A Study on Electrolyte Imbalance in Asphyxiated Neonates

Rahman, Farhana; Siddique, Abu Bakar; Hassan, W. U.; Bari, Nasimul; Ahmed, Firoz

doi:10.3329/kyamcj.v7i2.33837

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…It was similar to the findings observed by Mishra et al, [29] Najaf Masood et al, [26] Rahman F et al [27] and Prodhan et al [30] in their studies. Gupta et al (2005) [31] in their study has shown that severity of renal function abnormality correlates well with degree of asphyxia.…”

Section: Discussionsupporting

confidence: 82%

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A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Das¹,

Murmu²,

Nayak³

2018

jemds

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BACKGROUND Perinatal asphyxia can lead to hypoxic ischaemic encephalopathy (HIE). The mortality due to hypoxic ischaemic encephalopathy is as high as 28.8% and morbidity is 30% of surviving newborn due to hypoxic ischaemic encephalopathy. Aims and Objectives-To study the plasma biochemical phenomena in neonates with hypoxic ischaemic encephalopathy in relation with severity of HIE. MATERIALS AND METHODSIt is a hospital-based prospective study done in tertiary care hospital in SCB Medical College Hospital and SVP PG Institute, Cuttack from November 2015 to October 2017. RESULTSThe babies with perinatal asphyxia develop hyponatraemia, hypocalcaemia, hyperkalaemia, high serum urea and creatinine, high serum ALT, AST, ALP, decrease in serum albumin and increase in Prothrombin time in proportion to the severity of asphyxia. CONCLUSIONA significant number of babies with birth asphyxia and deranged biochemical parameters either died or discharged with severe neurological sequelae. It can be concluded that deranged biochemical parameters are early indicators of poor outcome. Studies should be held on the effects of early correction of these metabolic derangements with their outcomes, so that it may invent a new horizon of treatment for birth asphyxia babies.

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Section: Discussionsupporting

confidence: 82%

“…Similar result was observed by Rahman F and Siddique MAB et al [27] in the year 2017. Study by G Joag et al (2017) [28] showed similar result of decreased mean value of serum sodium, serum calcium and serum glucose in asphyxiated newborns, which had positive correlation with the severity of birth asphyxia.…”

Section: Discussionsupporting

confidence: 80%

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Das¹,

Murmu²,

Nayak³

2018

jemds

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“…Our results are different from previous studies. In a study by Rehman F et al, the researchers found that hyponatremia is present in 30% of the asphyxiated babies while only 15% in total population (p value < 0.001) 15 . Shamaoon et al, discovered through a cross sectionals study that blood sodium was 137.71 1.69mg/dl (normal range) and concluded that mean serum electrolyte levels in neonates with perinatal birth asphyxia and mild hypoxic ischemic encephalopathy were within normal range.…”

Section: Discussionmentioning

confidence: 96%

“…After approval of study for local ethics committee, this Case control study was conducted in the Department of Pediatrics in collaboration with Department of Obstetrics & Gynecology, Aziz Bhatti Shaheed Teaching Hospital Gujrat from 1 st July 2019 to 30 th April 2021. Calculated sample size was 268 (134 cases and 134 controls) by taking prevalence of hyponatremia as 30.1% patients and 15% in control, 15 at 95% confidence interval and 80% power of study. For both cases and controls full term babies (>37 weeks) of either gender were included only as determined by hospital antenatal records.…”

Section: Methodsmentioning

confidence: 99%

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Association of Hypoxic Ischemic Encephalopathy With Hyponatremia In Term Infants Within First 24 Hours of Life

Afridi¹,

Afridi²,

Riaz³

et al. 2021

PJMHS

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Background: Electrolytes disturbances observed in hypoxic ischemic encephalopathy can further complicate the already asphyxiated babies Serum sodium is one of the most important electrolytes associated with neuronal activity, routinely serum sodium is added after 24 hour of life in maintenance fluid of neonates but we will monitor the changes in our suspected cases earlier so that early intervention should be done to reduce the perinatal mortality and its fatal outcomes. Aim: To determine the association of hyponatremia with hypoxic ischemic encephalopathy in term infants during first 24 hours of life. Methods: Case control study was carried out at Department of Pediatrics, Aziz Bhatti Shaheed Teaching Hospital Gujrat from12th Feb 2018 to 12th Feb 2019. 134 cases and 134 controls were included in the study. Full term babies (>37 weeks) of either gender was included for both cases and controls. Cases were hypoxic ischemic encephalopathy infants who has history of delayed cry at birth of >5 minutes, respiratory distress and moaning. Hyponatremia was labelled if serum sodium levels are below 130 mmol/lit. Matched controls i.e. healthy neonates from same setting were selected for the study. The serum sodium levels were compared between cases and controls. Results: Serum sodium was unequally distributed among cases & controls (Median±IQR 136±5, 139±8, P value using Mann Whitney U test= 0.01). Hyponatremia was also unequally distributed among cases & controls (3.4% vs 0.4%, P value using Fischer exact test = 0.01). Logistic regression analysis using STEP wise analysis proved that the association found regarding hyponatremia/ serum sodium with hypoxic ischemic encephalopathy is not significant after adjusting for weight and gender of the infant. The distribution of birth weight and gender among cases and controls was similar (P value > 0.05). Conclusion: It is concluded that hyponatremia is not associated with hypoxic ischemic encephalopathy in term infants during first 24 hours of life. Keywords: Hypoxic ischemic encephalopathy, Hyponatremia, Serum sodium, Perinatal asphyxia

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Study of Serum Electrolytes and Calcium Changes in Children with Severe Pneumonia and it’s Outcome

et al. 2022

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Background: Electrolyte imbalance is one of the serious complications in hospitalized children with severe pneumonia. Monitoring of changes in electrolytes is very essential to prevent the complications leading to increased morbidity and mortality. Aims and objectives: To study serum electrolytes and calcium disturbances in patients with severe pneumonia. To identify relation of serum electrolytes with outcome of severe pneumonia. Material and Methods: After taking approval of ethics committee of our institute, we studied a total of hundred cases over a span of 24 months- August 2018 to December 2020. Study is carried out among cases of severe pneumonia and community acquired pneumonia (CAP) in age group of 2 months to 5 years admitted in pediatrics department of tertiary care centre in Maharashtra. Laboratory investigations of serum sodium, potassium, chloride and calcium levels were noted at admission and 24 hours after hospitalization. Results: This is observational cross study carried out in 100 children of severe pneumonia admitted in paediatric intensive care unit at Dr. Vasantrao Pawar Medical College, Nashik to observe and study electrolyte changes in them. Most children were in age group of 2 months to 12 months (i.e., 72%) followed by 28% in age group of 13 months to 60 months. At admission most common abnormality was hypocalcemia 49% followed by hyponatremia 27%, hyperchloremia 7%, hyperkalemia 6%, hypernatremia 6%, hypokalemia 4%, hypochloremia 1%. After 24 hours of stabilization hyponatremia was most common 40%, followed by hapocalcemia 43%, hypokalemia 9%, hypernatremia 8%, hyperkalemia 4%, hyperchloremia 4%. Conclusion: Mortality was significantly higher in cases with chloride level abnormality than with normal chloride level. Cases with disturbances in electrolytes showed higher mortality than those without electrolyte disturbances. Hyponatremia and hypokalaemia were associated with adverse outcomes in pneumonia cases. Electrolyte disturbances are commonly seen in pneumonia cases, so we should monitor them properly while treating them to avoid complications. Hyponatremia in pneumonia occurs due to Syndrome of Inappropriate Anti Diuretic Hormone secretion (SIADH). Hyponatremia at admission significantly affect outcome in terms of prolonged duration of hospitalization and two fold increase in mortality.

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A Study on Electrolyte Imbalance in Asphyxiated Neonates

Abstract: In

Cited by 6 publications

References 5 publications

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Association of Hypoxic Ischemic Encephalopathy With Hyponatremia In Term Infants Within First 24 Hours of Life

Study of Serum Electrolytes and Calcium Changes in Children with Severe Pneumonia and it’s Outcome

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