A single exposure to an acute stressor has lasting consequences for the hypothalamo–pituitary–adrenal response to stress in free-living birds

Lynn, Sharon E.; Prince, Leslie E.; Phillips, Megan M.

doi:10.1016/j.ygcen.2009.07.018

Cited by 51 publications

(34 citation statements)

References 63 publications

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“…R. Soc. B 283: 20161887 capacity of endocrine axes are plastic traits [16,79,82,83], and so phenotype-fitness correlations for these traits are also subject to environmental bias. Most of the existing studies of selection on endocrine traits use proxies to estimate fitness, such as clutch size, fledging success or annual survival.…”

Section: Further Complications For Estimating Selection From Phenotypmentioning

confidence: 99%

How can we estimate natural selection on endocrine traits? Lessons from evolutionary biology

Bonier¹,

Martin²

2016

Proc. R. Soc. B.

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An evolutionary perspective can enrich almost any endeavour in biology, providing a deeper understanding of the variation we see in nature. To this end, evolutionary endocrinologists seek to describe the fitness consequences of variation in endocrine traits. Much of the recent work in our field, however, follows a flawed approach to the study of how selection shapes endocrine traits. Briefly, this approach relies on among-individual correlations between endocrine phenotypes (often circulating hormone levels) and fitness metrics to estimate selection on those endocrine traits. Adaptive plasticity in both endocrine and fitness-related traits can drive these correlations, generating patterns that do not accurately reflect natural selection. We illustrate why this approach to studying selection on endocrine traits is problematic, referring to work from evolutionary biologists who, decades ago, described this problem as it relates to a variety of other plastic traits. We extend these arguments to evolutionary endocrinology, where the likelihood that this flaw generates bias in estimates of selection is unusually high due to the exceptional responsiveness of hormones to environmental conditions, and their function to induce adaptive life-history responses to environmental variation. We end with a review of productive approaches for investigating the fitness consequences of variation in endocrine traits that we expect will generate exciting advances in our understanding of endocrine system evolution.

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Section: Further Complications For Estimating Selection From Phenotypmentioning

confidence: 99%

How can we estimate natural selection on endocrine traits? Lessons from evolutionary biology

Bonier¹,

Martin²

2016

Proc. R. Soc. B.

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“…They found that repeated experience with this paradigm results in lower corticosterone (CORT) levels than in birds sampled for the first time, probably due to familiarity with the procedure. Similarly, Lynn et al [39] found that a single previous exposure to the capture and handling protocol resulted in attenuated adrenocortical responsiveness in adult eastern bluebirds (Sialia sialia). Our study focused on a qualitatively different type of handling, designed to mimic what a nestling might experience during the collection of routine morphological measurements throughout the nestling period and is more similar to the type of handling that produces permanent, developmental effects on the HPA axis in rats (e.g., [44,45,46]).…”

Section: Introductionmentioning

confidence: 88%

“…Therefore, even if the kestrels did acclimate to the daily handling routine (and we suspect they did), then their failure to dishabituate when faced with the novel stressor violates one of the criteria for hormonal habituation in field studies [17] and suggests that the attenuation of the HPA axis in handled nestlings reflects differences in the underlying physiological mechanisms between the handled and unhandled birds, not habituation. While as few as one previous bout of capture and bleeding may result in habituation to the sampling protocol in nestlings or adults [36,39], our birds were not previously bled, so habituation to the blood sampling protocol itself could not have occurred. Nonetheless, our data do not allow us to reject the possibility that it is the initial step of capturing and handling the birds, and not the subsequent blood sampling and confinement, that elicits a stress response to which the birds could habituate over time.…”

Section: Habituationmentioning

confidence: 99%

The effects of neonatal handling on adrenocortical responsiveness, morphological development and corticosterone binding globulin in nestling American kestrels (Falco sparverius)

Whitman

Breuner

Dufty

2011

General and Comparative Endocrinology

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This is an author-produced, peer-reviewed version of this article. © 2009, Elsevier. Licensed under the Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/). The final, definitive version of this document can be found online at General and Comparative Endocrinology, doi: 10.1016/j.ygcen.2011.03.009 1 NOTICE: This is the author"s version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published in General and Comparative Endocrinology, 2011. DOI: 10.1016/j.ygcen.2011 The AbstractEarly developmental experiences play an important role in development of the adult phenotype. We investigated the effects of neonatal handling on the hypothalamic-pituitaryadrenal axis in a free-living avian species, the American kestrel (Falco sparverius). In the handled group (H), kestrel chicks were handled for 15 min/day from hatching until 26 days of age, after which time blood samples were collected for analysis of adrenal responsiveness and corticosterone binding globulin (CBG) levels. The non-handled control group (NH) was left undisturbed until 26 days of age when blood samples were collected and analyzed as above. Handled and NH kestrels did not differ in body condition index. Both total corticosterone (CORT) and CBG capacity were dampened significantly in H kestrels. However, free CORT did not differ between the two groups. In addition, hormone challenges of corticotropin releasing factor and adrenocorticotropin hormone were compared to saline injections to determine if the pituitary or the adrenal glands, respectively, were rendered more or less sensitive by handling. There was no difference in the responsiveness of H and NH kestrels to either hormone challenge. It is clear from these data that handling had an affect on fledgling phenotypic development, although whether the effects are permanent or ephemeral is unknown.

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“…For the effect of chronic stress on the acute glucocorticoid stress response, there is no general prediction from the literature (Dickens and Romero 2013). The lack of a uniform pattern may be due to large betweenindividual variation (Cockrem and Silverin 2002;Almasi et al 2010;Lynn et al 2010) and the additional interference of life history stage, age, sex and context. Hence there is a need for studies investigating which direct or indirect human activities are reflected in elevated baseline corticosterone, indicative of a disturbance of homeostasis, or an altered glucocorticoid stress response, and whether such changes translate into a reduction of fitness parameters.…”

Section: Introductionmentioning

confidence: 99%

Agricultural land use and human presence around breeding sites increase stress-hormone levels and decrease body mass in barn owl nestlings

et al. 2015

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(b) fitness parameters: growth of the nestlings and breeding performance. Nestlings growing up in intensively cultivated areas showed increased baseline corticosterone levels late in the season and had an increased corticosterone release after a stressful event, while their body mass was decreased. Nestlings experiencing frequent anthropogenic disturbance had elevated baseline corticosterone levels, an increased corticosterone stress response and a lower body mass. Finally, breeding performance was better in structurally more diverse landscapes. In conclusion, anthropogenic disturbance affects offspring quality rather than quantity, whereas agricultural practices affect both life history traits.

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A single exposure to an acute stressor has lasting consequences for the hypothalamo–pituitary–adrenal response to stress in free-living birds

Cited by 51 publications

References 63 publications

How can we estimate natural selection on endocrine traits? Lessons from evolutionary biology

How can we estimate natural selection on endocrine traits? Lessons from evolutionary biology

The effects of neonatal handling on adrenocortical responsiveness, morphological development and corticosterone binding globulin in nestling American kestrels (Falco sparverius)

Agricultural land use and human presence around breeding sites increase stress-hormone levels and decrease body mass in barn owl nestlings

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