A smart nanosensor for the detection of human immunodeficiency virus and associated cardiovascular and arthritis diseases using functionalized graphene-based transistors

Islam, Saurav; Shukla̽, Shruti; Bajpai, Vivek K.; Han, Young‐Kyu; Huh, Yun Suk; Kumar, Ashok; Ghosh, Arindam; Gandhi, Sonu

doi:10.1016/j.bios.2018.11.041

Cited by 121 publications

(84 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MoS 2 is one of the most important members of the transition metal-dichalcogenide family, and has found numerous applications in electronics, optoelectronics, piezoelectricity, and valleytronics [7,[19][20][21][22][23]. The diverse properties of these materials have been best exploited by fabricating hybrids out of them, by stacking one on top of the other, leading to state-of-the-art sensors, and providing a solid platform for further miniaturization of devices and faster electronics [8,9,16,18,19,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”

mentioning

confidence: 99%

A generic method to control hysteresis and memory effect in Van der Waals hybrids

Ahmed¹,

Islam²,

Paul³

et al. 2020

Mater. Res. Express

Self Cite

View full text Add to dashboard Cite

The diverse properties of two-dimensional materials have been utilized in a variety of architecture to fabricate high quality electronic circuit elements. Here we demonstrate a generic method to control hysteresis and stable memory effect in Van der Waals hybrids with a floating gate as the base layer. The floating gate can be charged with a global back gate-voltage, which it can retain in a stable manner. Such devices can provide a very high, leakage-free effective gate-voltage on the field-effect transistors due to effective capacitance amplification, which also leads to reduced input power requirements on electronic devices. The capacitance amplification factor of ∼10 can be further enhanced by increasing the area of the floating gate. We have exploited this method to achieve highly durable memory action multiple genre of ultra-thin 2D channels, including graphene, MoS 2 , and topological insulators at room temperature.

show abstract

mentioning

confidence: 99%

A generic method to control hysteresis and memory effect in Van der Waals hybrids

Ahmed¹,

Islam²,

Paul³

et al. 2020

Mater. Res. Express

Self Cite

View full text Add to dashboard Cite

show abstract

“…To meet this requirement, aptamer (as a biorecognition element) based detection has recently increased in demand, due to its higher specificity and lesser cross reactivity as compared to antibodies, as well as ease of production 12,21 . Microfluidic devices are gaining importance as cheap, mass producible, and ecofriendly which can be used as an alternative technology for on-site detection of Afl M1 [22][23][24][25] .…”

mentioning

confidence: 99%

Fabrication of microfluidic device for Aflatoxin M1 detection in milk samples with specific aptamers

Kasoju

Shahdeo

Khan

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

This study describes the colorimetric detection of aflatoxin M1 (Afl M1) in milk samples using a microfluidic paper-based analytical device (µPAD). Fabrication of µPADs was done using a simple and quick approach. Each μPAD contained a detection zone and a sample zone interconnected by microchannels. The colorimetric assay was developed using unmodified AuNPs as a probe and 21-mer aptamer as a recognition molecule. The free aptamers were adsorbed onto the surface of AuNPs in absence of Afl M1, even at high salt concentrations. The salt induced aggregation of specific aptamers occurred in presence of Afl M1. Under optimum conditions, the analytical linear range was found to be 1 µM to 1 pM with limit of detection 3 pM and 10 nM in standard buffer and spiked milk samples respectively. The proposed aptamer based colorimetric assay was repeatable, quick, selective, and can be used for on-site detection of other toxins in milk and meat samples. Mycotoxins are secondary metabolites produced by filamentous fungi belonging to the genera Aspergillus and Penicillium 1. Mycotoxins are also found in animal derived foods such as milk due to intake of contaminated feed 2,3. Considering agricultural and economical aspects and possible implications on public health, the most relevant mycotoxins are aflatoxins, ochratoxins, fuminosins, T-2 toxin, and zearalenone (ZEA) 4. Aflatoxins pose a huge economic burden as they cause around 25% or more loss of the world's food crops every year 5. Afl M1 (4-hydroxy aflatoxin B1) and M2 (4-dihydroxy aflatoxin B1) have well proven carcinogenic and mutagenic potentiality and pose severe health consequences on milk consumers, including the risk of cancer and stunted growth in children below the age of 5 years 6. When B1 is ingested by a cow, it is secreted as hydroxylated metabolite aflatoxin M1 (Afl M1) in the urine and milk of the cow 7. Consumption of food containing aflatoxin concentrations of one milligram/kilogram or higher has been suspected to cause aflatoxicosis 8 , the prognosis of which consists of acute liver failure, jaundice, lethargy, and nausea, eventually leading to death within 1 to 2 weeks, based on past reports 9. Thus there is a need to develop rapid low cost technology based highly specific methods for detection of aflatoxins to improve surveillance and control in rural areas. A plethora of analytical techniques are available for aflatoxin M1 detection, ranging from chromatography and HPLC-MS used for regulatory control in official laboratories to rapid test kits for grain silos and farmers, especially for surveys when outbreaks occur 10,11. Conventional techniques for the detection of aflatoxins include gas chromatography (GC), fluorescence or UV based detection, thin layer chromatography (TLC) and enzyme linked immunosorbent assay (ELISA) 6-12. These techniques are routinely used and yield reliable results, however they are expensive, time consuming, require large scale instrumentation and large amounts of hazardous chemical reagents. Advancement in the development of bios...

show abstract

“…Biosensors are devices used to detect the presence or concentration of a biological analyte, such as narcotic drugs, pesticides, or infectious disease biomarkers. 3,[16][17][18][19][20][21][22][23][24] To meet this requirement, paper based microuidic devices have gained importance. Recently, micro-uidic paper-based analytical devices (mPAD) have been demonstrated as a low-cost alternative to glass and polymer substrates for fabrication.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic paper device for rapid detection of aflatoxin B1 using an aptamer based colorimetric assay

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

A smart nanosensor for the detection of human immunodeficiency virus and associated cardiovascular and arthritis diseases using functionalized graphene-based transistors

Cited by 121 publications

References 57 publications

A generic method to control hysteresis and memory effect in Van der Waals hybrids

A generic method to control hysteresis and memory effect in Van der Waals hybrids

Fabrication of microfluidic device for Aflatoxin M1 detection in milk samples with specific aptamers

Microfluidic paper device for rapid detection of aflatoxin B1 using an aptamer based colorimetric assay

Contact Info

Product

Resources

About