volume 278, issue 32, P30115-30124 2003
DOI: 10.1074/jbc.m302443200
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Abstract: The validity of the structure of the Escherichia coli MsbA lipid transporter as a model from the mdr1 Pglycoprotein has been evaluated. Comparative sequence analyses, motif search and secondary structure prediction indicated that each of the two P-glycoprotein halves is structurally similar to the MsbA monomer and also suggested that the open dimer structure is valid for P-glycoprotein. Homology modeling was used to predict the structure of P-glycoprotein using MsbA as a template. The resulting modeled struct…

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