A Supramolecular Radical Dimer: High‐Efficiency NIR‐II Photothermal Conversion and Therapy

Tang, Bohan; Li, Wan‐Lu; Chang, Yincheng; Yuan, Bin; Wu, Yukun; Zhang, Ming‐Tian; Xu, Jiang‐Fei; Li, Jun; Zhang, Xi

doi:10.1002/ange.201910257

Cited by 51 publications

(18 citation statements)

References 70 publications

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“…25 Similar supramolecular polymerization was reported to construct a NIR-II chromophore via the tailor-made assembly of organic radicals for photothermal conversion and therapy. 26 In addition, porous coordination polymers with nanochannels and basic interaction sites allowed the highly accelerated, stereocontrolled, and monomerselective polymerization of substituted acetylenes. 27 Therefore, quantum-conned polymerizations can achieve low reaction activation energy of the reactions.…”

Section: Quantum-confined Molecule Superfluids and Qsf-like Molecule Reactionsmentioning

confidence: 99%

Quantum-confined superfluid reactions

et al. 2020

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Section: Quantum-confined Molecule Superfluids and Qsf-like Molecule Reactionsmentioning

confidence: 99%

Quantum-confined superfluid reactions

et al. 2020

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“…Due to their unique physicochemical properties, functional photothermal (PT) materials, especially organic materials capable of photothermal conversion from near-infrared light especially light within the second nearinfrared region (NIR-II, 1000-1700 nm), have attracted significant interest in the areas of energy, medical imaging, and photothermal therapy. [1][2][3][4][5][6] However, inherently low photothermal conversion efficiency (PCE) and photobleaching properties limit their development. [7][8][9][10][11] Fortunately, the photophysical process of organic molecules can be adjusted by changing the spatial arrangement of their microstructures.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-Bonding-Induced H-Aggregation of Charge-Transfer Complexes for Ultra-Efficient Second Near-Infrared Region Photothermal Conversion

Yin

Zhang

et al. 2022

CCS Chem

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Aggregation plays a critical role in modulating the photophysical process of organic molecules. However, rational control of the construction of a function-oriented stacking mode for efficient photothermal conversion in the second near-infrared region (NIR-II, 1000-1700 nm) remains a challenge. Herein, an H-aggregation of 3,3',5,5'-Tetramethylbenzidine (TMB)-TMB dication (TMB ++ ) complexes in linear agarose (H-TTC/LAG) with narrowed band gap (0.96 eV) is fabricated through intermolecular hydrogen bonding interactions between the amino groups of TTC and the peripheral hydroxyl groups of linear agarose. Charge transfer mechanism and Haggregation ensure the NIR-II absorption (over 1400 nm), and H-aggregation also promotes the non-radiation relaxation pathway and improves the thermal stability of TTC, which together gift the constructed H-TTC/LAG with ultra-efficient photothermal conversion that can quickly increase by 140 °C in 15 seconds under the NIR-II laser (1064 nm, 1.0 W cm -2 ) irradiation. Such unique H-TTC/LAG with good biocompatibility is used for photothermal therapy and demonstrates superior tumor growth inhibition efficiency. This is the H-aggregation of charge transfer complexes in a noncovalent system, which not only provides a new strategy to develop ultra-

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“…However, most studies have used photothermal agents with excitation in the NIR-I region (650-950 nm), [20][21][22][23][24][25] which may have low maximum permissible exposure (MPE; e.g., 0.33 W cm −2 at 808 nm) and insufficient tissue penetration depth. 26 Considering that NIR-II light (1000-1700 nm) has less tissue scattering, greater penetration depth, and higher MPE (e.g., 1 W/cm 2 at 1064 nm) than NIR-I light, 27,28 combined therapy that allows for excitation by NIR-II light to produce heat and tumor O 2 -independent free radicals may be preferable in treating deep-seated hypoxic tumors. 29 Yet a lack of efficient NIR-II excitable photothermal agents and free radical generators poses challenges to combinational tumor phototherapy under NIR-II light excitation.…”

Section: Introductionmentioning

confidence: 99%

Degradable Hybrid CuS Nanoparticles for Imaging-Guided Synergistic Cancer Therapy via Low-Power NIR-II Light Excitation

et al. 2021

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Near-infrared (NIR)-II light-excitable photonic agents capable of generating tumor hyperthermia and cytotoxic free radicals are promising for synergistic phototherapy of tumors. However, the lack of NIR-II excitable agents makes it challenging to achieve combinational tumor phototherapy. Here, the authors have reported on a tumor-targeting and degradable hybrid copper sulfide (CuS) nanoparticle (AIBA@CuS-FA) via loading a hydrophilic Azo initiator (AIBA) into an amphiphilic lipid-encapsulating CuS nanoparticle. AIBA@CuS-FA shows high photothermal conversion efficiency (PCE ≈ 47.5%) at 1064 nm, enabling heat production to trigger tumor hyperthermia and thermal decomposition of AIBA into cytotoxic free alkyl radicals upon irradiation with a 1064-nm laser under low-power density (0.5 W/cm 2 ). Moreover, alkyl radicals can drive degradation of AIBA@CuS-FA and embedded CuS nanodisks, releasing Cu 2+ ions that can catalyze a Fenton-like reaction for hydroxyl radical (•OH) production to promote tumor therapy. Findings demonstrate promise for combinational photothermal therapy (PTT), oxygen-independent alkyl radical therapy, and chemodynamic therapy (CDT) of tumors.

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A Supramolecular Radical Dimer: High‐Efficiency NIR‐II Photothermal Conversion and Therapy

Cited by 51 publications

References 70 publications

Quantum-confined superfluid reactions

Quantum-confined superfluid reactions

Hydrogen-Bonding-Induced H-Aggregation of Charge-Transfer Complexes for Ultra-Efficient Second Near-Infrared Region Photothermal Conversion

Degradable Hybrid CuS Nanoparticles for Imaging-Guided Synergistic Cancer Therapy via Low-Power NIR-II Light Excitation

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