A simple, solvent and catalyst-free green synthetic protocol for α-amino phosphonates

Abstract

A simple and efficient method for the synthesis of α-amino phosphonates has been developed by using aromatic aldehydes, amines, and trimethyl/triethyl phosphite, under catalyst and solvent free conditions, with the formation of the product in good to excellent yields. This method involves milder reaction conditions, easy work-up, and cleaner reaction profiles, and may have wide spread application in organic synthesis.Amines Solvent-free Neat condition Aromatic aldehydes Multi component reaction Trimethyl/triethyl phosphite

Facile sonochemical heterocyclization of 2,5-dimethoxy tetrahydrofuran with primary amines using sulfonated MWCNTs as a recyclable catalyst in aqueous media

“…The recovered catalyst (0.019 g) was reused in the reaction for four runs. All of the pure products were characterized by comparison of their physical and spectral data with authentic samples (43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53).…”