2016
DOI: 10.1371/journal.pone.0165558
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Abstract: PurposeTo compare a novel spectral-domain optical coherence tomography (SD-OCT) technique with traditional lid transillumination for evaluation of meibomian glands (MGs) and to assess the relation of MG morphologic changes to the glandular atrophy.DesignEvaluation of diagnostic technology.ParticipantsSixty-one patients with obstructive MGD (30 men, 31 women; age [mean ± standard deviation] 45.1 ± 12.1 years), and 75 control subjects (32 men, 43 women; 44.1 ± 12.5 years) were recruited in order to have a balanc… Show more

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Cited by 30 publications
(25 citation statements)
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“…Several authors have confirmed that meibomian glands can be optimally visualized using commercial OCTs and custom-built systems. Moreover, a good agreement between OCT meibography and traditional lid transillumination has been demonstrated by our group (Figure 9) [87]. J. Clin.…”
Section: Meibomian Glandssupporting
confidence: 73%
“…Several authors have confirmed that meibomian glands can be optimally visualized using commercial OCTs and custom-built systems. Moreover, a good agreement between OCT meibography and traditional lid transillumination has been demonstrated by our group (Figure 9) [87]. J. Clin.…”
Section: Meibomian Glandssupporting
confidence: 73%
“…While these results cannot necessarily be extended to the general population, they are useful for understanding the complex relationship that HBC has with the ocular surface in a population where its use is highly prevalent. Second, the main outcome of interest, severe Meibomian gland atrophy, was present in 17 of 202 eyes (8.4%) in this young population compared to 18% [ 15 ] and 43% [ 16 ] reported in older populations whose mean ages were 45 [ 15 ] and 57 [ 16 ] years, respectively. Although it is unclear if this current study accurately represents Meibomian gland atrophy distribution in the general population for this age group, these results are consistent with the expectation that the prevalence of severe Meibomian gland atrophy is higher in older age groups [ 9 , 16 , 26 ].…”
Section: Discussionmentioning
confidence: 81%
“…Sample size estimates were calculated with two formulas [ 12 , 13 ] for the dichotomous outcome and one [ 14 ] for the continuous outcomes, using previously published population estimates for the main outcome severe Meibomian gland atrophy [ 15 , 16 ], and for the secondary outcomes tear lipid layer thickness [ 16 , 17 ], non-invasive tear breakup time [ 17 , 18 ], fluorescein tear breakup time [ 17 19 ], and SPEED score [ 17 , 20 ]. The highest sample size estimate for the main outcome of severe Meibomian gland atrophy, derived from the formula by Peduzzi, et al [ 12 ], and from population estimates of severe Meibomian gland atrophy by Napoli, et al [ 15 ], was 55 subjects in order to detect 3:1 odds of having severe Meibomian gland atrophy with 5% two-sided level of significance and 80% statistical power. The highest estimate among all outcomes was for fluorescein tear breakup time using the formula from Charan, et al [ 14 ] and population estimates from Yeh, et al [ 18 ] suggesting a sample size of 101 subjects to detect a minimum of a five-second difference in tear breakup time with 5% two-sided level of significance and 80% statistical power.…”
Section: Methodsmentioning
confidence: 99%
“…Since then, other instruments based on IR light have been used for this purpose. Recently, Napoli et al [27] propose the usage of an Optical Coherent Tomography (OCT) technique to evaluate Meibomian glands showing its advantages against conventional imaging techniques. In this work, Napoli et al used image processing technique to enhance the contrast and brightness of OCT images (taken at a wavelength of 840 nm) so the microscopic structures of the glands could be highlighted.…”
mentioning
confidence: 99%