A Study of Risk Factors for Ovarian Metastases in Stage IB–IIIB Cervical Carcinoma and Analysis of Ovarian Function after a Transposition

Yamamoto, Ritsu; Okamoto, Kazuhira; Todo, Yukiharu; Kaneuchi, Masanori; Negishi, H.; Sakuragi, Noriaki; Fujimoto, Seiichiro

doi:10.1006/gyno.2001.6277

Cited by 93 publications

(95 citation statements)

References 13 publications

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“…In cases of early stage cervical cancer with squamous cell types, less than 1% involve tumor spread to the ovaries (Morice et al, 2001;Yamamoto et al, 2001;Shimada et al, 2006). For example, Morice et al (2001) evaluated 107 cases of SCCC involving OT, and only two cases developed metastases in the ovaries (Morice et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the period for this recurrence was three years in each case. In cases of cervical adenocarcinoma, the reported rates of ovarian metastases vary widely from 1.7-28.6% (Tabata et al, 1987;Nakanishi et al, 2001;Yamamoto et al, 2001;Shimada et al, 2006). Moreover, a non-squamous histological type has been identified as an independent risk factor for ovarian metastases in cervical cancer (Yamamoto et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…While Tabata et al previously reported that metastatic spread to the ovary is associated with more advanced tumors and has been associated with a frequency as high as 17.4% in autopsy cases of epidermoid carcinoma (Tabata et al, 1987), generally, ovarian metastasis is identified in less than 1% of all cases involving squamous cell carcinoma (Morice et al, 2001;Yamamoto et al, 2001). Typically, OT is performed for patients who are below 40 years, have a small invasive cervical carcinoma (<3 cm, or stage Ib or II) that can be treated with a combination of radiotherapy and surgery, and have an absence of other risk factors for ovarian metastases (Yamamoto et al, 2001). The risk factors for ovarian metastases and criteria for transposition of the ovaries include uterine corpus invasion, a non-squamous histological type, and lymphovascular space invasion (LVSI) (Morice et al, 2001;Yamamoto et al, 2001).…”

Section: Introductionmentioning

confidence: 98%

“…Typically, OT is performed for patients who are below 40 years, have a small invasive cervical carcinoma (<3 cm, or stage Ib or II) that can be treated with a combination of radiotherapy and surgery, and have an absence of other risk factors for ovarian metastases (Yamamoto et al, 2001). The risk factors for ovarian metastases and criteria for transposition of the ovaries include uterine corpus invasion, a non-squamous histological type, and lymphovascular space invasion (LVSI) (Morice et al, 2001;Yamamoto et al, 2001). Nonetheless, there is ongoing debate about the effectiveness of ovarian transposition with respect to protecting gonadal functions and metastasis to the transposed ovaries (Dursun et al, 2009) and there are very few studies that have evaluated the prognosis of OT in cervical cancer (Windbichler et al, 1999) Therefore, the impact of OT on survival rates for patients with stage Ib squamous cell cervical cancer (SCCC) was investigated in this study.…”

Section: Introductionmentioning

confidence: 99%

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Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Turan

Keskin²,

Dündar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: To investigate the impact of ovarian transposition (OT) on survival rates of the patients with stage Ib squamous cell cervical cancer. Materials and Methods: Ninety-two subjects who underwent a radical hysterectomy including oophorectomy were evaluated. For nineteen (20.7%) , OT was performed. Patients were divided into two groups, OT versus oophorectomy alone. The primary end-point of this study was to investigate the impact of OT on tumor recurrence rate and time, 5-year disease-free survival (DFS) and overall survival (OS) . These comparisons were performed for subgroups including patients who received radiotherapy versus who did not. Statistical analyses were conducted using the Chi-square test, T-test and Mann-Whitney test. OS was examined using the Kaplan-Meier method. P≤0.05 was considered to be statistically significant. Results: The median follow-up period was 89 months for OT and 81 months for the oophorectomy group (p>0.05). Both groups experienced similar recurrence rates (31.6% vs. 26.4%, p=0.181). The median duration from surgery to recurrence, and surgery to death were also similar between the groups (p>0.05). The 5-year DFS and OS rates were both 68.4% for the OT group, and 73.6% and 77.8% for the oophorectomy group (p=0.457 and p=0.307, respectively). While the 5-year DFS rate was not statistically significant between the OT and oophorectomy groups who did not receive radiotherapy (p=0.148), the 5-year OS rate was significantly higher in the oophorectomy group (95.4% vs 66.7%, respectively) without radiotherapy (p=0.05). The 5-year DFS and OS rates were statistically similar between the groups who received adjuvant radiotherapy (p>0.05). Conclusions: Ovarian transposition has not significantly negative effect on the survival rates when adjuvant radiotherapy will be applied, while 5-year OS may be less in OT group if radiotherapy is not mandatory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Turan

Keskin²,

Dündar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…O temor de metástases ovarianas em lesões escamosas (<1%) ou adenocarcinoma cervical uterino (1,4%) 8,9 , não constitui indicação para remoção de ovários de aparência macroscopicamente normal durante a cirurgia em pacientes jovens submetidas a histerectomia radical, desde que estas apresentem ciclos menstruais regulares e ausência de sinais e/ou sintomas compatíveis com privação estrogênica 2 . Nos relatos de comprometimento ovariano, a extensão endometrial ou para o corpo uterino foi encontrada, sugerindo a possibilidade de extensão direta da neoplasia para o ovário 8 .…”

Section: Discussionunclassified

Preservação dos ovários em cirurgia radical para câncer do colo uterino

Vieira¹,

Silva²,

Vale³

et al. 2002

Rev. Bras. Ginecol. Obstet.

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mL). Das nove pacientes com níveis elevados de FSH, cinco (55,6%) haviam sido submetidas a radioterapia pós-operatória (p<0,0001). Não houve associação entre a idade das pacientes e os níveis de FSH (p=0,33). Cistos ovarianos funcionais ocorreram em quatro pacientes (7,7%Introdução O câncer do colo uterino é sério problema de saúde pública na América Latina, sendo a primeira causa de morte na população feminina em idade reprodutiva 1 . O tratamento de escolha para casos de câncer do colo uterino invasivo em estágios iniciais é a histerectomia radical com salpingooforectomia bilateral. Entretanto, a preservação dos ovários em pacientes jovens submetidas à cirurgia radical para câncer do colo uterino apresenta manutenção da função ovariana entre 70 e 83% dos casos, bem como baixa morbidade associada 2-4 . Tendo em vista que parcela significativa dos casos de câncer do colo uterino ocorre em mulheres jovens, a preservação dos ovários deve sempre ser oferecida à paciente, visto que a ooforectomia bilateral implicará sintomatologia vasomotora e gênito-urinária associada ao climatério e complicações mórbidas como a osteoporose. Além disso, a reposição estrogênica nas pacientes submetidas a ooforectomia implica comprometimento importante do orçamento familiar, devido ao baixo nível socioeconômico da maioria das pacientes com câncer do colo uterino 5,6 .Este estudo tem como objetivo a avaliação da função ovariana em pacientes com câncer do colo uterino, que se submeteram a histerectomia radical com manutenção dos ovários.

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Squamous Cell Carcinoma of the Ovary

Spencer

Rice

2014

Uncommon Gynecologic Cancers

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A Study of Risk Factors for Ovarian Metastases in Stage IB–IIIB Cervical Carcinoma and Analysis of Ovarian Function after a Transposition

Cited by 93 publications

References 13 publications

Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Preservação dos ovários em cirurgia radical para câncer do colo uterino

Squamous Cell Carcinoma of the Ovary

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