A study of two protocols combining aglepristone and cloprostenol to treat open cervix pyometra in the bitch

Gobello, Cristina; Castex, Gervasio; Klima, Liliana; Rodríguez, Raúl Ricardo; Corrada, Yanina Alejandra

doi:10.1016/s0093-691x(03)00094-3

Cited by 45 publications

(36 citation statements)

References 3 publications

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“…Although successful management is increasing with advances in therapeutic approaches [26], recurrence of pyometra after medical treatment is likely [10,[34][35][36][37]. During surgery, extreme care must be taken not to rupture the friable wall of the pus-filled uterine horns and not to expel the pus through the uterine tube.…”

Section: Discussionmentioning

confidence: 99%

Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls

et al. 2014

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“…To maintain fertility or if surgery or anesthesia is to be avoided, several medical treatment alternatives are available. Examples of drugs that can be used for medical treatment of pyometra include progesterone-receptor antagonists (aglepristone and mifepristone), prostaglandins (dinoprost and cloprostenol), dopamine agonists (cabergoline), or different combinations of these drugs [11][12][13][14][15]. Few studies have evaluated the long-term outcome after medical treatment, and for aglepristone, the time of follow-up evaluation varies from after the following estrus [16,17], after 1 year [18], after 2 years [19], or up to 54 months after treatment for a few bitches [13].…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of bitches with pyometra, medically treated with aglepristone

2014

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Pyometra is a common and life-threatening disease of intact bitches caused by hormonal influence of the uterus in combination with bacterial infection. The treatment of choice is ovariohysterectomy, but several purely medical options are available. Common drugs used for medical treatment in combination with antimicrobials are progesterone receptor blockers, prostaglandins, and dopamine agonists. The aim of this study was to evaluate long-term recovery and fertility after treatment with the progesterone receptor blocker aglepristone in bitches with pyometra. Data from 28 bitches with pyometra, admitted to the University Animal Hospital, Swedish University of Agricultural Sciences, during a 9-year period, were studied retrospectively and followed up by telephone interviews with the owners. The bitches had been treated with aglepristone at a dose of 10 mg/kg on a median of four occasions. All bitches had also been treated with antimicrobial drugs for a mean duration of 23 days, the most frequently used being enrofloxacin. Escherichia coli were the most commonly isolated bacteria from cranial vagina. The outcome was assessed for up to 6 years after treatment. The success rate, determined as restored clinically healthy status, was 75% (21/28 bitches), and the recurrence rate of disease was 48% (10/21 bitches). The mean time until recurrence was 10.5 months after the end of treatment. After treatment, 69% (9/13) of the mated bitches produced puppies. Of the seven bitches that did not have a successful treatment, six were ovariohysterectomized and one was euthanized. In conclusion, medical treatment with aglepristone in combination with antimicrobial therapy was successful in 75% of the bitches studied and the recurrence rate was 48%.

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“…1992; Fieni et al. 1996, 2001; Hubler and Arnold 2000; Gobello et al. 2003; Georgiev and Wehrend 2005; Wehrend and Georgiev 2006), conservative treatment of pyometra (Blendinger et al.…”

Section: Introductionmentioning

confidence: 99%

Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating

Georgiev

Bostedt

Goericke-Pesch

et al. 2009

Reproduction in Domestic Animals

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The aim of this study was to test for the efficacy and safety of the use of aglepristone for pregnancy termination on day 45 in cats. Six healthy cats were treated with 10 mg/kg aglepristone sc on day 45 and 46 after mating; six other cats served as untreated controls. The effect of treatment was monitored by general examination, vaginal cytology, ultrasonography and blood sampling for haematology and progesterone determination. Besides, interoestrus interval and next pregnancy including litter size were recorded. The efficacy of treatment was approximately 67% (4/6) with abortion occurring 4-7 days after the first injection and a sanguineous discharge and erythrocytes in vaginal smears for at least 6 days afterwards. The two treated cats that did not abort gave birth to two kittens on day 67 and had a stillbirth of a single kitten on day 71, respectively. As expected enlargement of the mammary glands and lactation were observed in all treated cats. No other treatment-induced side effects were observed. Progesterone levels at abortion were high (30-140 nmol/l), but were decreased on day 55. Aglepristone treatment did not affect fertility in following cycles. Finally, it can be concluded that late-term pregnancy termination with aglepristone is possible but due to a success rate of 67% an ultrasonographical examination 7 days after treatment is an inherent necessity to control the effect of treatment.

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A study of two protocols combining aglepristone and cloprostenol to treat open cervix pyometra in the bitch

Cited by 45 publications

References 3 publications

Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls

Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls

A retrospective study of bitches with pyometra, medically treated with aglepristone

Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating

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