A Study of the Immunologic Aspects of Chronic Berylliosis

Deodhar, Sharad D.; Barna, Barbara P.; Ordstrand, Howard S. Van

doi:10.1378/chest.63.3.309

Cited by 80 publications

(30 citation statements)

References 5 publications

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“…The peripheral blood BeLPT, which measures lymphocyte proliferation in response to beryllium salts (beryllium sulfate, beryllium fluoride) in vitro, is elevated in individuals with beryllium disease and in those sensitized to beryllium (1)(2)(3)5,6). The use of bronchoalveolar lavage (BAL) Posterior/anterior chest X-rays were evaluated according to the International Labor Office (ILO) classification system for radiographs of pneumoconioses by boardcertified radiologists who were certified Breaders (7).…”

Section: The Beryllium Lymphocyte Proliferation Testmentioning

confidence: 99%

Rocky Flats Beryllium Health Surveillance.

Stange¹,

Furman²,

Hilmas³

1996

Environ Health Perspect

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was designed to provide medical surveillance for current and former employees exposed to beryllium. The BHSP identifies individuals who have developed beryllium sensitivity using the beryllium lymphocyte proliferation test (BeLPT). A detailed medical evaluation to determine the prevalence of chronic beryllium disease (CBD) is offered to individuals identified as beryllium sensitized or to those who have chest X-ray changes suggestive of CBD. The BHSP has identified 27 cases of CBD and another 74 cases of beryllium sensitization out of 4268 individuals tested. The distribution of BeLPT values for normal, sensitized, and CBD-identified individuals is described. Based on the information collected during the first 3 1/3 years of the BHSP, the BeLPT is the most effective means for the early identification of beryllium-sensitized individuals and to identify individuals who may have CBD. The need for BeLPT retesting is demonstrated through the identification of beryllium sensitization in individuals who previously tested normal. Posterior/anterior chest X-rays were not effective in the identification of CBD. -Environ Health Perspect 104(Suppl 5): 981-986 (1996)

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Section: The Beryllium Lymphocyte Proliferation Testmentioning

confidence: 99%

Rocky Flats Beryllium Health Surveillance.

Stange¹,

Furman²,

Hilmas³

1996

Environ Health Perspect

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show abstract

“…In 1970, Hanifin and associates demonstrated beryllium-induced release of migration inhibition factor in peripheral blood cells of patients with CBD (19). Soon after, Deodhar and coworkers reported a correlation between the clinical status of CBD and in vitro responses to beryllium in an LPT (10). This test utilized peripheral blood mononuclear cells and was initially called a lymphocyte transformation test because abnormal (elevated) responses to beryllium sulfate challenge in vitro were determined by morphological quantitation of lymphoblasts (10).…”

Section: Beryllium Sensitivity Testingmentioning

confidence: 99%

“…Soon after, Deodhar and coworkers reported a correlation between the clinical status of CBD and in vitro responses to beryllium in an LPT (10). This test utilized peripheral blood mononuclear cells and was initially called a lymphocyte transformation test because abnormal (elevated) responses to beryllium sulfate challenge in vitro were determined by morphological quantitation of lymphoblasts (10). The test was modified to utilize tritiated thymidine uptake as an indicator of response (50).…”

Section: Beryllium Sensitivity Testingmentioning

confidence: 99%

Clinical Application of Beryllium Lymphocyte Proliferation Testing

Barna

Culver²,

Yen‐Lieberman

et al. 2003

Clin Vaccine Immunol

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“…Its use as a pure metal in aerospace and nuclear reactors, as an oxide, and as an alloy has led to the development among industrial workers of a granulomatous disease due to a delayed-type hypersensitivity to beryllium (31). Chronic beryllium disease (CBD), as it is known, is characterized by activation and maturation of macrophages (M) along with recruitment and expansion of CD4 ϩ T lymphocytes (7,24,42). Patients with CBD, who have been exposed to and sensitized against beryllium salts in the workplace, exhibit specific peripheral blood and alveolar lymphocyte proliferative responses to Be (31,33).…”

mentioning

confidence: 99%