A Single Common Stability Indicating Ultra-Performance Liquid Chromatographic Method for Estimation of Impurities in Four Angiotensin Ii Receptor Blockers

Rao, Dantu Durga; Krishna, Galla Vamsi; Reddy, A. Malleswara; Kalyanaraman, L.; Kyas, K.

doi:10.1080/10826076.2011.627615

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 1 shows the LOS spectra profile during the UVC/photolysis treatment. At 0 min, the retention time at 10 min corresponds to LOS initial concentration of the 2.5 mg L −1 (4.6 μM) and also observed smaller peaks at R T of 11.3 e 12 min that could be attributed to impurities or the instability of the LOS solution during the manipulation (Rao et al 2012 ). The authors investigated the stability of antihypertensive drugs and degradation by-products from solutions prepared under laboratory conditions, similarly to the present study.…”

Section: Resultsmentioning

confidence: 98%

Ecotoxicity and genotoxicity assessment of losartan after UV/H2O2 and UVC/photolysis treatments

Adams

Neves

Prola

et al. 2020

Environ Sci Pollut Res

View full text Add to dashboard Cite

Losartan potassium (LOS) is one of the most antihypertensives used in the world, and its presence in environmental matrices can cause impacts to biota. In this study, the ecotoxicity and genotoxicity of LOS was assessed before and after treatment by UVC/photolysis and UV/H 2 O 2 . The photodegradations were carried out at LOS solutions (2.5 mg L −1 ; 4.6 μM) for 30, 60, 90, 120, 240, and 480 min of treatment. For chromatographic analysis, the samples were submitted to solid-phase extraction (SPE) and analyzed by HPLC-DAD. Ecotoxicity bioassays were conducted using Daphnia magna (acute) and Desmodesmus subspicatus (chronic) for all the degradation times. To evaluate the genotoxicity, the comet assay was performed with a D. magna whole organism cell suspension applying the alkaline gel electrophoresis technique. For both process, the degradation rate was over 99% at 30 min, which reduced the acute toxicity of LOS to D. magna . In addition, only the sample treated at 240 min by UV/H 2 O 2 showed significant chronic and acute toxicity. However, the genotoxicity effect was observed for samples treated LOS before treatment and at 480 min by UV/H 2 O 2 . Therefore, even reaching high LOS degradation rates, for both processes, the bioassays demonstrated the importance of ecotoxicological analyses by AOPs treatment. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-020-11420-9.

show abstract

Section: Resultsmentioning

confidence: 98%