2018
DOI: 10.1096/fj.201701350rr
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Abstract: Reduced fetal nutrition and rapid postnatal growth accelerates the aging phenotype in many organ systems; however, effects on the immune system are unclear. We addressed this by studying the thymus from a rat model of developmental programming. The recuperated group was generated by in utero protein restriction, followed by cross-fostering to control-fed mothers, and were then compared with controls. Fat infiltration and adipocyte size increased with age ( P < 0.001) and in recuperated thymi ( P < 0.05). Corte… Show more

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Cited by 11 publications
(9 citation statements)
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“…Since the structure and the function are closely related, the microstructure of different aged thymuses was explored by HE staining that showed a downtrend, except for a small increase at the 3 rd week, with significant alterations in ratio of the cortex to medulla. Similar changes in the aging thymus were also previously reported in rats [4143], African ostrich chicks [44, 45], and cynomolgus macaques [46, 47]. In addition, we also found an accumulation of adipose tissue while aging.…”
Section: Discussionsupporting
confidence: 90%
“…Since the structure and the function are closely related, the microstructure of different aged thymuses was explored by HE staining that showed a downtrend, except for a small increase at the 3 rd week, with significant alterations in ratio of the cortex to medulla. Similar changes in the aging thymus were also previously reported in rats [4143], African ostrich chicks [44, 45], and cynomolgus macaques [46, 47]. In addition, we also found an accumulation of adipose tissue while aging.…”
Section: Discussionsupporting
confidence: 90%
“…Tarry-Adkins et al reported comparable findings in a similar rat model exposed to mLPD. The decrease of thymic index and CMR was not observed in 3-month-old rat offspring but was present at 12 months of life (29) . Interestingly, Liu et al reported similar findings in an ovine model of IUGR (13) .…”
Section: Discussionmentioning
confidence: 80%
“…Phenotyping thymocyte subpopulations was considered relevant to provide markers of early alterations in the thymic cell selection process in a context of mLPD-induced IUGR. In a model combining fetal undernutrition and accelerated postnatal growth, Tarry-Adkins et al reported an accelerated replicative senescence in thymocytes of adult rat thymuses, although the proportions of thymocyte and lymphocyte subpopulations were not assessed (29) . We report original and prolonged alterations in the proportions of the CD4 and CD8 subpopulations of thymocytes and lymphocytes in adult male rats exposed to mLPD-induced IUGR.…”
Section: Discussionmentioning
confidence: 99%
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“…; Tarry‐Adkins et al . , ; Vaiserman, ). Most studies on ageing compare only two categorical life course time points.…”
Section: Introductionmentioning
confidence: 99%