A study of the killer cell immunoglobulin‐like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris

Abstract

Psoriasis is a chronic inflammatory skin disease whose pathogenesis and genetic background remain unclear. Considering that previous studies have suggested an association of psoriasis vulgaris (PV) and killer cell immunoglobulin-like receptors (KIRs), we typed 15 KIR genes and human leukocyte antigen (HLA)-Cw in 79 Brazilian Caucasoid patients with PV and 110 healthy controls by polymerase chain reaction (PCR) using sequence-specific oligonucleotides and sequence-specific primers. We did not observe a relevant increase in the frequency of the activating KIR2DS1 gene in the PV group [KIR2DS1, 46 of 79 cases (58.2%) vs 40 of 110 controls (36.4%)]. However, an association of KIR2DS1 with Cw*0602+ in 26.5% of PV patients was observed, while it was present in only 5.4% of controls. These results suggest that activating KIR2DS1 gene may not confer susceptibility to PV, and an association of KIR2DS1 gene with the HLA-Cw*0602+ was observed in these patients.

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

“…However, in contrast to HLA-Cw*06 , association of KIR2DS1 with psoriasis seemed stronger in higher age at onset values, although the age effect was not significant because of small numbers of patients with late disease onset (Luszczek et al, 2004). Very similar association of KIR2DS1 (and KIR2DL5 in addition, which was not analyzed in our study) was simultaneously published for Japanese population, genetically distant from Poles (Suzuki et al, 2004), and confirmed later in Swedish and Brazilian Caucasians with psoriasis vulgaris (Holm et al, 2005; Jobim et al, 2008), but not in Swedes with guttate psoriasis (Holm et al, 2005) or in Taiwanese Chinese with plaque psoriasis (Chang et al, 2006; see Table 2). Interestingly, KIR2DS1 gene appeared associated also with psoriatic arthritis (Martin et al, 2002b; Holm et al, 2005; Williams et al, 2005; Table 2).…”

Killer cell immunoglobulin-like receptor (KIR) genes in systemic sclerosis

“…The results of HLA-C typing were separated into two groups: HLA-C group 1 (C1), consisting of HLA-C 01, 03, 07 (01-06), 08, 12 (02, 03, 06), 14, 16 (01, 03, 04) and HLA-C group 2 (C2) consisting of HLA-C 02, 04, 05, 06, 0707, 12 (04, 05), 15, 1602, 17, 18 [19]. HLA-C group 1 (C1) mol-ecules bind to KIR2DS2, KIR2DL2 and KIR2DL3, while group 2 (C2) molecules bind to KIR2DS1 and KIR2DL1 [20].…”

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen–C genotypes in South Brazilian with type 1 diabetes

“…KIR genotypes and HLA ligand patterns have been recognized for diseases and disease conditions such as hepatitis C [18], psoriasis vulgaris [19,20], psoriatic arthritis [21,22], rheumatoid arthritis [23], celiac disease [24], ulcerative colitis [25,26], Crohn's disease [27], human immunodeficiency virus [28], recurrent miscarriage [29], and leprosy [30], as well as in T1D [31][32][33][34][35][36][37][38][39].…”