A suspected case of malignant hyperthermia that was successfully treated with dantrolene administration via nasogastric tube

Kang, Bong Jin; Song, Jaegyok; Kim, Seok-Kon; Yoo, Jin Hee

doi:10.4097/kjae.2012.63.4.378

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Cited by 4 publications

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“…Use of oral dantrolene in MH has been reported anecdotally. [ 30 31 32 ] Oral dantrolene sodium is well absorbed and achieves peak blood levels 3–6 h after ingestion. [ 33 ] Oral dantrolene 5 mg/kg (divided 3–4 times a day) can attain acceptable plasma level of the drug.…”

Section: Discussionmentioning

confidence: 99%

Rare postoperative delayed malignant hyperthermia after off-pump coronary bypass surgery and brief review of literature

Raut¹,

Kar²,

Maheshwari³

et al. 2016

Ann Card Anaesth

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Postoperative malignant hyperthermia (MH) is a very rare phenomena. It is generally observed within less than an hour after discontinuation of the anesthetic trigger. Present case describes rare delayed postoperative presentation of MH after off-pump coronary bypass surgery. Prompt recognition and immediate treatment with dantrolene can effectively treat the fatal syndrome. Family education and genetic counseling should be encouraged.

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Section: Discussionmentioning

confidence: 99%

Rare postoperative delayed malignant hyperthermia after off-pump coronary bypass surgery and brief review of literature

Raut¹,

Kar²,

Maheshwari³

et al. 2016

Ann Card Anaesth

View full text Add to dashboard Cite

show abstract

“…Oral dantrolene has been administered through a nasogastric tube when intravenous dantrolene was not available. One patient was treated with 4 mg/kg of dantrolene as a suspension in 50 mL sterile water given twice within 30 min [110]. This technique should be used only as a last resort since dantrolene's absorption may be erratic, and the onset of action will be delayed.…”

Section: Administrationmentioning

confidence: 99%