

“…The affected tracts, including the genu of corpus callosum, forceps minor, pontine crossing tract (a part of MCP), corticospinal tract, cerebral peduncle, right anterior thalamic radiation, and right superior corona radiata, are associated with reward processing (79), inhibitory control (80), sensory integration (81) and memory (81, 82). Nonetheless, there remains substantial variability in the existing literature, in part due to BMI and WHR being used as surrogates of adiposity in the majority of cases (12). While these prior studies found FA to be significantly negatively associated with metrics of obesity, the AFR-FA association is just below the threshold of significance in this study, the same negative relationship can be observed (see Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is associated with excessive accumulation of adipose tissue, and has also been variably associated with reduced cortical volume, more strongly in frontal regions and less so in occipital and temporal regions (10). Furthermore, visceral obesity has recently been linked to poor white-matter microstructural health in otherwise healthy adults, as reflected by MD and FA (11) (see recent review by Okudzhava et al (12)). Moreover, the incidence of non-alcoholic fatty-liver disease, which is closely related to obesity, has been linked with smaller total cerebral brain volumes.…”

Section: Introductionmentioning

confidence: 99%

“…However, the contribution of obesity to dementia in aging older adults remains unclear (7, 14, 15), partially driven by the large variation in the metrics used to quantify obesity, ranging from body-mass index (BMI) to waist-to-hip ratio (WHR). Though used in the majority of studies addressing obesity and white-matter microstructure (12), these metrics cannot be equated to level of adiposity.…”

Section: Introductionmentioning

confidence: 99%

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Is adiposity associated with white-matter microstructural health and intelligence differently in men and women?

Patel

Chad

Chen

2022

Preprint

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The role of vascular risk factors in age-related brain degeneration has long been the subject of intense study. As its own sub-category of vascular risk, obesity has an increasingly recognized role in influencing brain health and health-care strategies, but its association with brain health remains under-studied. Notably, no prior study has addressed sex differences in the association between metrics of obesity and white-matter microstructural integrity, an important early marker of brain degeneration, despite known sex differences in fat storage and usage. This study focuses on the associations between markers of body fat (abdominal fat ratio: AFR, and liver proton density fat fraction: PDFF) and brain microstructural health (measures of white-matter microstructure using diffusion-tensor imaging, DTI). We found that fluid intelligence and reaction time are indeed associated with body fat differently in men and women. We also found significant differences in the associations of AFR with DTI metrics between sexes. These sex differences are mirrored in the associations of SBP and age with DTI metrics. Moreover, these sex differences in the AFR and SBP associations with DTI metrics persist when controlling for age. Taken together, these findings suggest that there are inherent sex-driven differences in how brain health is associated with vascular risk factors such as obesity.

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