A SPECT camera for simultaneous SPECT/MRI

Meier, Dirk; Wagenaar, Douglas J.; Mahlum, Gunnar; Sundal, B.; Patt, Bradley E.; Chen, Si; Xu, Jingyan; Yu, Jianzhong; Tsui, B.M.W.; Hamamura, Mark J; Roeck, Werner W.; Ha, Seunghoon; Nalcioğlu, Orhan

doi:10.1109/nssmic.2009.5402269

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…Solid-state technologies can be expensive alternatives but have also proved to be advantageous in stand-alone PET systems: silicon photomultiplier (SiPM) based systems have improved spatial resolution and superior time resolution [9] [10] for time-of-flight (ToF) PET. Some preclinical SPECT systems have adopted alternative solid-state technology (cadmium zinc telluride (CZT) detectors), [11], [12], but no clinical detectors have been designed with MRI compatibility in mind.…”

Section: Spect-mri Systemsmentioning

confidence: 99%

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Morahan

D’Adda

Erlandsson

et al. 2023

IEEE Trans. Radiat. Plasma Med. Sci.

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The INSERT is the world's first clinical SPECT-MRI brain imaging system based on scintillation detectors with a SiPM readout. Here we demonstrate its use within a clinical MRI environment for the first time. Using a standard transmit-receive head coil, and with an appropriate selection of a custom MRI sequence (GRE), we overcome mutual interference. The INSERT and its bulky 50 kg tungsten collimator introduce magnetic field inhomogeneity. Due to the specific MRI-compatible collimator design, inhomogeneity is compensated by shimming, leading to simultaneous acquisition. We process the SPECT data acquired alongside the MRI sequence to evaluate the SPECT system performance and the impact of the MRI. Finally, we present a set of simultaneous SPECT-MRI acquisitions, demonstrating multimodal imaging capabilities, albeit with a limited MRI sequence.

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Section: Spect-mri Systemsmentioning

confidence: 99%

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Morahan

D’Adda

Erlandsson

et al. 2023

IEEE Trans. Radiat. Plasma Med. Sci.

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“…A first generation MR-compatible SPECT prototype was designed and constructed previously to fit inside a MRI system with a minimum gradient bore inner diameter of 12 cm [2,3]. As shown in Fig.…”

Section: First Generation Mr-compatible Spect Prototypementioning

confidence: 99%

Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals

Tsui

Hugg

et al. 2011

SPIE Proceedings

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We describe a continuing design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals. A first generation prototype SPECT system was designed and constructed to fit inside a MRI system with a gradient bore inner diameter of 12 cm. It consists of 3 angularly offset rings of 8 detectors (1"x1", 16x16 pixels MR-compatible solid-state CZT). A matching 24-pinhole collimator sleeve, made of a tungsten-compound, provides projections from a common FOV of ~25 mm. A birdcage RF coil for MRI data acquisition surrounds the collimator. The SPECT system was tested inside a clinical 3T MRI system. Minimal interference was observed on the simultaneously acquired SPECT and MR images. We developed a sparse-view image reconstruction method based on accurate modeling of the point response function (PRF) of each of the 24 pinholes to provide artifact-free SPECT images. The stationary SPECT system provides relatively low resolution of 3-5 mm but high geometric efficiency of 0.5-1.2% for fast dynamic acquisition, demonstrated in a SPECT renal kinetics study using Tc-99m DTPA. Based on these results, a second generation prototype MR-compatible SPECT system with an outer diameter of 20 cm that fits inside a mid-sized preclinical MRI system is being developed. It consists of 5 rings of 19 CZT detectors. The larger ring diameter allows the use of optimized multi-pinhole collimator designs, such as high system resolution up to ~1 mm, high geometric efficiency, or lower system resolution without collimator rotation. The anticipated performance of the new system is supported by simulation data.

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“…Most notably, Wagenaar et al have reported the design considerations of an MRI compatible SPECT system based on CZT detectors [11]. Tsui et al have presented a prototype of a MRI compatible SPECT system based on similar CZT detectors [12]. A consortium consisting of several groups in EU proposed and developed both preclinical and clinical SPECT inserts using SiPM based detector [13, 14, 15, 16].…”

Section: Introductionmentioning

confidence: 99%

Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design

Lai

Meng

2018

Phys. Med. Biol.

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In this paper, we present simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consists of a total of 1536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diameter of 6 cm. This system provides a FOV of 1 cm diameter and a peak geometrical efficiency of approximately 1.3% (the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining a sub-500 μm spatial resolution. Compared to the first-generation MRC-SPECT system (MRC-SPECT-I) (Cai 2014 Nucl. Instrum. Methods Phys. Res. A 734 147-51) developed in our lab, the MRC-SPECT-II system offers a similar resolution with dramatically improved sensitivity and greatly reduced physical dimension. The latter should allow the system to be placed inside most clinical and pre-clinical MRI scanners for high-performance simultaneous MRI and SPECT imaging.

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A SPECT camera for simultaneous SPECT/MRI

Cited by 12 publications

References 21 publications

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals

Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design

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