volume 3, issue 1, P119-124 2012
DOI: 10.5155/eurjchem.3.1.119-124.449
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Abstract: A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.Amines Solvent-free Neat condition Aromatic aldehydes Multi component reaction Trimethyl/trie…

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