A Suggested Revision of Normal Values for Hemoglobin, Hematocrit, and Erythrocyte Count in Healthy Adult Men

Combrinck

et al. 2002

Biochemical Journal

252

222

Section: Resultssupporting

confidence: 73%

Fate of haem iron in the malaria parasite Plasmodium falciparum

Combrinck

et al. 2002

Biochemical Journal

252

222

European J of Haematology

“…Greendyke, in 1962, proposed a more marked reduction in normal limits, based on data he obtained in US Army recruits (19). It is hard to evaluate his study because no information is given as to possible causes, such as blood donation, for lower values.…”

Section: Effect Of Other Variablesmentioning

confidence: 99%

Normal ranges for packed cell volume and hemoglobin concentration in adults: relevance to ‘apparent polycythemia’

Fairbanks

Tefferi

2000

Published data from Europe and North America indicate that for non-iron-deficient adult Caucasian males, the normal mean packed cell volume (PCV) is 0.46 and the 2.5-97.5 percentile interval is 04.0-0.53. Corresponding values for adult Caucasian females are: mean PCV 0.42; 2.5-97.5 percentile interval 0.36-0.48. It is not usually appropriate to undertake studies of polycythemia in adult Caucasian males with PCV < 0.55 (Hb Conc. < 180 g/L) or in adult Caucasian females with PCV < 0.50 (Hb Conc. < 16.5 g/L). Application of this principle will reduce the number of inappropriate and costly studies that would otherwise be performed in patients whose PCV values are only in the upper percentiles of the normal range, and will help to avoid misdiagnoses and therapeutic misadventures.

“…The present study is on a representative sample of a natural population unselected as to disease. Most published studies are of population samples that have been highly selected so as to give healthy clinical standards (Greendyke et al, 1962; Hawkins rt a/, 1954). Thc latter values all too often suffer because of arbitrary criteria or of lack in requisite numbcrs of subdivisions, such as by agc and sex.…”

Section: -45-55-65-75imentioning

confidence: 99%

Haematologic Profile of Natural Populations: Red Cell Parameters

Kelly

Munan

1977

Br J Haematol

Age-sex specific reference values and frequency distribution of erythrocyte parameters were derived from a representative sample of a natural population consisting of 1094 men and 1284 women between 10 and 96 years of age. Some differences have been found between previously reported reference values and those presented here, the importance of which lies not so much in their magnitude as in the fact that the latter are based upon a probability sample of a natural population unselected as to disease and are presented as percentile distributions by age and sex rather than as the more frequently used normal distribution. These results are intended for use as reference data both for clinical and for population estimates of haematological parameters.