A single centre’s experience of managing spheno-orbital meningiomas: lessons for recurrent tumour surgery

Shapey, Jonathan; Jung, Josephine; Barkas, Konstantinos; Gullan, Richard; Barazi, Sinan; Bentley, Robert; Huppa, Christoph; Thomas, Nicholas

doi:10.1007/s00701-019-03977-3

Cited by 21 publications

(23 citation statements)

References 37 publications

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“…However, few reports investigated the efficacy of postoperative radiotherapy for SOMs. Most of the studies reported on small patient cohorts with SOM and postoperative radiotherapy without providing clear conclusions on the role of postoperative radiotherapy (4,17,19,20). Others recommended postoperative radiotherapy in the case of atypical/rapidly progressive tumors (12,13,16,21).…”

Section: Radiotherapymentioning

confidence: 99%

Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

et al. 2021

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ObjectiveSpheno-orbital meningiomas (SOM) are rare intracranial tumors that arise at the sphenoid wing. These tumors can invade important neurovascular structures making radical resection difficult, while residual tumors often lead to recurrence. The purpose of this study was to evaluate prognostic factors influencing the recurrence and progression-free survival (PFS) rates of spheno-orbital meningiomas, with a particular focus on the role of surgery and postoperative radiotherapy.MethodsBetween 2000 and March 2020, 65 cases of spheno-orbital meningioma were included, of which 50 cases underwent surgical treatment alone, and 15 cases underwent resection and radiotherapy. A Kaplan-Meier analysis was performed to provide median point estimates and PFS rates; further, Cox regression analysis was used to identify significant factors associated with treatment.ResultsGross total resection significantly reduced the risk of recurrence (p-value = 0.0062). There was no significant benefit for progression-free survival after postoperative radiotherapy (p-value = 0.42). Additionally, spheno-orbital meningiomas with an invasion of the cavernous sinus and intraconal invasion showed significantly worse PFS compared to other locations (p-value = 0.017).ConclusionThe maximal safe resection remains the most important prognostic factor associated with lower recurrence rates and longer PFS in patients with spheno-orbital meningioma. The invasion of the cavernous sinus and intraconal invasion was an independent factor associated with worse PFS. Patients with postoperative high-precision radiotherapy did not show significantly better PFS due to the small number of patients.

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Section: Radiotherapymentioning

confidence: 99%

Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

et al. 2021

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“…In conclusion, we maintain that a standard or modified mini-orbitozygomatic craniotomy allows the optimum access to larger tumours, particularly those with intradural involvement and those with visual problems, and that good cosmetic outcomes may be achieved when combining this approach with the use of custom-made implants [2].…”

Section: Dear Editormentioning

confidence: 64%

Letter of response to: spheno-orbital meningiomas

et al. 2019

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“…5 Shapey dkk melaporkan sebanyak 38,5% pasien yang dioperasi mengalami perbaikan proptosis. 10 Young dkk melaporkan sebanyak 24% pasien dengan proptosisnya hilang dan 53% pasien mengalami perbaikan proptosis. 11 Di lain pihak, Pace dkk mengatakan 85% pasien mengalami perbaikan secara kosmetik.…”

Section: Pembahasanunclassified

“…Tidak ada perbedaan yang bermakna antara visus pascaoperasi pertama dengan reoperasi. 10 Kompresi saraf optikus yang terjadi dalam jangka waktu yang lama mungkin juga menjadi penyebab rendahnya jumlah subjek dengan peningkatan visus. Lamanya gejala praoperasi mempunyai korelasi negatif dengan visus praoperasi dan semakin rendah perbaikan visus pada pasien dengan gejala lebih dari 6 bulan.…”

Section: Pembahasanunclassified

Evaluasi Tajam Penglihatan Dan Indeks Proptosis Pasien Meningioma Sphenoorbita Pascaoperasi Kraniektomi

Aman

Keswani

Ichwan

et al. 2020

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Pendahuluan: Meningioma sphenoorbita (MSO) adalah massa tumor eksofitik yang menginfiltrasi tulang pada sphenoid ridge, dinding lateral orbita, atap orbita, dan meluas ke fisura orbita superior. Trias klasik dari klinis pasien adalah penonjolan bola mata (proptosis), penurunan ketajaman penglihatan (visus) dan oftalmoplegia. Hasil dari operasi pasien MSO belum pernah dievaluasi sebelumnya, terutama terhadap visus dan proptosis. Tujuan: Mengevaluasi karakteristik klinis pasien meningioma sphenoorbita sebelum dan sesudah operasi. Metode: Penelitian deskriptif dengan desain potong lintang. Subjek adalah pasien MSO yang datang ke Unit Rawat Jalan Bedah Saraf RSUPN Dr. Cipto Mangunkusumo (RSCM) dari Januari 2014 hingga Desember 2015. Semua pasien menjalani operasi kraniektomi, orbitotomi lateral dan reseksi tumor. Ketajaman visus dievaluasi dengan Snell chart dan indeks proptosis pasien dievaluasi sebelum dan sesudah operasi dengan mengukur mata yang proptosis pada CT scan aksial. Hasil: Terdapat 66 pasien yang dievaluasi dalam penelitian ini dan 65 pasien adalah perempuan. Rentang usia 31-64 tahun. Indeks proptosis rata-rata preoperasi adalah 18,27 dan pascaoperasi adalah 16,43. Pengurangan indeks proptosis rata-rata adalah 1,84. Visus pasien pascaoperasi mengalami perbaikan hanya pada 9,7% pasien. Diskusi: Pasien MSO yang dioperasi terdapat pengurangan indeks proptosis tetapi hanya sedikit perbaikan visus. Kata kunci: Indeks proptosis, meningioma sphenoorbita, visus

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A single centre’s experience of managing spheno-orbital meningiomas: lessons for recurrent tumour surgery

Cited by 21 publications

References 37 publications

Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

Letter of response to: spheno-orbital meningiomas

Evaluasi Tajam Penglihatan Dan Indeks Proptosis Pasien Meningioma Sphenoorbita Pascaoperasi Kraniektomi

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