1984
DOI: 10.1001/archderm.120.2.210
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A survey of cutaneous neural lesions for the presence of myelin basic protein. An immunohistochemical study

Abstract: The presence of myelin basic protein (MBP) within a skin neoplasm would support its derivation from Schwann's cells, since this substance is routinely present within Schwann's cells in the peripheral nervous system. Using a monoclonal antibody prepared against MBP and an unlabeled antibody peroxidase-antiperoxidase assay, we surveyed a variety of skin lesions suspected of being derived from Schwann's cells to determine whether MBP was present. Myelin basic protein was detected within the cytoplasm of cells com… Show more

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Cited by 11 publications
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“…2) Myelinization. Whereas an immunologic reaction to MBP is widely accepted as evidence of myelinization in Schwann cells, the utilization of Leu-7 antigen as a marker for Schwann cells is relatively recent (14,15). Besides the similar semiquantitative A B expression, there was also a similar distribution pattern and labeling intensity of these antigens.…”
Section: Discussionmentioning
confidence: 97%
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“…2) Myelinization. Whereas an immunologic reaction to MBP is widely accepted as evidence of myelinization in Schwann cells, the utilization of Leu-7 antigen as a marker for Schwann cells is relatively recent (14,15). Besides the similar semiquantitative A B expression, there was also a similar distribution pattern and labeling intensity of these antigens.…”
Section: Discussionmentioning
confidence: 97%
“…Although our findings confirm the presence of Schwann cells (S-100 protein. Col. IV), perineurial cells (EMA), axons (NF and NSE), and myelin (Leu-7, MBP), the mere qualitative presence or absence of these antigens has limited differential diagnostic value (7)(8)(9)(10)(11)(12)(13)(14)(15). Nevertheless, this immunohistochemical information, if correlated with the light microscopic features, provides a better understand- ing of the true nature of PEN.…”
Section: Discussionmentioning
confidence: 99%
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“…Desmoplastic melanomas express a pattern of early NCC markers including p75NGFR, N‐CAM, and peripherin, which could indicate a NCC progenitor like state, and sometimes are focally positive for tyrosinase and Mitf (Huttenbach et al., ). They do not express myelin or other markers of Schwann cell differentiation (Penneys et al., ). They are usually positive for S100 and Sox10, which label both melanocytes and Schwann cells (Mohamed et al., ; Palla et al., ).…”
Section: Connections Between Melanocytes and Schwann Cells In Human Dmentioning
confidence: 99%
“…Aso et al demonstrated expression of a Schwann cell‐associated protein (AHMY‐1), which reacted with P0 and P1 myelin proteins and myelin basic protein but not P2 myelin protein, in both type C nevus cells and nevic corpuscles (NC) 17 . Some authors have shown that type C nevus cells do not express myelin basic protein, a feature of terminally differentiated Schwann cells, by immunohistochemistry 22,23 . Reed et al showed that type C nevus cells and NC adopted an intermediate, “premyelinating/promyelinating” Schwann cell phenotype based on expression of low‐affinity nerve growth factor receptor (p75‐NGFR), neural cell adhesion molecule (N‐CAM/CD56), and growth‐associated phosphoprotein‐43 (GAP‐43) 21 .…”
mentioning
confidence: 99%