A simple score for assessing stable chronic obstructive pulmonary disease

Esteban, Cristóbal; Quintana, José M.; Aburto, Myriam; Moraza, Javier; Capelastegui, Alberto

doi:10.1093/qjmed/hcl110

Cited by 49 publications

(46 citation statements)

References 41 publications

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“…5,16 ). Among many dyspnea scales, the mMRC is commonly used for COPD prognostic scales and for daily practice [4][5][6][7][8][9][10][11] . The advantage of the mMRC over other dyspnea scales is its simplicity and the use of solid intervals between scores 18 .…”

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

“…Furthermore exercise capacity tests are risky as they can cause hypoxia. Therefore, most of the recently devised COPD prognostic scales do not include an exercise capacity test [5][6][7][8][9] .…”

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

“…General health condition: General health condition is a component of the HADO score 6,7 . Although we agreed that the general health condition is an indicator of death, we did not include this factor in our scale because reconstruction has not been sufficiently demonstrated for this score.…”

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

“…The orthodox method of building a prognostic scale consists of two steps: the development of a scale using an initial cohort, and the validation of the scale using another patient cohort [4][5][6][7][8][9][10][11] . As the impact of each component varied greatly across studies, probably due to background patient characteristics [4][5][6][7][8][9][10][11] depending on a single development cohort is potentially risky. Furthermore, we can access extensive knowledge about life prognostic factors for COPD from previous studies , which were discussed.…”

Section: Limitationsmentioning

confidence: 99%

“…These scales are based on the following measurements: body mass index (BMI), airflow obstruction, dyspnea, and exercise capacity index (BODE index); age, dyspnea and the airway obstruction index (ADO index); the health, activity, dyspnea, and obstruction score; the Briggs prognostic index; a classification and regression tree; and the incremental shuttle walking test, BMI, airflow obstruction, dyspnea, and exercise capacity index [4][5][6][7][8][9][10][11] . These scales allow us to evaluate the systemic presentation of COPD.…”

Section: Introductionmentioning

confidence: 99%

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Chronic obstructive pulmonary disease prognostic score: A new index

Horita¹,

Koblížek²,

Plutinsky³

et al. 2016

BIOMED PAP

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Background. The evaluation of chronic obstructive pulmonary disease (COPD) has been shifting from spirometry to focus on the patients' overall health. Despite the existence of many COPD prognostic scales, there remains a large gap for improvement, in particular a scale that incorporates the current focus on overall health. Methods. We proposed a new prognostic scale (the COPD Prognostic Score) through discussion among the authors based on published studies. Validation was retrospective, using data from the National Emphysema Treatment Trial. Results. The scores ranged from 0-16, where 16 indicated the poorest prognosis. We assigned 4 points each for forced expiratory volume in one second (%predicted), the modified Medical Research Council dyspnea scale, and age; 2 points for the hemoglobin level; and one point each for decreased activity and respiratory emergency admission in the last two years. The validation cohort included 607 patients and consisted of 388 men (73.9%) and 219 women (36.1%), mean age 67 ± 6 years and an average forced expiratory volume in one second (% predicted) of 27 ± 7%. A one-point increase in the score was associated with increased all-cause death, with a hazard ratio of 1.28 (95%CI: 1.21-1.36. P < 0.001). The areas under the receiver operating characteristic curves for two-year and five-year all-cause death for the new scale were 0.72 and 0.66, respectively. These values were higher than those given by the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index and age, dyspnea, airway obstruction (ADO) index. Conclusion. The preliminary validation for a new COPD prognostic scale: the COPD Prognostic Score was developed with promising results thus far. Above mentioned 16-point score accurately predicted 2-year and 5-year all-cause mortality among subjects who suffered from severe and very severe COPD.

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Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chronic obstructive pulmonary disease prognostic score: A new index

Horita¹,

Koblížek²,

Plutinsky³

et al. 2016

BIOMED PAP

View full text Add to dashboard Cite

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Routine Laboratory Tests can Predict In-hospital Mortality in Acute Exacerbations of COPD

Asiimwe

Brims

Andrews

et al. 2011

Lung

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Chronic obstructive pulmonary disease (COPD) has a rising global incidence and acute exacerbation of COPD (AECOPD) carries a high health-care economic burden. Classification and regression tree (CART) analysis is able to create decision trees to classify risk groups. We analysed routinely collected laboratory data to identify prognostic factors for inpatient mortality with AECOPD from our large district hospital. Data from 5,985 patients with 9,915 admissions for AECOPD over a 7-year period were examined. Randomly allocated training (n = 4,986) or validation (n = 4,929) data sets were developed and CART analysis was used to model the risk of all-cause death during admission. Inpatient mortality was 15.5%, mean age was 71.5 (±11.5) years, 56.2% were male, and mean length of stay was 9.2 (±12.2) days. Of 29 variables used, CART analysis identified three (serum albumin, urea, and arterial pCO(2)) to predict in-hospital mortality in five risk groups, with mortality ranging from 3.0 to 23.4%. C statistic indices were 0.734 and 0.701 on the training and validation sets, respectively, indicating good model performance. The highest-risk group (23.4% mortality) had serum urea >7.35 mmol/l, arterial pCO(2) >6.45 kPa, and normal serum albumin (>36.5 g/l). It is possible to develop clinically useful risk prediction models for mortality using laboratory data from the first 24 h of admission in AECOPD.

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Application of appropriateness criteria for hospitalization in COPD exacerbation

et al. 2013

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The IRYSS-COPD appropriateness study was developed in 16 hospitals belonging to the Spanish National Health Service from June 2008 to September 2010 (n = 2,877). The objectives were to apply a set of explicit criteria for the appropriateness of hospital admission created by the RAND/UCLA methodology to patients evaluated in the emergency department (ED) for exacerbations of COPD. This is a prospective cohort study. We explored the relationship between appropriateness of admission as defined by the explicit criteria and the final decision to admit or discharge. A total of 2,877 patients were included for analysis; of these, 1,747 (60.7 %) were admitted and 1,130 (39.3 %) were discharged from the ED to home. Among patients classified by the explicit criteria as appropriate for hospital admission, 81.3 % were admitted, compared with 64.81 % of those classified as uncertain and 48.65 % of those classified as inappropriate for admission. Severity of exacerbation was the most influencing variable in the decision. Application of our explicit criteria for appropriate hospital admission among a large sample of patients experiencing an exacerbation of COPD in the ED setting suggests that these criteria could be used as the basis for clinical decision-making and health-care assessment.

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A simple score for assessing stable chronic obstructive pulmonary disease

Abstract: The HADO score can be easily obtained in an out-patient clinic, and distinguishes groups of COPD patients by their disease severity. The HADO score is better than FEV(1%) alone for predicting mortality at 3 years.

Cited by 49 publications

References 41 publications

Chronic obstructive pulmonary disease prognostic score: A new index

Chronic obstructive pulmonary disease prognostic score: A new index

Routine Laboratory Tests can Predict In-hospital Mortality in Acute Exacerbations of COPD

Application of appropriateness criteria for hospitalization in COPD exacerbation

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