A simple method for the trace determination of methanol, ethanol, acetone and pentane in human breath and in the ambient air by preconcentration on solid sorbents followed by gas chromatography

Tian, Qian

doi:10.1016/s0039-9140(97)00073-8

Cited by 62 publications

(25 citation statements)

References 21 publications

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“…Pre-concentration on solid sorbents followed by thermal desorption (TD) is the most frequent method for the analysis of VOCs in breath samples [9][10][11][12][13]16,[19][20][21][22][23][24][25][26][27][28][43][44][45]47,55,62,75,[81][82][83][84][85]95,96]. Sorbent traps present the advantages that they can be prepared on a micro-scale and coupled on-line with a GC system to allow near real-time measurements [97][98][99][100][101], and the sorbent configuration can be easily changed to adapt to different compounds.…”

Section: Concentration On Solid Sorbentsmentioning

confidence: 99%

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Analytical challenges in breath analysis and its application to exposure monitoring

Alonso

Sánchez

2013

TrAC Trends in Analytical Chemistry

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There is an increasing interest in the use of breath analysis for monitoring human physiology and exposure to toxic substances or environmental pollutants.This review focuses on the current status of the sampling procedures, collection devices and sample-enrichment methodologies used for exhaled breath-vapor analysis. We discuss the different parameters affecting each of the above steps, taking into account the requirements for breath analysis in exposure assessments and the need to analyze target compounds at sub-ppbv levels.Finally, we summarize the practical applications of exposure analysis in the past two decades.

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Section: Concentration On Solid Sorbentsmentioning

confidence: 99%

“…However, the wide range of VOCs present in breath results in no single sorbent being capable of adsorbing all the compounds present in breath samples, so a multicomponent sorbent is necessary to complete screening and determination [25,44,64,[95][96][97]100,101].…”

Section: Concentration On Solid Sorbentsmentioning

confidence: 99%

Analytical challenges in breath analysis and its application to exposure monitoring

Alonso

Sánchez

2013

TrAC Trends in Analytical Chemistry

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“…The main advantages of NTD are solvent-free like the SPME, simple and fast sampling and short analysis times than most existing methods. 2,11 The drawbacks of NTD are relatively low sampling capacity, rapid breakthrough of the trap, possible dispersion of the elution zones of the analytes, 11 and the poor sampling flow reproducibility from needle to needle. 12 Jinno and his co-worker developed a fiber-packed needle 13 and an in-needle extraction device packed a copolymer of methacrylic acid and ethylene glycol dimethacrylate.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of In-needle Microextraction Device Using Nichrome Wire Coated with Poly(ethylene glycol) and Poly(dimethylsiloxane) for Determination of Volatile Compounds in Lavender Oils

Lee¹,

Lee

2014

Bulletin of the Korean Chemical Society

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A new needle-based device for headspace wire coated in-needle microextraction (HS-WC-INME) was fabricated using a nichrome wire coated with poly(ethylene glycol) (PEG) and poly(dimethylsiloxane) (PDMS) mixture. The proposed needle device was applied for the determination of volatile compounds in lavender and lavandin essential oils by gas chromatography. Fundamental parameters such as needle design, conditions of extraction and desorption were optimized along with the validation of the extraction and desorption efficiency. The optimal conditions were 30 min extraction at 50 o C and 2 min desorption at 240 o C. The calibration curves showed good linearity with the suitable values of the coefficients of determination (r 2 ) greater than 0.99. The limits of detection for linalyl acetate, -caryophyllene, linalool and (+)-limonene were 7.15, 9.04, 10.79 and 22.26 ng, respectively. Analytical recoveries were acceptable in the test samples, varying from 86.7% to 108.0%. The values of relative standard deviations for run to run showed range less than 0.9% while 3.9% through 7.2% for needle to needle. The proposed PEG-PDMS coating could be more suitable than PDMS coating to extract particular polar groups such as alcohols.

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“…Methanol is ubiquitously present in the human body and it also appears in human blood and breath [1]. It is produced by bacterial fermentation or by decomposition of pectins contained in fruits [2].…”

Section: Introductionmentioning

confidence: 99%

A Survey on the Methanol Content of Home Distilled Alcoholic Beverages in Transylvania (Romania)

Croitoru

Elena

Fülöp

et al. 2013

Acta Medica Marisiensis

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Objective: Methanol appears in relatively high concentrations in alcoholic beverages obtained from fermented fruits distillates. These products are traditionally home made in many regions in Romania and other EU countries. The chronic use of products with high methanol concentration can be considered a health risk. The purpose of this work was to measure methanol concentration in a Romanian region where brandy-type alcoholic products are made from different fruits (plum, apple, pear, grapes), and to observe if there is a type of product that contains more methanol than the others. Methods: The content of methanol in the tested alcoholic beverages was determined using a gas chromatographic method. Results: Only 18% of the tested 56 samples met UE regulation regarding methanol content of alcoholic beverages (0.4% in alcoholic drinks containing 40% ethanol). The highest concentration of 2.39% was found in a plum brandy. Plum brandies contained signifi cantly higher amounts of methanol than brandies made from other fruits (0.91 vs 0.52%, p = 0.01). Conclusions: Home distilled alcoholic beverages obtained from fruits are a health threat due to their high methanol content. Strict regulations and tests should be introduced for such products.

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A simple method for the trace determination of methanol, ethanol, acetone and pentane in human breath and in the ambient air by preconcentration on solid sorbents followed by gas chromatography

Cited by 62 publications

References 21 publications

Analytical challenges in breath analysis and its application to exposure monitoring

Analytical challenges in breath analysis and its application to exposure monitoring

Fabrication of In-needle Microextraction Device Using Nichrome Wire Coated with Poly(ethylene glycol) and Poly(dimethylsiloxane) for Determination of Volatile Compounds in Lavender Oils

A Survey on the Methanol Content of Home Distilled Alcoholic Beverages in Transylvania (Romania)

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