A Systematic Review of Autologous Transplantation Methods in Vitiligo

Njoo, M. D.; Westerhof, W.; Bos, J. D.; Bossuyt, Patrick M.

doi:10.1001/archderm.134.12.1543

Cited by 163 publications

(192 citation statements)

References 42 publications

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“…Based on published reports, the STSG technique has the highest pooled success rate of 87%. 45 Additionally, BG has a repigmentation rate ranging from 80 to 90%. 14,16,17 PG is no longer recommended as it has the highest rate of adverse effects and poor cosmetic results.…”

Section: Discussionmentioning

confidence: 99%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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SummaryBackground Vitiligo is a disfiguring disease, characterized frequently by the presence of de-pigmented macules and/or patches. Traditional therapies are essentially medical and are most preferred by dermatologists. Surgical therapies, however, are amongst the most effective interventions for vitiligo but are limited by their invasive nature, as well as the training and expertise needed to perform specific procedures. Objectives To assess the evidence for the effectiveness, safety and applicability of the various surgical methods in the treatment of vitiligo. Methods For this systematic review of vitiligo surgical therapies, our searches included: PubMed, MEDLINE and Cochrane databases. Results We reviewed research studies reporting on split thickness skin grafts (STSG), punch/mini-graft, blister roof grafting, cultured and non-cultured cellular transplantation (MKTP). While all methods vary in their repigmentation outcomes, STSG is found to have the highest repigmentation success rate. Overall, post-operative complications included milia, scarring, cobblestone appearance or hyperpigmentation of treated areas. Conclusion This review highlights the need for more randomized controlled trials in this field, underpinned by a more standardized objective approach to the assessment of repigmentation following surgical interventions.

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Section: Discussionmentioning

confidence: 99%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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“…Available techniques are split-thickness grafting, epidermal blister grafting, cultured or non-cultured melanocyte (epidermal suspension) grafting and punch grafting (3,4). The punch grafting technique is a safe, simple and cheap technique, and therefore widely available and much used (3)(4)(5)(6)(7). In punch grafting, grafts are punched out from normally pigmented donor sites and are transplanted into depigmented recipient sites from which similar punch grafts have been removed previously (8).…”

Section: Introductionmentioning

confidence: 99%

“…In punch grafting, grafts are punched out from normally pigmented donor sites and are transplanted into depigmented recipient sites from which similar punch grafts have been removed previously (8). Large grafts (>2 mm) have high risks on side effects like cobblestone formation (3,4,7,9). Hence, the current technique involves 1-to 1.5-mm superficial punch grafts, depending on anatomical location (10).…”

Section: Introductionmentioning

confidence: 99%

Optimising size and depth of punch grafts in autologous transplantation of vitiligo and piebaldism: a randomised controlled trial

Komen

Vrijman

Prinsen

et al. 2016

Journal of Dermatological Treatment

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Background: To date, autologous punch grafting appears to be the easiest and least expensive surgical technique for stable vitiligo and piebaldism. Punch grafting is available worldwide, with no need for specialised instruments. However, no reliable data on efficacy and safety of different punch depths and punch sizes are available. Objective/methods: To compare the efficacy and safety of different punch depths and punch sizes in autologous punch grafting, a randomised controlled trial was performed in 33 patients with vitiligo or piebaldism. In each patient, four depigmented regions were allocated to: 1.5 mm deep grafts, 1.5 mm superficial grafts, 1.0 mm deep grafts, and 1.0 mm superficial grafts. Primary outcome was the total pigmented surface area. Secondary outcomes were Patients Global Assessment (PGA) and side effects. Results: Six months after grafting, 1.5 mm grafts showed a significantly larger pigmented surface area compared to 1.0-mm grafts (p < 0.001), though more side effects as well. No significant differences in the total pigmented surface between different punch depths were found. Deep grafts showed more erythema compared to superficial grafts. Conclusion: We recommend 1.5 mm superficial grafts in autologous punch grafting for trunk and proximal extremities in patients with stable vitiligo and piebaldism.

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“…2 This can be carried out by either culture or non culture techniques, each having its advantages and disadvantages. 3,4 We undertook this study to compare the two methods of melanocyte transplantation in stable vitiligo, namely melanocyte rich cell suspension and cultured melanocyte transfer for replenishing melanocytes.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of efficacy of cultured versus non cultured melanocyte transfer in the management of stable vitiligo

Verma

Grewal²,

Chatterjee

et al. 2014

Medical Journal Armed Forces India

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Melanocyte rich cell suspensionMelanocyte culture Vitiligo a b s t r a c t Background: Replenishing melanocytes by autologous melanocytes selectively in vitiliginous macules is a novel and promising treatment. With expertise in culturing autologous melanocytes, it has now become possible to treat larger recipient areas with smaller skin samples.To determine the relative efficacy of cultured versus non cultured melanocyte transfer in the management of stable vitiligo. Methods: The melanocytes were harvested as an autologous melanocyte rich cell suspension from a donor split thickness graft. Cultured or non cultured melanocytes were then transplanted to the recipient area that had been superficially dermabraded. 100 patches of vitiligo in patients reporting to this hospital were randomly allocated into 2 groups to receive either of the interventions. Results: An excellent response was seen in 62.17% cases with the autologous melanocyte rich cell suspension technique and in 52% with the melanocyte culture technique. Conclusion: Autologous melanocyte transplantation can be an effective form of surgical treatment in stable but recalcitrant lesions of vitiligo. Large areas of skin can be covered with a smaller donor skin using melanocyte culture technique; however culture method is more time consuming, and a labour intensive process, requiring state of the art equipments with a sterile lab setup. Available online at www.sciencedirect.com jo urn al ho mep age: www .e lsev ie r. co m/ lo cate/ mj afi m e d i c a l j o u r n a l a r m e d f o r c e s i n d i a 7 0 ( 2 0 1 4 ) 2 6 e3 1

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A Systematic Review of Autologous Transplantation Methods in Vitiligo

Cited by 163 publications

References 42 publications

Surgical interventions for vitiligo: an evidence-based review

Surgical interventions for vitiligo: an evidence-based review

Optimising size and depth of punch grafts in autologous transplantation of vitiligo and piebaldism: a randomised controlled trial

A comparative study of efficacy of cultured versus non cultured melanocyte transfer in the management of stable vitiligo

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