A standardized model to study effects of varying 24-h colostrum dose on postnatal growth and development

Abstract

Survival, feed efficiency, growth and fertility of swine are dependent on colostrum intake in the first 24 h after birth. This study determined the effects of three doses of a homogeneous colostrum sample on 24 h body weight, rectal temperature (RT), immunocrit, and growth and survival to postnatal day (PND) 7. Three female piglets were selected from 8 litters (n = 24 piglets) at birth, removed from their litter, and bottle-fed 10% (COL10, n = 8), 15% (COL15, n = 8) or 20% (COL20, n = 8) colostrum based on birth weight over 12 bottle feedings every 2 h. At 24 h, piglets were weighed, RT recorded and blood was collected to measure immunocrit. Piglets were returned to litter of origin and weight was measured daily until PND 7. Colostrum dose had an overall effect on weight gain at 24 h, RT, immunocrit, and growth to PND 7 (P<0.05). Piglets in the 20% BrW colostrum group had greater weight gain, RT and immunocrit at 24 h than COL10 piglets (P<0.05), but these variables were not different between COL15 and the other treatments. Despite no difference in average daily gain after being returned to their litters, the greater weight (P<0.05) in COL20 compared to COL10 and COL15 was sustained over 7 days. Seven piglets in each treatment survived to PND 7. This model using standardized doses of a homogeneous colostrum sample enables controlled studies aimed at understanding the role of 24 h colostrum intake on piglet development.

Euglena gracilis β-Glucans (1,3): Enriching Colostrum of Sow for Enhanced Piglet Immunity

“…The greater colostrum production observed determined a higher intake of colostrum by piglets during the first 18 h of life (Table 3), which is a condition that has determining effects on their health [23,29,32,33]. In this perspective, piglets consuming 20% of their birth weight in colostrum are satisfactorily supplied with energy and nutrients to increase their body mass and maintain homeothermy [34].…”

Mammary Development in Gilts at One Week Postnatal Is Related to Plasma Lysine Concentration at 24 h after Birth, but Not Colostrum Dose

“…The lack of an effect may also have been related to the study design. Different doses of colostrum resulted in COL20 animals weighing significantly more after the 24 h of colostrum feeding, and these differences were maintained to postnatal day seven [13]. However, returning piglets to birth litters likely had unmeasured impacts on perinatal nutrition.…”

“…The overall goal of this study was to test this hypothesis and determine the relationship between the level of colostrum intake and 24 h level of circulating amino acid, glucose and insulin with mammary parenchyma histological features, as well as cell division and protein synthesis over the first postnatal week. For the described studies, one of two standardized doses of a homogenate colostrum sample, 10% and 20% of birth bodyweight, was fed to study animals [13]. Gilts were given a bolus of heavy water (deuterium oxide) immediately after birth and daily for seven days to label newly synthesized DNA and protein over this time period.…”

“…Animals used for the study were born at the Purdue University Animal Sciences Research and Education Center Swine Farm to eight York (×) Landrace multiparous (3.25 ± 1.67 parities) sows bred to terminal sire Duroc boars. Sixteen animals (n = 16) used for the investigations were part of a larger study [13]. Animals were selected at birth from across eight different litters (n = 2 gilts/litter; birth litter size was 12.3 ± 1.3 live piglets/sow).…”

Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions

“…The stock solution was diluted ten times into injection solvent spiked with 0.1 ng/μl of EquiSPLASH Lipidomics (Avanti Polar Lipids, AL, United States #330731) for sample injection. The MRM-profiling methods and instrumentation used have been recently described in previous reports ( de Lima et al, 2018 ) ( Dipali et al, 2019 ) ( Suárez-Trujillo et al, 2020 ) ( Clyde-Brockway et al, 2021 ). In summary, data acquisition was performed using flow injection (no chromatographic separation) from 8 μl of the diluted lipid extract stock solution delivered using a micro-autosampler (G1377A) to the ESI source of an Agilent 6410 triple quadrupole mass spectrometer (Agilent Technologies, Santa Clara, CA, United States).…”