A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health

Leung, Yuet-Kin

doi:10.3390/ijms24129790

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Understanding these interactions is essential for elucidating the etiology of EC and formulating holistic approaches for prevention and intervention. PFAS is a potent endocrine disruptor, and various studies allude to its devastating effect in interacting with hormone receptors and pathways in the body, potentially leading to hormonal dysregulation [ 230 , 231 ]. A recent study found a strong correlation between several PFAS and some hormones such as DHEAS, thyroid, parathyroid, and thyroid hormones in both girls and boys [ 232 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Ayodele,

Obeng-Gyasi

2024

Cancers

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This exploratory narrative review paper delves into the intricate interplay between per- and polyfluoroalkyl substances (PFAS) exposure, sociodemographic factors, and the influence of stressors in the context of endometrial cancer. PFAS, ubiquitous environmental contaminants notorious for their persistence in the ecosystem, have garnered attention for their potential to disrupt endocrine systems and provoke immune responses. We comprehensively examine the various sources of PFAS exposure, encompassing household items, water, air, and soil, thus shedding light on the multifaceted routes through which individuals encounter these compounds. Furthermore, we explore the influence of sociodemographic factors, such as income, education, occupation, ethnicity/race, and geographical location and their relationship to endometrial cancer risk. We also investigated the role of stress on PFAS exposure and endometrial cancer risk. The results revealed a significant impact of sociodemographic factors on both PFAS levels and endometrial cancer risk. Stress emerged as a notable contributing factor influencing PFAS exposure and the development of endometrial cancer, further emphasizing the importance of stress management practices for overall well-being. By synthesizing evidence from diverse fields, this review underscores the need for interdisciplinary research and targeted interventions to comprehensively address the complex relationship between PFAS, sociodemographic factors, stressors, and endometrial cancer.

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Section: Resultsmentioning

confidence: 99%

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Ayodele,

Obeng-Gyasi

2024

Cancers

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“…Endocrine disruptors chemicals (EDCs) are a group of substances with endocrine hormone effects, most of which are artificially synthesized chemicals, such as bisphenol A, phthalates (PAEs), insecticides, polychlorinated biphenyls, and more (15). These substances can enter the human body through ingestion in the digestive tract, inhalation in the respiratory tract, and skin contact, resulting in a variety of adverse effects, which are mainly characterized by endocrine disruption, hormone function disruption, and reproductive organ developmental disorders, and in severe cases, can induce cancer (16,17). Evidence suggests that EDCs may be associated with a significant increase in the prevalence of metabolic diseases such as obesity (18).…”

Section: Introductionmentioning

confidence: 99%

Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016

Zhang,

Gu,

Zhai

et al. 2024

Front. Endocrinol.

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BackgroundObesity and metabolic syndrome pose significant health challenges in the United States (US), with connections to disruptions in sex hormone regulation. The increasing prevalence of obesity and metabolic syndrome might be associated with exposure to phthalates (PAEs). Further exploration of the impact of PAEs on obesity is crucial, particularly from a sex hormone perspective.MethodsA total of 7780 adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 were included in the study. Principal component analysis (PCA) coupled with multinomial logistic regression was employed to elucidate the association between urinary PAEs metabolite concentrations and the likelihood of obesity. Weighted quartiles sum (WQS) regression was utilized to consolidate the impact of mixed PAEs exposure on sex hormone levels (total testosterone (TT), estradiol and sex hormone-binding globulin (SHBG)). We also delved into machine learning models to accurately discern obesity status and identify the key variables contributing most to these models.ResultsPrincipal Component 1 (PC1), characterized by mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) as major contributors, exhibited a negative association with obesity. Conversely, PC2, with monocarboxyononyl phthalate (MCNP), monocarboxyoctyl phthalate (MCOP), and mono(3-carboxypropyl) phthalate (MCPP) as major contributors, showed a positive association with obesity. Mixed exposure to PAEs was associated with decreased TT levels and increased estradiol and SHBG. During the exploration of the interrelations among obesity, sex hormones, and PAEs, models based on Random Forest (RF) and eXtreme Gradient Boosting (XGBoost) algorithms demonstrated the best classification efficacy. In both models, sex hormones exhibited the highest variable importance, and certain phthalate metabolites made significant contributions to the model’s performance.ConclusionsIndividuals with obesity exhibit lower levels of TT and SHBG, accompanied by elevated estradiol levels. Exposure to PAEs disrupts sex hormone levels, contributing to an increased risk of obesity in US adults. In the exploration of the interrelationships among these three factors, the RF and XGBoost algorithm models demonstrated superior performance, with sex hormones displaying higher variable importance.

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Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations

Cortes-Ramirez,

Ho,

Leung

2024

IJMS

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A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health

Abstract: Endocrine-disrupting chemicals (EDCs) are chemicals, either natural or synthetic, that can interfere with the production, distribution, function, metabolism, or excretion of hormones in our body [...]

Cited by 3 publications

References 9 publications

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016

Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations

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