A Sub-nL Chip Calorimeter and Its Application to the Measurement of the Photothermal Transduction Efficiency of Plasmonic Nanoparticles

Abstract

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Sub-nL thin-film differential scanning calorimetry chip for rapid thermal analysis of liquid samples

“…We have previously introduced a thin-film calorimeter chip featuring well-defined sub-nL twin microchannels for differential measurements of liquids and revealed the basic thermal characteristics of the chip based on theoretical and experimental treatments. 14,15 We have also showcased the differential measurement capability of the chip by the evaluation of the photothermal transduction efficiency of plasmonic nanoparticles. 15 Here, we further demonstrate its utility as a tfDSC chip (in DSC mode) for the measurement of liquids under a vacuum environment.…”

“…14,15 We have also showcased the differential measurement capability of the chip by the evaluation of the photothermal transduction efficiency of plasmonic nanoparticles. 15 Here, we further demonstrate its utility as a tfDSC chip (in DSC mode) for the measurement of liquids under a vacuum environment. Specifically, we present results from the phase and conformational transitions of liquid crystals and protein molecules.…”

Temperature non-uniformity detection on dPCR chips and temperature sensor calibration

“…This was also demonstrated earlier, when the readout of the RTD sensor calibrated traditionally differed from the actual fluid T by almost 10 °C. 22 We used relative to T M as the first calibration point ( Fig. 5A ).…”

“…However, it is impossible to determine T S within a single micro/nano partition using those sensors due to the size limitations. 22,23 The most popular non-contact temperature measurement method is based on an emitted infrared (IR) power determination. 10,19 This only determines the power of the IR radiation emitted from the surface, which for these chips is typically that of a glass covering the partitions inside the chip, meant to prevent water evaporation from the PCR master mix.…”

“… 27 This MCA-based non-contact temperature measurement technique was previously applied to determine the temperature uniformity inside of the microfluidic channel of a microcalorimeter, and the device was subsequently calibrated accordingly. 22,29 …”