A single-molecular ruthenium(<scp>ii</scp>) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy

Li, Qianqian; Liu, Yishen; Zhao, Bingshan; Lei, Jiapeng; Lu, Siyu; Gong, Wanxia; Liang, Ke; Wu, Junzhu; Hong, Xuechuan; Xiao, Yuling

doi:10.1039/d2cc00082b

Cited by 13 publications

(8 citation statements)

References 31 publications

(33 reference statements)

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“…In this way, it is possible to reject the excitation light by an accurate design of the filter band, and have at the same time the maximum transmittance at the molecule re-emission wavelength. Ruthenium-based fluorophores are very appealing to this aim, since the absorption of these complexes is in the range between ultraviolet (UV) and blue light, while the re-emission spectra are usually positioned beyond 500 nm [ 73 , 74 ]. In particular, the interferential filter integrated on the presented SoG has been dimensioned, as reported in [ 28 ], to work with the [Ru(phen) 2 (dppz)] 2+ (phen = 1,10-phenanthroline, dppz = dipyrido[3,2-a:2

-c]phenazine), a fluorescent dye that shows an absorption peak around 450 nm, and an emission peak located between 610 and 630 nm.…”

Section: Evaluation Of System Performancesmentioning

confidence: 99%

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

et al. 2022

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In this work, we present a multifunctional Lab-on-Chip (LoC) platform based on hydrogenated amorphous silicon sensors suitable for a wide range of application in the fields of biochemical and food quality control analysis. The proposed system includes a LoC fabricated on a 5 cm × 5 cm glass substrate and a set of electronic boards for controlling the LoC functionalities. The presented Lab-on-Chip comprises light and temperature sensors, a thin film resistor acting as a heating source, and an optional thin film interferential filter suitable for fluorescence analysis. The developed electronics allows to control the thin film heater, a light source for fluorescence and absorption measurements, and the photosensors to acquire luminescent signals. All these modules are enclosed in a black metal box ensuring the portability of the whole platform. System performances have been evaluated in terms of sensor optical performances and thermal control achievements. For optical sensors, we have found a minimum number of detectable photons of 8 × 104 s−1·cm−2: at room temperature, 1.6 × 106 s−1·cm−2: in presence of fluorescence excitation source, and 2.4 × 106 s−1·cm−2· at 90 °C. From a thermal management point of view, we have obtained heating and cooling rates both equal to 2.2 °C/s, and a temperature sensor sensitivity of about 3 mV/°C even in presence of light. The achieved performances demonstrate the possibility to simultaneously use all integrated sensors and actuators, making promising the presented platform for a wide range of application fields.

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-c]phenazine), a fluorescent dye that shows an absorption peak around 450 nm, and an emission peak located between 610 and 630 nm.…”

Section: Evaluation Of System Performancesmentioning

confidence: 99%

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

et al. 2022

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“…Fluorescence imaging, with the advantages of high spatiotemporal resolution, non-invasiveness, real-time detection, and high sensitivity, is widely used in biomedical and clinical research. − Near-infrared window two (NIR-II, 1000–1700 nm) fluorescence imaging is promising for biological imaging due to the deeper tissue penetration, reduced photon scattering, and diminished tissue autofluorescence. − Small organic molecules have great potential for clinical NIR-II use with their definite chemical structure, easily optimized optical and biological properties, minimal toxicity, and high biocompatibility. , Many small fluorescent molecules have been developed, including BODIPY dyes, rhodamine dyes, cyanine dyes, and D-A-D dyes. − Dyes with a D-A-D skeleton have large Stokes shifts and excellent photophysical stability, having advantages in in vivo fluorescence imaging compared with other small molecule dyes. − …”

Section: Introductionmentioning

confidence: 99%

Hypsochromic Shift Donor–Acceptor NIR-II Dye for High-Efficiency Tumor Imaging

Lei

et al. 2023

J. Med. Chem.

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Nowadays, second near-infrared window (NIR-II) dyes' development focuses on pursuing a longer absorption/emission wavelength and higher quantum yield, which usually means an extended π conjugation system, resulting in an enormous molecular weight and poor druggability. Most researchers thought that the reduced π conjugation system would bring on a blueshift spectrum that causes dim imaging qualities. Little efforts have been made to study smaller NIR-II dyes with a reduced π conjugation system. Herein, we synthesized a reduced π conjugation system donor− acceptor (D-A) probe TQ-1006 (Em = 1006 nm). Compared with its counterpart donor-acceptor-donor (D-A-D) structure TQT-1048 (Em = 1048 nm), TQ-1006 exhibited comparable excellent blood vessels, lymphatic drainage imaging performance, and a higher tumorto-normal tissue (T/N) ratio. An RGD conjugated probe TQ-RGD showed an extra high contrast tumor imaging (T/N ≥ 10), further proving D-A dyes' excellent NIR-II biomedical imaging applications. Overall, the D-A framework provides a promising approach to designing next-generation NIR-II fluorophores.

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“…In recent years, photothermal therapy (PTT), which uses optically absorbing materials to “ablate” cancer cells under near-infrared (NIR) light irradiation, has received huge attention as a potential alternative to traditional cancer therapies. Numerous preclinical animal experiments using diverse NIR light absorbent nanomaterials as potential PT agents (PTAs) have shown the increasing therapeutic potential of PTT. − PTAs should have high absorbance in the NIR region, which is a window of transparency for biological tissues, and be able to effectively convert absorbed NIR optical energy into heat. − NIR-induced PTT (NIR-I, 650–950 nm) has shown outstanding results in both research and clinical trials over the last few years. In comparison with the NIR-I optical window, the NIR-II optical window (1000–1350 nm) offers greater tissue penetration, lower photon absorption and scattering, and maximum permitted exposure (MPE) (1 W/cm 2 ), which makes it more efficient and clinically applicable.…”

Section: Introductionmentioning

confidence: 99%

TLR-7/8 Agonist-Loaded Polypyrrole-Based Theranostic Nanovaccine for Second Near-Infrared Photothermal Immunotherapy of Cancer

Karthikeyan

Yasothamani

Haldorai

et al. 2023

ACS Appl. Nano Mater.

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Functionalized theranostic agents have the potential to be an effective tool for targeting tumor cells with an effective response in cancer imaging and therapy. Particularly, near-infrared (NIR) light is extremely advantageous and can penetrate deeply into biological tissues with minimum attenuation and photodamage to cells. The major impediment to the translation of research into clinical applications is toxicity and long-term body retention. Designing renal clearable and theranostic qualities in a single nanoplatform remains the biggest challenge. Especially, nanomaterials have optical absorption in the second biowindow (NIR-II) with deep penetration and less tissue scattering. Photothermal therapy (PTT), which uses hyperthermia produced by photothermal agents (PTAs) that convert light irradiation to ablate tumors, has received great attention due to its noninvasiveness. Herein, we developed an NIR-II-responsive ultrasmall polypyrrole (PPy)-based theranostic agent conjugated with TAT peptide that has a unique nuclear-targeting property that allows for efficient nuclear-targeted photothermal ablation and immunogenic cell death (ICD). Furthermore, PPy decorated with hyaluronic acid (HA)-loaded toll-like receptor 7/8 immune-activating drug resiquimod (R848), a synthetic agonist for the maturation of dendritic cells. Therefore, the prepared nanocomposite leads to effective tumor cell nuclear ablation, together with a photothermal immune response and renal clearance. This strategy may provide another avenue for highly efficient cancer theranostic nanovaccines.

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A single-molecular ruthenium(ii) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy

Abstract: A novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors was designed and synthesized. Guided by in vivo NIR-II fluorescence imaging, synergistic therapeutic efficacy, intracellular...

Cited by 13 publications

References 31 publications

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

Hypsochromic Shift Donor–Acceptor NIR-II Dye for High-Efficiency Tumor Imaging

TLR-7/8 Agonist-Loaded Polypyrrole-Based Theranostic Nanovaccine for Second Near-Infrared Photothermal Immunotherapy of Cancer

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