A study to compare the effect of milk, licorice and tiger nut on stomach ulcer induced in rats

Abstract

Peptic ulcer is a disease affecting a large number of people, caused by various reasons including, NSAIDs and stress. Acute injury occurs more readily with aspirin. The extracts of milk,tigernut and licorice were evaluated for their activities against aspirin gastric ulcer induced in albino rats. Thirty male albino rats, with an average weight of 155-160g were used divided into five groups.6 rats each.All rats were fed basal diet and given free distilled water.Group (1) was left for the whole period of the study (29 days) as negative (-ve) control. Group (2) received 1 ml aspirin (acetyl salicylic acid) to induce gastric ulcer and left as positive control. The other 3 group received the same dose of aspirin; besides group 3 received milk, Group 4 received tiger nut, Group 5 received licorice as doses of 1 ml / rat each morning before breakfast, These 3 groups showed reduction of total area of the ulcer and accelerated healing. The result has shown an increase in final body weight gain of the rats, reduction of total area of the lesion and accelerated ulcer healing of rats treated with tiger nut,licorice and milk Also, reduced total cholesterol, LDL, triglycerides. while HDL was increased than the control

Phytotherapy of Gastric Ulcer (Literature Review)

“…In addition, Momeni A. et al [23] in 2014 noted that G Glabra extract is as effective as bismuth in preventing Helicobacter pylori and recommended effective treatment with licorice extract for patients who cannot take bismuth. Hajiagha Mohammadi and others [25] in 2016 G. glabra adding licorice to a triple clarithromycin-based regimen increases Helicobacter pylori eradication, especially in the presence of peptic ulcer disease. Nugroho A. E. in own studies [26] Glycyrrhiza glabra showed antiulcerogenic effects by increasing mucin secretion and prostaglandin E2 release and decreasing leukotrienes.…”