A Study of Three Doses of Ici 35 868 for Induction and Maintenance of Anaesthesia

Major, E.; Verniquet, Andrew; Waddell, Tamara K.; Savage, Tessa; Höffler, D; Aveling, W.

doi:10.1093/bja/53.3.267

Cited by 60 publications

(19 citation statements)

References 4 publications

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“…did not affect the frequency of pain on injection, so it is probable that the reduced incidence in this study (12%) is related more to the site of injection than to the premedication with fentanyl. The fact that two patients out of 26 (8%) required a higher dose of disoprofol is in keeping with the findings of others (Rogers et al, 1980;Briggs et al, 1981;Major et al, 1981), who found that 2mgkg" 1 induced anaesthesia successfully in 90-100% of patients without unacceptable arterial hypotension or respiratory depression. They found l.Smgkg" 1 was unreliable and produced anaesthesia in only 25-70% of patients.…”

Section: Discussionsupporting

confidence: 88%

Comparision of Ici 35868, Etomidate and Methohexitone for Day-Case Anaesthesia

Wells¹

1985

British Journal of Anaesthesia

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ICI 35868 is a substituted phenol (2-6, diisopropyl phenol) which has been shown to have anaesthetic properties. It is rapidly acting (7J approximately 55 min), and is completely metabolized, mainly by conjugation with glucuronic acid. There is minimal cumulation, more than 90 % of the dose being recovered in the urine (as metabolites) within 48 h.This study was designed to compare the efficacy and side-effects of di-isopropyl phenol, etomidate and methohexitone, when used for day-case anaesthesia. PATIENTS AND METHODSSeventy-one female patients in good general health (ASA class I), aged between 18 and 65 yr and scheduled for minor gynaecological procedures (dilatation and curettage or termination of pregnancy) were included in this open study. Written informed consent was obtained from each patient. Those with a history of allergy, atopy, previous known exposure to Cremophor and those taking drugs not specified in the trial, were excluded. Patients were allocated randomly to three groups to receive di-isopropyl phenol, etomidate or methohexitone. The number of patients undergoing dilatation and curettage or termination of pregnancy was balanced in each group. Anaesthetic techniqueAll patients received fentanyl 0.001 mg/kg body weight 2 min before the induction of anaesthesia.ICI 35868 was presented as a 1 % solution of di-isopropyl phenol in 16% Cremophor EL with water to 100% (disoprofol), and the other drugs were used in the commercially available preparations (etomidate, Janssen Pharmaceuticals; methohexitone, Eli Lilly & Co. Limited). SUMMARYInduction doses of disoprofol l.Smgkg" 1 (« = 26), etomidate 0.2 mgkg~l(« = 22) or methohexitone 1.5 mg kg~l {n = 23) were administered over 20 s (forearm or antecubital vein), and anaesthesia was maintained with 70% nitrous oxide in oxygen via a face mask, plus further increments of the appropriate induction agent. Incremental doses were 10-20% of the induction dose. At the end of surgery, 100% oxygen was administered for 2 min. Assessments of patientsThe following observations were made by one of two observers (the majority being made by the author): Induction time from the start of injection to the loss of eyelash reflex was measured in seconds; pain on injection was rated as present when reported spontaneously or in response to the question " Is your arm comfortable?" Respiratory abnormalities such as hiccup, sneeze, bronchospasm or apnoea of more than 30 s duration were noted. Heart rate, systolic and diastolic arterial pressures were recorded (Dinamap) at 1-min intervals. Recordings were started 2 min before the induction Downloaded from https://academic.oup.

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Section: Discussionsupporting

confidence: 88%

Comparision of Ici 35868, Etomidate and Methohexitone for Day-Case Anaesthesia

Wells¹

1985

British Journal of Anaesthesia

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“…Adequate facilities for artincial ventilation must be available, because although in the event of overdosage with an intravenous anaesthetic intermittent positive pressure ventilation will have no effect on the elimination of the drug administered, oxygenation and carbon dioxide removal must be ensured. Disoprofol (2,6 di-isopropylphenol presently solubilised in 16% cremophor EL) appeared a potentially suitable agent for total intravenous anaesthesia trials in the horse, due to its rapid onset of action, duration of effect due to rapid metabolism in man and other species, and apparent lack of cumulation (Adam et al, 1980;G~n, 1980;Ruther et al, 1980;Briggs et al, 1981;Major et al, 1981, Verniquet et al, 205. 1981Heneghan et al, 1982).…”

mentioning

confidence: 99%

Disoprofol Anaesthesia in Horses – A Preliminary Report

Nolan

1982

Proceedings of the Association of Veterinary Anaesthetists

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“…A further potential advantage of the reduced doses of propofol required for induction of anaesthesia and insertion of the laryngeal mask may be improved cardiovascular stability and reduced respiratory depression. It is known that the extent of the blood pressure reduction seen with propofol is dose dependant [26,27]. This present study did not aim to examine this aspect.…”

Section: Discussionmentioning

confidence: 94%