A systematic approach for designing a HBM Pilot Study for Europe

Becker, Kerstin; Seiwert, Margarete; Casteleyn, Ludwine; Joas, Reinhard; Joas, Anke; Biot, Pierre; Aerts, Dominique; Castaño, Argelia; Esteban, Marta; Angerer, Jürgen; Koch, Holger M.; Schoeters, Greet; Hond, Elly Den; Sepai, Ovnair; Exley, Karen; Knudsen, Lisbeth E.; Horvat, Milena; Bloemen, Louis; Kolossa-Gehring, Marike

doi:10.1016/j.ijheh.2013.07.004

Cited by 65 publications

(45 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The UK DEMOCOPHES pilot study protocol was based on the COPHES common European pilot study protocol with slight modifications (as listed below); discussion of the approach for designing the study has been published (Becker et al 2013). The pilot study was cross-sectional in design and participating countries could recruit via population registries or by schools.…”

Section: Methodsmentioning

confidence: 99%

Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK

Exley

Aerts

Biot

et al. 2015

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

Exposure to a number of environmental chemicals in UK mothers and children has been assessed as part of the European biomonitoring pilot study, Demonstration of a Study to Coordinate and Perform Human Biomonitoring on a European Scale (DEMOCOPHES). For the Europeanfunded project, 17 countries tested the biomonitoring guidelines and protocols developed by COPHES. The results from the pilot study in the UK are presented; 21 school children aged 6-11 years old and their mothers provided hair samples to measure mercury and urine samples, to measure cadmium, cotinine and several phthalate metabolites: mono(2-ethyl-5-hydroxyhexyl)phthalate (5OH-MEHP), mono(2-ethyl-5-oxoh e x y l ) p h t h a l a t e ( 5 o x o -M E H P ) a n d m o n o ( 2 -ethylhexyl)phthalate (MEHP), mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-benzyl phthalate (MBzP) and mono-n-butyl phthalate (MnBP). Questionnaire data was collected on environment, health and lifestyle. Mercury in hair was higher in children who reported frequent consumption of fish (geometric mean 0.35 μg/g) compared to those that ate fish less frequently (0.13 μg/g, p=0.002).Cadmium accumulates with age as demonstrated by higher levels of urinary cadmium in the mothers (geometric mean 0.24 μg/L) than in the children(0.14 μg/L). None of the mothers reported being regular smokers, and this was evident with extremely low levels of cotinine measured (maximum value 3.6 μg/L in mothers, 2.4 μg/L in children). Very low levels of the phthalate metabolites were also measured in both mothers and children (geometric means in mothers: 5OH-Responsible editor:

show abstract

Section: Methodsmentioning

confidence: 99%

Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK

Exley

Aerts

Biot

et al. 2015

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recruitment and sampling were closely connected with the Danish part of DEMOCOPHES, a project demonstrating the feasibility of a coordinated approach on human biomonitoring at the European level by examining levels of chemicals (mercury, cadmium, phthalates and cotinine) in comparable populations of schoolchildren and their mothers in 17 European countries [13,14]. In Denmark, the scenario was expanded to also include analysis of additional non-persistent chemicals as well as persistent chemicals and effect biomarkers in supplementary blood samples.…”

Section: Methodsmentioning

confidence: 99%

PCB Concentrations and Dioxin‐like Activity in Blood Samples from Danish School Children and Their Mothers living in Urban and Rural Areas

Mørck

Erdmann

Long

et al. 2014

Basic Clin Pharma Tox

Self Cite

View full text Add to dashboard Cite

Human exposure to persistent organic pollutants (POPs) is of major concern due to a diversity of adverse effects from prolonged exposure and bioaccumulation. Manufacturing of polychlorinated biphenyls (PCBs), a subgroup of POPs, has been prohibited for many decades; however, human exposure still occurs due to the persistent nature of the chemicals. The concentrations of the dioxin-like PCB congeners 105, 118 and 156 and the non-dioxin-like PCB congeners 28, 52, 101, 138, 153 and 180, pHCB and b-HCH as well as the dioxin-like activity using the AhR transactivity assay were analysed in blood samples from Danish schoolchildren and their mothers in the European framework of the DEMOCOPHES/COPHES projects. The participants were selected from an urban and a rural area, respectively. The PCB concentrations and the AhR-TEQ (TCDD toxic equivalent) were significantly higher in schoolchildren living in the urban area compared with the rural, and for AhR-TEQ, a strong correlation between the mothers and children was observed. We found a significant negative correlation between BMI and PCB concentrations in the children. Finally, in the mothers, there was a positive association between age and PCB concentration. These results show that both PCBs and dioxin-like activity can be measured as biomarkers of exposure and effects in blood samples from children and women. The results indicate that people living in urban areas may be exposed to higher concentrations of PCBs, dioxins and dioxin-like chemicals, which may lead to a greater risk of adverse effects for urban populations.

show abstract

“…The recruitment of participants and collection of samples followed the COPHES/DEMOCOPHES developed protocol (21). In Denmark, children aged 6-11 years and their mothers were recruited via local schools in the selected areas representing rural (Viby Sjaelland) and urban (Gentofte) communities.…”

Section: Recruitmentmentioning

confidence: 99%

Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Knudsen

Hansen

Mizrak

et al. 2017

Reviews on Environmental Health

Self Cite

View full text Add to dashboard Cite

AbstractBackground:The Danish part of the large European Human biomonitoring pilot project Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) investigated the urine, hair and blood concentrations of 66 different environmental chemicals in a group of 145 Danish school children aged 6–11 years and their mothers from rural and urban areas in autumn 2011. Some – but not all – results were published; however, the concurrence of the chemicals has not been assessed.Methods:The measured concentrations of polybrominated diphenyl ethers (PBDEs) and glyphosate is assessed to complete the investigation of all 66 chemicals in DEMOCOPHES. The concentrations of PBDEs were measured in plasma samples of 143 mothers and 116 children. Glyphosate was measured in a subsample of 27 urine samples. Previously assessed chemicals were polychlorinated biphenyls (PCBs), and polyfluoroalkyl substances (PFASs) analyzed in blood samples, mercury analyzed in hair, and phthalate metabolites, parabens, phenols, cadmium, paracetamol and cotinine analyzed in urine samples. Differences in concentrations between mothers and children were assessed, and the associations between the concentrations of the different environmental chemicals. investigated by correlation analysis.Results:PBDE47 was found in relatively high levels compared with previous Danish results in both mothers and children, with a significantly higher level in the children compared to their mothers. Glyphosate in concentrations around 1 ng/mL was detected in all 27 samples. The analyzed environmental exposures seem to follow a pattern where chemicals within the same classes are strongly correlated and where children and mothers are exposed to the same chemicals.Conclusion:The correlations between the measured environmental chemicals indicate that a specific exposure pattern may exist, where people who are highly exposed to one class of environmental chemicals also may be highly exposed to certain other classes. As some of the compounds were measured in higher levels in children compared to mothers, increased focus also on the exposure in young children is recommended. For more detailed investigation of specific exposure sources more studies with increased power and detailed questionnaires should be developed.

show abstract

A systematic approach for designing a HBM Pilot Study for Europe

Cited by 65 publications

References 26 publications

Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK

Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK

PCB Concentrations and Dioxin‐like Activity in Blood Samples from Danish School Children and Their Mothers living in Urban and Rural Areas

Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Contact Info

Product

Resources

About