A solitary, erythematous, hyperkeratotic papule. Acantholytic acanthoma

Dj, Barnette; Cobb, Mark W.

doi:10.1001/archderm.131.2.211b

Cited by 7 publications

(3 citation statements)

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“…Our review includes 30 patients with cutaneous acantholytic dyskeratotic acanthoma and 3 patients with subungual acantholytic dyskeratotic acanthoma (Table 1) [1,17–20,23]. Their onset age ranged from 39 years to 84 years with a median of 54 years.…”

Section: Discussionmentioning

confidence: 99%

Acantholytic dyskeratotic acanthoma: case report and review of the literature

Goldenberg

Lee

Cohen³

2014

Dermatol Pract Concept

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Background:Focal acantholytic dyskeratosis has been described as an incidental finding and as a clinically distinct lesion. In both situations, a dimorphic histologic pattern is observed: acantholysis and dyskeratosis. Solitary, non-genital lesions displaying such pathology have been difficult to classify. Clinical and pathological characteristics of acantholytic dyskeratotic acanthomas are described.Methods:The features of a patient with solitary, non-genital, acantholytic dyskeratotic acanthoma are presented and the literature on acantholytic dyskeratotic acanthomas is reviewed. Using PubMed the following terms were searched and relevant citations assessed: acantholysis, acanthoma, cutaneous, dyskeratosis, nail, warty.Results:We identified 30 cutaneous acantholytic dyskeratotic acanthomas, including our patient, most often found on the trunk and mimicking basal cell carcinoma, and three subungual acantholytic dyskeratotic acanthomas of the thumb, which mimicked onychopapilloma.Conclusion:Acantholytic dyskeratotic acanthomas are clinically and pathologically distinct lesions, which may morphologically present as either truncal plaques or subungual longitudinal erythronychia.

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Section: Discussionmentioning

confidence: 99%

Acantholytic dyskeratotic acanthoma: case report and review of the literature

Goldenberg

Lee

Cohen³

2014

Dermatol Pract Concept

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“…Indeed, one case report of a solitary acantholytic acanthoma on the abdomen briefly mentions that mild dyskeratosis may be present, but Ôprominent' dyskeratosis is not a feature. 2 Although clinically apparent, non-genital lesions that histologically display prominent acantholysis and dyskeratosis are not uncommon lesions, nomenclature is not standardized. Some dermatopathology textbooks classify these lesions as acantholytic acanthomas, 3,4,5 referencing articles that describe papular acantholytic dyskeratosis of the genital area.…”

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confidence: 99%

Acantholytic dyskeratotic acanthoma: a variant of a benign keratosis

Barr

Subtil

et al. 2007

J Cutan Pathol

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Acantholytic acanthoma was originally described as a solitary lesion displaying histologic features of acantholysis without dyskeratosis. Solitary, non-genital lesions displaying confluent acantholysis and dyskeratosis have not been well described in the literature, clinically or histologically. We screened cases at our institution over a 6-month period and found 28 such lesions. Lesions were most often found on the trunk as a solitary papule, for which the clinical diagnosis was often basal cell carcinoma. There was a slight female predominance. Confluent acantholysis and dyskeratosis is a histologic pattern that may present as a solitary keratosis.

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“…This case is interesting because it clinically resembled a molluscum contagiosum, demonstrating a dome‐shaped appearance and central umbilication. Such a clinical picture has been described only once 3 . The cause of acantholytic acanthoma is unknown; however, Ramos‐Caro et al 4 .…”

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confidence: 99%