A Study of Plant Coumarins. 18. Conjugates of Coumarins with Lupane Triterpenoids and 1,2,3-Triazoles: Synthesis and Anti-Inflammatory Activity

Application of triazoles in the structural modification of natural products

“…Coumarin-triazole derivatives not only possess anticancer activity 58 , 68 , 70 , 90–93 , but also they exhibit anti-inflammatory activity 115 . Lipeeva et al.…”

“…Lipeeva et al. 115 synthesised conjugates of coumarin possessing lupan triterpenoids and 1,2,3-triazole and tested their anti-inflammatory activity. Among them, compound 48 ( Figure 10 ), a conjugate of lupine triterpenoid with furocoumarin oreoselone, possessed marked anti-inflammatory activity.…”

“…Coumarin-triazole derivatives not only possess anticancer activity 58 , 68 , 70 , 90–93 , anti-inflammatory activity 115 , and antibacterial activity 128 , 129 , but also they exhibit antifungal activity 133 . A series of new coumarin-, quinolinone-, and benzyl-linked 1,2,3-triazole derivatives were synthesised and screened for their antibacterial and antifungal activities by Savanur and et al.…”

“…Coumarin-triazole derivatives not only possess anticancer activity 58 , 68 , 70 , 90–93 , anti-inflammatory activity 115 , antibacterial activity 128 , 129 , antifungal activity 133 , antimalarial activity 140 , antioxidant activity 154 , and anti-Alzheimer’s activity 156–164 , but also they exhibit pancrelipase inhibitory activity 167 . Kahveci et al.…”

Click Chemistry in Natural Product Modification

“…Mechanistic studies indicated that E14 could block cell cycle at the G1 phase, induce mild cell apoptosis via both intrinsic and extrinsic pathways in HL-60 cells. Lipeeva et al reported that C28 betulonic acid-furocoumarin oreoselone hybrid E15 could significantly reduce histamine-induced paw edema (edema index: 24.5%) to a level that was comparable to the nonsteroidal anti-inflammatory drug indomethacin (edema index: 22.4%) ( Lipeeva et al, 2020 ). Shi et al reported that C30 betulinic acid-triazole derivative E13 (IC 50 = 1.3 μ M) could exert more potent antiproliferative than betulinic acid (IC 50 = 11.5 μ M) in HL-60 cells (leukaemia) ( Shi et al, 2015 ).…”