A SPECT imager with synthetic collimation

Havelin, Ronan J.; Miller, Brian W.; Barrett, Harrison H.; Furenlid, Lars R.; Murphy, Mary; Foley, Mark

doi:10.1117/12.2029745

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…This indicates that a high field of view (FOV) sampling is very important, and several groups have successfully combined multiplexing and high sampling [ 14 , 15 , 16 ]. Another solution consists in obtaining a high number of projections at different distances from the object (synthetic collimation) [ 17 ]. Coded aperture masks have also been proposed to increase the sensitivity and at the same time maintain a good spatial resolution [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study

Ilisie

Moliner

Morera

et al. 2021

Sensors

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In this work, we propose and analyze a new concept of gamma ray imaging that corresponds to a gamma camera with a mobile collimator, which can be used in vivo, during surgical interventions for oncological patients for localizing regions of interest such as tumors or ganglia. The benefits are a much higher sensitivity, better image quality and, consequently, a dose reduction for the patient and medical staff. This novel approach is a practical solution to the overlapping problem which is inherent to multi-pinhole gamma camera imaging and single photon emission computed tomography and which translates into artifacts and/or image truncation in the final reconstructed image. The key concept consists in introducing a relative motion between the collimator and the detector. Moreover, this design could also be incorporated into most commercially available gamma camera devices, without any excessive additional requirements. We use Monte Carlo simulations to assess the feasibility of such a device, analyze three possible designs and compare their sensitivity, resolution and uniformity. We propose a final design of a gamma camera with a high sensitivity ranging from 0.001 to 0.006 cps/Bq, and a high resolution of 0.5–1.0 cm (FWHM), for source-to-detector distances of 4–10 cm. Additionally, this planar gamma camera provides information about the depth of source (with approximate resolution of 1.5 cm) and excellent image uniformity.

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Section: Introductionmentioning

confidence: 99%

Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study

Ilisie

Moliner

Morera

et al. 2021

Sensors

View full text Add to dashboard Cite

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Functional imaging for regenerative medicine

et al. 2016

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In vivo imaging is a platform technology with the power to put function in its natural structural context. With the drive to translate stem cell therapies into pre-clinical and clinical trials, early selection of the right imaging techniques is paramount to success. There are many instances in regenerative medicine where the biological, biochemical, and biomechanical mechanisms behind the proposed function of stem cell therapies can be elucidated by appropriate imaging. Imaging techniques can be divided according to whether labels are used and as to whether the imaging can be done in vivo. In vivo human imaging places additional restrictions on the imaging tools that can be used. Microscopies and nanoscopies, especially those requiring fluorescent markers, have made an extraordinary impact on discovery at the molecular and cellular level, but due to their very limited ability to focus in the scattering tissues encountered for in vivo applications they are largely confined to superficial imaging applications in research laboratories. Nanoscopy, which has tremendous benefits in resolution, is limited to the near-field (e.g. near-field scanning optical microscope (NSNOM)) or to very high light intensity (e.g. stimulated emission depletion (STED)) or to slow stochastic events (photo-activated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM)). In all cases, nanoscopy is limited to very superficial applications. Imaging depth may be increased using multiphoton or coherence gating tricks. Scattering dominates the limitation on imaging depth in most tissues and this can be mitigated by the application of optical clearing techniques that can impose mild (e.g. topical application of glycerol) or severe (e.g. CLARITY) changes to the tissue to be imaged. Progression of therapies through to clinical trials requires some thought as to the imaging and sensing modalities that should be used. Smoother progression is facilitated by the use of comparable imaging modalities throughout the discovery and trial phases, giving label-free techniques an advantage wherever they can be used, although this is seldom considered in the early stages. In this paper, we will explore the techniques that have found success in aiding discovery in stem cell therapies and try to predict the likely technologies best suited to translation and future directions.

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A SPECT imager with synthetic collimation

Cited by 2 publications

References 25 publications

Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study

Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study

Functional imaging for regenerative medicine

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