A strategy for the clinical remission of acute lymphoblastic leukemia elicited by treatment of β‑thalassemia major: A case report

Palomo-Colli, Miguel Ángel; Zapata‐Tarrés, Marta; Castelán-Martínez, Osvaldo Daniel; Juárez-Villegas, Luis Enrique; Córdova‐Hurtado, Lourdes P.

doi:10.3892/mco.2017.1533

Cited by 3 publications

(3 citation statements)

References 17 publications

(16 reference statements)

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“…7 The cases included a wide spectrum of hematologic cancers, including HL and NHL, acute lymphoid leukemia, acute promyelocytic leukemia, multiple myeloma (MM), and monoclonal gammopathy of unknown significance. 8,[13][14][15][16][17] Moreover, reports of myeloproliferative neoplasms in thalassemia are present in the literature with cases of chronic myeloid leukemia. A few cases of the rare coincidence of thalassemia and polycythemia vera (PV) have also been reported.…”

Section: Hematologic Malignanciesmentioning

confidence: 99%

“…Over the years, more than 40 cases of different hematologic malignancies have been described in the literature from data of national registries, case series, and case reports 7 . The cases included a wide spectrum of hematologic cancers, including HL and NHL, acute lymphoid leukemia, acute promyelocytic leukemia, multiple myeloma (MM), and monoclonal gammopathy of unknown significance 8,13–17 . Moreover, reports of myeloproliferative neoplasms in thalassemia are present in the literature with cases of chronic myeloid leukemia.…”

Section: Hematologic Malignanciesmentioning

confidence: 99%

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Thalassemia and malignancies: Updates from the literature

Hodroj,

Taher

2023

Annals of the New York Academy of Sciences

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Thalassemia management has undergone significant development with the advancement in iron chelation therapy, which has led to a prolonged life expectancy. This has been accompanied by the emergence of several new morbidities and chronic diseases, including cancer. Over the years, multiple cases of solid and hematologic malignancies in thalassemia patients have been reported in the literature, with no clear mechanism for the development of cancer in these patients despite a number of potential mechanisms. However, the results of many studies have been contradictory regarding the risk of development of malignancies in thalassemia. The present review aims to discuss the available data on cancer and thalassemia in the literature, with the latest updates regarding possible malignancy development mechanisms, risks, and the most commonly reported types.

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Section: Hematologic Malignanciesmentioning

confidence: 99%

Section: Hematologic Malignanciesmentioning

confidence: 99%

Thalassemia and malignancies: Updates from the literature

Hodroj,

Taher

2023

Annals of the New York Academy of Sciences

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“…People with β-thalassemia major commonly present with severe anemia within the first 2 years of life and need regular red blood cell transfusions. 13…”

Section: Introductionmentioning

confidence: 99%

A Case Report of Down Syndrome and β-Thalassemia Major Coincidence

Mirhosseini,

Mirhosseini

2023

WJPN

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Background: Down syndrome and β-thalassemia are commonly prevalent genetic diseases worldwide. Predominantly, an extra copy of chromosome 21 or trisomy 21 predominantly causes Down syndrome (the most common genetic etiology of moderate intellectual disability). Down syndrome is associated with congenital anomalies and characteristic features. β-thalassemia major or transfusion- dependent thalassemia refers to a severe expression of the disorder that requires early transfusion therapy. Case Report: Here, we reported a male Down syndrome patient with a 47, xy, +21 karyotype who was diagnosed with β-thalassemia major at 6 months and treated with repeated transfusions every 20 days due to anemia. Conclusion: The association between Down syndrome and major β-thalassemia is rare. The severity of the presentation of the child may be explained by the coincidence of these diseases

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Acute Promyelocytic Leukemia in a Woman with Thalassemia Intermedia: Case Report and Review of Literature on Hematological Malignancies in β-Thalassemia Patients

et al. 2022

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Patients affected by transfusion-dependent β-thalassemia are prone to developing several clinical complications, mostly related to the iron overload. We report the case of a patient affected by transfusion-dependent β-thalassemia (TDT) developing acute promyelocytic leukemia (APL). In our case, the therapeutic management was significantly complicated not only by myocardial dysfunction, but also by the occurrence of the differentiation syndrome following all-trans retinoic acid (ATRA) administration. We carried out a careful revision of the current literature on the occurrence of hematological malignancies in β-thalassemia patients to investigate the major complications so far described. APL occurrence in β-thalassemia patients has been very rarely reported, and our experience suggests that TDT patients suffering pre-existing comorbidities may develop a potentially fatal complication during ATRA therapy.

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A strategy for the clinical remission of acute lymphoblastic leukemia elicited by treatment of β‑thalassemia major: A case report

Cited by 3 publications

References 17 publications

Thalassemia and malignancies: Updates from the literature

Thalassemia and malignancies: Updates from the literature

A Case Report of Down Syndrome and β-Thalassemia Major Coincidence

Acute Promyelocytic Leukemia in a Woman with Thalassemia Intermedia: Case Report and Review of Literature on Hematological Malignancies in β-Thalassemia Patients

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