A survey of Clostridium spiroforme antimicrobial susceptibility in rabbit breeding

Agnoletti, Fabrizio; Ferro, Tiziana; Guolo, Angela; Marcon, Barbara; Cocchi, Monia; Drigo, Ilenia; Mazzolini, Elena; Bano, Luca

doi:10.1016/j.vetmic.2008.10.020

Cited by 16 publications

(10 citation statements)

References 9 publications

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“…A vaccine consisting of formalin-toxoided, C. spiroforme culture supernatant has been used experimentally but subsequent efforts are lacking in the literature [76]. The importance of vaccine development is further suggested, as antimicrobials used for treating rabbit colonies during a C. spiroforme outbreak have become less effective against this pathogen [77]. …”

Section: Pathogenic Bacilli and Binary Enterotoxins: Some Of The Bmentioning

confidence: 99%

Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being

Stiles

Pradhan

Fleming

et al. 2014

Toxins

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Some pathogenic spore-forming bacilli employ a binary protein mechanism for intoxicating the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their toxins include Clostridium botulinum (C2 toxin), Clostridium difficile (C. difficile toxin or CDT), Clostridium perfringens (ι-toxin and binary enterotoxin, or BEC), Clostridium spiroforme (C. spiroforme toxin or CST), as well as Bacillus cereus (vegetative insecticidal protein or VIP). These gut-acting proteins form an AB complex composed of ADP-ribosyl transferase (A) and cell-binding (B) components that intoxicate cells via receptor-mediated endocytosis and endosomal trafficking. Once inside the cytosol, the A components inhibit normal cell functions by mono-ADP-ribosylation of globular actin, which induces cytoskeletal disarray and death. Important aspects of each bacterium and binary enterotoxin will be highlighted in this review, with particular focus upon the disease process involving the biochemistry and modes of action for each toxin.

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Section: Pathogenic Bacilli and Binary Enterotoxins: Some Of The Bmentioning

confidence: 99%

Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being

Stiles

Pradhan

Fleming

et al. 2014

Toxins

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show abstract

“…Administration of antibiotics and change in diet are usually the treatment for C. spiroforme infections (Songer, 1996). The antibiotic susceptibility of C. spiroforme has been investigated (Agnoletti et al, 2009;Carman and Wilkins, 1991). C. spiroforme can have a wide range of resistance to antimicrobial classes used in rabbit therapy (Agnoletti et al, 2009).…”

Section: B Enterotoxemiamentioning

confidence: 99%

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

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“…For enterotoxemia, a dual approach of metronidazole (20 mg/kg every 12 hours) and cholestyramine (2 g/20 mL water every 24 hours by gavage) can be used to treat Clostridium infection and bind its toxin, although C spiroforme has widespread intrinsic and acquired antimicrobial resistance. 27,28 Chloramphenicol (50 mg/kg by mouth every 8 hours) can be used to attempt to suppress Clostridial overgrowth. 14,22 Preventing dysbiosis with a high-fiber diet and reducing stress is key to prevention.…”

mentioning

confidence: 99%

Gastrointestinal Disease in Guinea Pigs and Rabbits

DeCubellis

Graham

2013

Veterinary Clinics of North America: Exotic Animal Practice

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This article reviews diagnosis and management of gastrointestinal diseases in guinea pigs and rabbits. The review includes established causes of gastrointestinal disease in these species. The authors highlight syndromes that may be considered emerging or less-recognized causes of gastrointestinal stasis, including gastric dilation and volvulus in guinea pigs and lead toxicity, colonic entrapment, and liver torsion in rabbits. Practitioners should recommend initial diagnostics, including radiographs and blood work on guinea pigs and rabbits presenting with nonspecific signs of gastrointestinal stasis, to better determine possible cause and make the best treatment recommendations.

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A survey of Clostridium spiroforme antimicrobial susceptibility in rabbit breeding

Abstract: International audienc

Cited by 16 publications

References 9 publications

Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being

Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being

Biology and Diseases of Rabbits

Gastrointestinal Disease in Guinea Pigs and Rabbits

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