2012
DOI: 10.1002/adma.201104589
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Abstract: The fabrication of tubular structures, with multiple cell types forming different layers of the tube walls, is described using a stress-induced rolling membrane (SIRM). Cell orientation inside the tubes can also be controlled by topographical contact guidance. These layered tubes precisely mimic blood vessels and many other tubular structures, suggesting that they may be of great use in tissue engineering.

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Cited by 226 publications
(191 citation statements)
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“…28,29 After the polydimethylsiloxane (PDMS) slab was peeled off from the mold, four ports at the inlet and outlets were punched through the PDMS with a flat tip needle. The PDMS slab was then bonded with a glass substrate (25 mm  75 mm) post oxygen plasma treatment.…”
Section: Methodsmentioning
confidence: 99%
“…28,29 After the polydimethylsiloxane (PDMS) slab was peeled off from the mold, four ports at the inlet and outlets were punched through the PDMS with a flat tip needle. The PDMS slab was then bonded with a glass substrate (25 mm  75 mm) post oxygen plasma treatment.…”
Section: Methodsmentioning
confidence: 99%
“…Limitations to the present method include: (1) microfluidic patterning is incompatible with certain complex 3D structures, such as layer-by-layer assembly to mimic in vivo-like tissues; 16,17 (2) dynamic and continuous nutrient supply and waste removal to mimic the physiological microenvironments could not be easily achieved with the current proposed design (although this drawback could be overcome by integrating with an evaporation-based micropump 36 ). However, the new capabilities allowed by the combination of techniques reported here (for example, the perforated membrane deterministically enabling cell trapping and in-situ generation of uniformly sized spheroids) may enable studies in 3D modeling of complex metastatic cascade (see results for the migration of tumor cells in 3D matrices in Supplementary Figure S7) and drug screening for metastatic cancers in 3D (via delivery of drugs diffused across the perforated cell culture areas 9 ).…”
Section: Configurable 2d Cell Patterningmentioning
confidence: 99%
“…10 Various techniques for patterning cells in 2D or 3D tissue culture have demonstrated the ability to direct cells onto selected areas of a surface, including microcontact printing 8 or soft lithography, 1 microfluidic-or microstructure-based methods, 11,12 active control of cell attachment or suspension by physical forces [13][14][15] and layer-bylayer assembly. 16,17 However, challenges still remain. For example, some techniques typically require a substantial amount of cells to seed onto open surfaces and wash away numerous unattached cells after the cell-patterning step has been executed.…”
Section: Introductionmentioning
confidence: 99%
“…Recent technological advances in engineering three dimensional (3D) cell cultures have demonstrated prominent improvement in approximation of cell-cell interactions and microenvironmental conditions in vivo, which play a great role in the field of tissue engineering [1][2][3][4][5][6][7][8][9][10][11]. Among them, microcarriers have emerged as novel biomimetic platforms, which offer 3D biomaterial scaffolds for cell encapsulation and aggregate formation [10][11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%