A Study of Dermabrasion and Chemical Peels in an Animal Model

Abstract

An animal model was designed to compare the histology of the injuries resulting from dermabrasion and various escharotics presently used for face peeling. The results suggest that dermabrasion, although a superficial wounding process, leads to deep dermal and subcutaneous injuries. The deep dermal wound probably accounts for the correction of actinically damaged skin and wrinkling so often seen after dermabrasion. The injuries after peels were proportional to the concentration of the acid used: 50% phenol being stronger than 50% trichloracetic acid, which is stronger than 25% trichloracetic acid. The effects of epideraml irritants such as croton oil, the effects of occlusion, and the dose-dependent responses of phenol are all presented and discussed.

A Case Report of Laser Resurfacing as a Skin Cancer Prophylaxis

“…[18][19][20] Indeed these studies indicated that dermabrasion may ameliorate the number of both future squamous cell and basal cell cancers. [23][24][25][26][27][28] While CO 2 laser vaporization has been used as a treatment for individual skin cancers 29,30 and multiple facial actinic keratoses, 17 a study documenting a benefit of laser resurfacing in terms of cancer prophylaxis has not yet been published. 21 Thus, as has been suggested by other authors, 2,22 resurfacing may effectively remove subclinical, superficial skin cancers and precancers, while simultaneously affording a prophylactic benefit.…”

Chemical Face Peeling Without Taping

“…No one would argue that deeper penetration of peel solution is obtained when occlusive dressings are applied. Stegman 9 has demonstrated this extremely well in both animal models and in recent human studies. These studies also indicate a dose‐dependent response to phenol.…”

Histological evaluation of dermal tissue remodeling with the 1444‐nm neodymium:yttrium–aluminum–garnet laser in in vivo model

“…In our study, the dermal tissue remodeling was observed in in vivo guinea pig models, following the irradiation of the 1444‐nm Nd:YAG laser. Guinea pigs are inexpensive, easy to handle and a reasonable animal model for the human skin …”