A strategy for attenuation of acute radiation-induced lung injury using crocetin from gardenia fruit

Ding, Yan; Ma, Lei; He, Ling; Qian, Xu; Zhang, Zhuang; Zhang, Zhen; Fan, Rui; Ma, Wei; Sun, Yanan; Zhang, Baile; Li, Wentai; Zhai, Yongjie; Zhang, Jiandong

doi:10.1016/j.biopha.2022.112899

Cited by 8 publications

(5 citation statements)

References 50 publications

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“…Similarly, investigations on IR-induced ferroptosis in radiation injury have primarily concentrated on intestinal injury [81][82][83][84], lung injury [85][86][87][88], with limited studies on hematopoietic system injury [89,90], wound repair [91], hippocampus neurons injury [92], and skin injury [93]. Research on radiation-induced necroptosis in the field of radiation injury primarily focuses on lung injury [94] and intestinal injury [95].…”

Section: Radiation-induced Pyroptosis/ferroptosis/ Necroptosis and Do...mentioning

confidence: 99%

“…Plant extracts, such as crocetin derived from gardenia fruit and lipoxygenase-15 derived from baicalein, exhibit potential as radioprotective drugs (Figure 5 ) . Crocetin alleviates radiation injury to lung tissue structure by inhibiting the expression of Tnfrsf10b, thereby hindering the occurrence of necroptosis 94 . Greenberger et al reported that lipoxygenase-15, along with the classic necroptosis inhibitor necrostatin-1 can inhibit necroptosis and extend the survival of radiation-damaged animals 124 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury

Ning,

Chen,

Zeng

et al. 2024

Int. J. Biol. Sci.

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Radiotherapy (RT) stands as the primary treatment for tumors, but it inevitably causes damage to normal cells. Consequently, radiation injury is a crucial consideration for radiation oncologists during therapy planning. Cell death including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis play significant roles in tumor treatment. While previous studies elucidated the induction of apoptosis and autophagy by ionizing radiation (IR), recent attention has shifted to pyroptosis, ferroptosis, and necroptosis, revealing their effects induced by IR. This review aims to summarize the strategies employed by IR, either alone or in combination therapy, to induce pyroptosis, ferroptosis, and necroptosis in radiation injury. Furthermore, we explore their effects and molecular pathways, shedding light on their roles in radiation injury. Finally, we summarize the regulative agents for these three types of cell death and their mechanisms. In summary, optimizing radiation dose, dose rate, and combined treatment plans to minimize radiation damage and enhance the killing effect of RT is a key focus.

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Section: Radiation-induced Pyroptosis/ferroptosis/ Necroptosis and Do...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury

Ning,

Chen,

Zeng

et al. 2024

Int. J. Biol. Sci.

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“…Receptors such as TNFR1, TRAIL-R1, and TNFRSF10B, when bound to members of the TNF superfamily, initiate necroptosis [ 189 , 190 , 191 , 192 ]. Studies have found that crocetin inhibits necroptosis by downregulating the Tnfrsf10b gene at the transcriptional level, providing good protection in a mouse model of radiation-induced lung injury [ 193 ]. In a study by Almodóvar et al, the maximal concentration of crocetin in the blood of 13 healthy human volunteers was detectable approximately 60–90 min after the ingestion of different concentrations of Gardenia extract, showing a dose-dependent pharmacokinetic response [ 194 ].…”

Section: Pharmacological Interventions Against Necroptosis In Pneumoniamentioning

confidence: 99%

Necroptosis in Pneumonia: Therapeutic Strategies and Future Perspectives

Mei,

Zhang,

Wang

et al. 2024

Viruses

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Pneumonia remains a major global health challenge, necessitating the development of effective therapeutic approaches. Recently, necroptosis, a regulated form of cell death, has garnered attention in the fields of pharmacology and immunology for its role in the pathogenesis of pneumonia. Characterized by cell death and inflammatory responses, necroptosis is a key mechanism contributing to tissue damage and immune dysregulation in various diseases, including pneumonia. This review comprehensively analyzes the role of necroptosis in pneumonia and explores potential pharmacological interventions targeting this cell death pathway. Moreover, we highlight the intricate interplay between necroptosis and immune responses in pneumonia, revealing a bidirectional relationship between necrotic cell death and inflammatory signaling. Importantly, we assess current therapeutic strategies modulating necroptosis, encompassing synthetic inhibitors, natural products, and other drugs targeting key components of the programmed necrosis pathway. The article also discusses challenges and future directions in targeting programmed necrosis for pneumonia treatment, proposing novel therapeutic strategies that combine antibiotics with necroptosis inhibitors. This review underscores the importance of understanding necroptosis in pneumonia and highlights the potential of pharmacological interventions to mitigate tissue damage and restore immune homeostasis in this devastating respiratory infection.

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“…Natural polyphenols have attracted much attention in the radioprotective field for their potent ROS-scavenging ability [9][10][11][12][13]. Curcumin (Cur), a natural polyphenolic compound extracted from turmeric (Curcuma longa), is known for its various pharmacological functions, including robust anti-inflammatory and antioxidative properties [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Oral Curcumin–Thioketal–Inulin Conjugate Micelles against Radiation–Induced Enteritis

Shen,

Jiao,

Yuan

et al. 2024

Antioxidants

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Radiation–induced enteritis is an unavoidable complication associated with pelvic tumor radiotherapy, significantly influencing the prognosis of cancer patients. The limited availability of commercial gastrointestinal radioprotectors in clinical settings poses a substantial challenge in preventing radiation enteritis. Despite the inherent radioprotective characteristics of Cur in vitro, its poor solubility in water, instability, and low bioavailability lead to inferior therapeutic effects in vivo. Herein, we developed novel ROS-responsive micelles (CTI) from inulin and curcumin, aimed at mitigating radiation enteritis. CTI micelles had excellent solubility and stability. Importantly, CTI improved the cytotoxicity and bioavailability of curcumin, thereby showing enhanced effectiveness in neutralizing ROS induced by radiation, safeguarding against DNA damage, and reducing radiation-induced cellular mortality. Moreover, in a radiation enteritis mice model, CTI not only alleviated severe radiation-induced intestinal injury but also improved redox-related indicators and reduced inflammatory cytokine expression. Furthermore, CTI effectively increased gut microbiota abundance and maintained gut homeostasis. In conclusion, CTI could be a promising candidate for the clinical management of radiation enteritis. Our study provides a new perspective for radioprotection using natural antioxidants.

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A strategy for attenuation of acute radiation-induced lung injury using crocetin from gardenia fruit

Cited by 8 publications

References 50 publications

The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury

The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury

Necroptosis in Pneumonia: Therapeutic Strategies and Future Perspectives

Oral Curcumin–Thioketal–Inulin Conjugate Micelles against Radiation–Induced Enteritis

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