A study of human neutrophil antigen genotype frequencies in Hong Kong

Tam, Kar-Fai; Tang, Ivan; Ho, Jenny; Yeung, William S.B.; Lee, C. K.; Ip, Patrick; Kwok, Janette

doi:10.1111/tme.12494

Cited by 7 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the current analysis showed SLC44A2∗1 as the dominant allele with a 0.63 frequency. Interestingly, this frequency is significantly different from other reports in the other populations [ 7 , 9 , 11 ]. The results of HNA-5 typing in 190 Azerbaijani blood donors showed 0.51 and 0.49 frequencies for ITGAL∗1 and ITGAL∗2, respectively [ 16 ].…”

Section: Discussioncontrasting

confidence: 99%

“…Our analysis showed a similar frequencies for HNA-1, HNA-4, and HNA-5 alleles with the previous reports from German and British populations [ 22 ]. However, these frequencies were significantly different from the Chinese populations [ 9 , 21 ]. In contrast to Japanese and Chinese reports and similar to Caucasian reports, in the current cohort, FCGR3B∗02 was the most frequently detected HNA-1 allele [ 7 , 9 , 11 , 13 , 15 , 21 – 23 ].…”

Section: Discussionmentioning

confidence: 60%

“…However, these frequencies were significantly different from the Chinese populations [ 9 , 21 ]. In contrast to Japanese and Chinese reports and similar to Caucasian reports, in the current cohort, FCGR3B∗02 was the most frequently detected HNA-1 allele [ 7 , 9 , 11 , 13 , 15 , 21 – 23 ].…”

Section: Discussionmentioning

confidence: 60%

“…HNA allele frequencies have been extensively studied among different populations such as Japanese [ 7 ], Chinese [ 8 ], Hong Kong [ 9 ], Thai [ 10 ], Turkish, German [ 11 ], and Africa American [ 12 ], African Blacks [ 13 ], northern Germany and Uganda [ 14 ], and Danish and Zambian [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Esmaeili

Bayat

Alirezaee

et al. 2022

Journal of Immunology Research

View full text Add to dashboard Cite

Objective. Human neutrophil antigens (HNAs) can be targeted by HNA-allo antibodies and cause a variety of clinical conditions such as transfusion-related acute lung injury (TRALI) and neonatal alloimmune neutropenia (NAIN). The current study is aimed at identifying the genotype and allele frequencies of HNAs in Iranian blood donors. Methods. A total of 150 blood samples were obtained from healthy blood donors. HNA-1, HNA-3, HNA-4, and HNA-5 were genotyped, using the polymerase chain reaction sequence-specific primer (PCR-SSP) technique. The expression of the HNA-2 antigen on the neutrophil surface was evaluated by flow cytometry. Results. The allele frequencies of FCGR3B ∗ 1 (encoding HNA-1a), FCGR3B ∗ 2 (encoding HNA-1b), and FCGR3B ∗ 3 (encoding HNA-1c) were 0.34, 0.63, and 0.03, respectively. For HNA-3, the allele frequencies for SLC44A2 ∗ 1 (encoding HNA-3a) and SLC44A2 ∗ 2 (encoding HNA-3b) were 0.63 and 0.37, respectively. The frequencies of ITGAM ∗ 1 (encoding HNA-4a) and ITGAM ∗ 2 (encoding HNA-4b) alleles were 0.85 and 0.15, respectively. Furthermore, the frequencies of ITGAL ∗ 1 (encoding HNA-5a) and ITGAL ∗ 2 (encoding HNA-5b) alleles were 0.72 and 0.28, respectively. In the studied population, HNA-2 antigen was present on the neutrophil surface in 97.3% of the individuals, while no detectable HNA-2 expression was observed in 2.7% of the individuals. However, no significant difference in HNA-2 expression between different age groups was found. Conclusion. The present study provides the first report of the HNA allele and genotype frequencies among the Iranian population. All HNAs (HNA-1 to HNA-5) were typed using the PCR-SSP and flow cytometer. In the current cohort study, the determined HNA allele frequencies were similar to the previous reports from British, German, and Danish populations. Considering the presence of different Iranian ethnic groups, further studies with a larger sample size are needed to draw a total picture for HNA allele frequencies.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Esmaeili

Bayat

Alirezaee

et al. 2022

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…Owing to their clinical relevance, variant and genotype frequencies of HNAs have been studied among various global populations including Iranian 13 , Japanese 14 , Malays, Chinese 15 , Hong Kong 16 , Thai 17 , Turkish, German 18 , African American 19,20 , Danish and Zambian 21 .…”

Section: Introductionmentioning

confidence: 99%

Genetic landscape of Human neutrophil antigen variants in India from population-scale genomes

Rophina

Bhoyar

Imran

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Antibodies against human neutrophil antigens (HNAs) play a significant role in various clinical conditions such as neonatal alloimmune neutropenia (NAIN). Transfusion-related acute lung injury (TRALI) and other non-hemolytic transfusion reactions. This study aims to identify the genotype and allele frequencies of HNAs in the healthy Indian population. Methods: Genetic variants from whole genomes of 1029 healthy Indian individuals were retrieved to accurately perform frequency estimation of HNA-1, HNA-3, HNA-4 and HNA-5 alleles using in-house computational pipeline. Results: In HNA class I, the genotype frequencies of FCGR3B*01 (HNA1a/a), FCGR3B*02 (HNA1b/b) and FCGR3B*03 (HNA1c/c) were 0.29%, 27.31% and 1.75% respectively. In HNA-3 the frequencies of HNA3a/a (SLC44A2*01), HNA3a/b and HNA3b/b (SLC44A2*02) were found to be 62.0%, 31.7% and 5.8% respectively. Frequency of ITGAM*01 encoding HNA4a/a was 90.1% and that of ITGAM*02 encoding HNA4b/b was 0.3%. Furthermore, HNA5a/a (ITGAL*01) and HNA5b/b (ITGAL*02) were found to have 12.9% and 48.6% genotype frequencies in the Indian population respectively. It was also found that the allele frequency HNA-5 variant, rs2230433 (ITGAL_chr16:30506720G>C) encoding 5b allele was highly prevalent (78.2%) in the Indian population which was comparable to South Asians (65.6%) but differed greatly from East Asians (14.3%), Latino Americans (25.7%), African-Americans (42.2%), European-Finnish (25.4%), European-non-Finnish (29.4%), Greater Middle Easterners (34.5%), Amish (30.2%) and Ashkenazi Jewish (31.4%). Conclusion: This study presents the first comprehensive report of HNA variant and genotype frequencies using large scale representative whole genome sequencing data of the Indian population. Significant difference was observed in the prevalence of HNA5a and HNA5b in India in comparison to other global populations.

show abstract

Human neutrophil antigen‐1, -3, -4, and -5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance

Stimac¹,

Tomičić²,

Bingulac-Popović³

et al. 2023

Transfusion Clinique et Biologique

View full text Add to dashboard Cite

A study of human neutrophil antigen genotype frequencies in Hong Kong

Cited by 7 publications

References 33 publications

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Human Neutrophil Antigen Genotype and Allele Frequencies in Iranian Blood Donors

Genetic landscape of Human neutrophil antigen variants in India from population-scale genomes

Human neutrophil antigen‐1, -3, -4, and -5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance

Contact Info

Product

Resources

About