A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers

Wu, Yaoying; Norberg, Pamela K.; Reap, Elizabeth A.; Congdon, Kendra L.; Fries, Chelsea N.; Kelly, Sean H.; Sampson, John H.; Conticello, Vincent P.; Collier, Joel H.

doi:10.1021/acsbiomaterials.7b00561

Cited by 78 publications

(87 citation statements)

References 48 publications

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“… 36 , 37 More recently, hydrogels for controlled delivery of both cancer and infectious disease immunotherapies have shown promising results. 38 , 39 Numerous approaches have been utilized to create hydrogel systems for vaccine delivery, 40 − 43 though often focusing on innate immune activation for cancer therapy rather than sustained vaccine delivery to enhance humoral immune responses.…”

mentioning

confidence: 99%

Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity

et al. 2020

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Vaccines aim to elicit a robust, yet targeted, immune response. Failure of a vaccine to elicit such a response arises in part from inappropriate temporal control over antigen and adjuvant presentation to the immune system. In this work, we sought to exploit the immune system’s natural response to extended pathogen exposure during infection by designing an easily administered slow-delivery vaccine platform. We utilized an injectable and self-healing polymer–nanoparticle (PNP) hydrogel platform to prolong the codelivery of vaccine components to the immune system. We demonstrated that these hydrogels exhibit unique delivery characteristics, whereby physicochemically distinct compounds (such as antigen and adjuvant) could be codelivered over the course of weeks. When administered in mice, hydrogel-based sustained vaccine exposure enhanced the magnitude, duration, and quality of the humoral immune response compared to standard PBS bolus administration of the same model vaccine. We report that the creation of a local inflammatory niche within the hydrogel, coupled with sustained exposure of vaccine cargo, enhanced the magnitude and duration of germinal center responses in the lymph nodes. This strengthened germinal center response promoted greater antibody affinity maturation, resulting in a more than 1000-fold increase in antigen-specific antibody affinity in comparison to bolus immunization. In summary, this work introduces a simple and effective vaccine delivery platform that increases the potency and durability of subunit vaccines.

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confidence: 99%

Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity

et al. 2020

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“…[22] Subsequently, they used the fibril-forming peptide Q11 and the epitope-derived OVA 323-339 from ovalbumin or ESAT6 51-70 from Mycobacterium tuberculosis to form selfassembled peptide vaccine materials. [75] Compared to Q11 nanofibers, Coil29 nanofibers facilitated greater presentation of the model epitope SIINFEKL, demonstrating the ability of Coil29 nanofibers to stimulate immune responses. These nanofibers aroused immune responses without additional adjuvants.…”

Section: Peptide Nanocarriers For Immunotherapymentioning

confidence: 98%

Peptide‐Based Supramolecular Nanodrugs as a New Generation of Therapeutic Toolboxes against Cancer

Chang

Zou

Xing

et al. 2019

Advanced Therapeutics

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Peptides are an important class of biomaterials that are widely used in the biomedical field due to their biocompatibility, bioavailability, and structural diversity. They self-assemble into a variety of architectures by weak intermolecular interactions such as π-effects, van der Waals forces, ionic attraction, the hydrophobic effect, and hydrogen bonding, resulting in many advantages in cancer treatment. Self-assembling peptide nanostructures perform two functions: they act as nanocarriers to deliver drugs to tumor sites, and they regulate drug properties, for example, enhancing drug stability, improving the optical properties of photosensitizers, and increasing the immune response. This review focuses on peptide-based supramolecular nanodrugs or nanocarriers for different cancer treatment modalities, such as chemotherapy, phototherapy, and immunotherapy. In particular, peptides with special bioactive properties, such as tumor targeting, microenvironmental responsiveness, and antigenicity, will be highlighted for their utility in the effort to conquer cancer.

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“…3 (D)). Similarly, α-helical coiled-coil can also be formed into fibrils from α-helical peptide-like coil29 [65] . Such peptide sequences undergo assembly into fibrils with the antigenic epitope sticking outward from the fibril surface [6] .…”

Section: Protein/peptide-based Nanovaccinesmentioning

confidence: 99%