A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of universal infant hepatitis B vaccination

Zhang, Li; Xu, Aiqiang; Yan, Bingyu; Song, Lizhi; Li, Manshi; Xiao, Zhengguo; Xu, Qi; Li, Liming

doi:10.1016/j.ijid.2009.08.005

Cited by 31 publications

(32 citation statements)

References 15 publications

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“…45 In Taiwan, where routine infant HepB vaccination commenced in 1984, there has been a 75% decrease in the incidence of HCC among children. 18 These data are consistent with those of many studies in China, 28,46,47 which have shown the HBsAg prevalence has declined significantly since the introduction of the HepB vaccination. The national serological survey in 2006 shows that for population aged 1-59 years, the HBsAg carrier rate of person aged 0-59 y has decreased from 9.75% in 1992 to 7.18% in 2006 and for children <5 y is now only 1.0%.…”

Section: Discussionsupporting

confidence: 88%

24 year outcomes of hepatitis B vaccination in Hangzhou, China

Xu²,

Wang³

et al. 2015

Human Vaccines & Immunotherapeutics

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To evaluate the impact of the universal infant HepB vaccination program on hepatitis B virus infection in Hangzhou, China. Hepatitis B incidences and HepB vaccination rates of Hangzhou from 1990 to 2003 were acquired from the historical paper-documents, while which were derived from China Information System for Diseases Control and , P < 0.001). Significant association was found between incidence of hepatitis B and HepB vaccination rate (r D 0 .946, x 2 D 11.813, P for trend D 0.001). A total of 5605 participants aged 0-59 y included in this serological survey. The prevalence of HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe were 6.19%, 45.83%, 57.25%, 0.62%, and 4.37%, respectively. Hangzhou has successfully integrated the HepB into routine immunization programs and this has had a significant impact on decreasing the incidence of hepatitis B infection.

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Section: Discussionsupporting

confidence: 88%

24 year outcomes of hepatitis B vaccination in Hangzhou, China

Xu²,

Wang³

et al. 2015

Human Vaccines & Immunotherapeutics

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“…However, the prevalence of HBsAg among children 5–9 years of age in Wuwei City was significantly higher than rates reported from a national survey in 2006 for children of a similar age, possibly due to the lower vaccine coverage rates at birth between 2001–2005 in western China than in eastern China[6], [17], which resulted in increased HBV infection risks[7], [18]. Having household contact with HBV carriers has been considered to be important risk factors for hepatitis B infection, which included mother-to-child transmission and other members transmission.…”

Section: Discussionmentioning

confidence: 77%

A Population-Based Study Examining Hepatitis B Virus Infection and Immunization Rates in Northwest China

Wang²,

Shao

et al. 2014

PLoS ONE

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Background and AimCurrent baseline data regarding the prevalence of hepatitis B virus (HBV) infections and the immune status in hyperendemic areas is necessary in evaluating the effectiveness of ongoing HBV prevention and control programs in northwest China. This study aims to determine the prevalence of chronic HBV infections, past exposure rates, and immune response profiles in Wuwei City, northwest China in 2010.MethodsCross-sectional household survey representative of the Wuwei City population. 28,579 participants were interviewed in the seroepidemiological survey ≥1 year of age. House to house screening was conducted using a standard questionnaire. All serum samples were screened by enzyme-linked immunoassays for the presence of hepatitis B surface antigen, antibodies against HBV surface antigen, and antibodies to the hepatitis B core antigen.ResultsAmong individuals ≥1 year of age, 7.2% (95%CI: 6.3–8.1%) had chronic HBV infections, 43.9% (CI: 40.4–47.4%) had been exposed to HBV, and 23.49% (CI: 21.6–25.3%) had vaccine-induced immunity. Multi-factor weighted logistic regression analysis showed that having household contact with HBV carriers (OR = 2.6, 95%CI: 2.3–3.0) and beauty treatments in public places (OR = 1.2, 95%CI: 1.1–1.3) were the risk factors of HBV infection in whole population. Having household contact with HBV carriers (OR = 3.8, 95% CI: 2.2–6.5) and lack of hepatitis vaccination (OR = 2.0, 95% CI: 1.4–3.3) were the risk factors for HBV infection in children aged 1–14 years.ConclusionsHepatitis B infection remains a serious public health problem in northwest China. Having household contact with HBV carriers and beauty treatments in public places represented HBV infection risk factors. Hepatitis B vaccine immunization strategies need further improvement, particularly by targeting the immunization of rural migrant workers.

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“…The prevalence of anti‐HBs was higher in fully immunized children (63.2–74.3%) than non‐immunized children (21.1–34.8%) . A recent study on the infants immunized with plasma‐derived HBV vaccine showed that although the anti‐HBs positive rate and its titer decreased with time, the average HBV carrier rate of 1.6% did not increase during the 15 years after vaccination . These data indicate that HBV vaccination not only reduces the HBsAg prevalence in early years but also possesses long‐term immunity against HBV infection.…”

Section: Epidemiology Of Chronic Hbv Infection In Chinamentioning

confidence: 90%

“…With the increasing coverage of HBV vaccination in infants, the HBsAg carrier rate in the vaccinated group (1.1%) has dramatically declined as compared with control group (15.8%), giving a protective efficacy of 93.0% (95% confidence interval [CI]: 92.1–94.0%) . The prevalence of anti‐HBs was higher in fully immunized children (63.2–74.3%) than non‐immunized children (21.1–34.8%) .…”

Section: Epidemiology Of Chronic Hbv Infection In Chinamentioning

confidence: 99%

Update on epidemiology of hepatitis B and C in China

Cui

Jia

2013

J of Gastro and Hepatol

277

248

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A high rate of chronic hepatitis B virus (HBV) infection in China is mainly caused by perinatal or early childhood transmission. Administration of universal HBV vaccination in infants has led to a dramatic decrease in HBV epidemiology, with hepatitis B surface antigen (HBsAg) prevalence declining from 9.75% in 1992 to 7.18% in 2006. The major HBV genotypes are B and C, with B being more prevalent in the southern part and C more prevalent in the northern part of China. A national survey carried out in 1992 showed that the hepatitis C virus (HCV) infection rate was 3.20% in general population in China. After implementation of mandatory HCV screening for blood transfusion and other precautions to prevent blood-borne disease since 1993, the new cases of HCV infection associated with blood or blood product has become very rare. Although the anti-HCV prevalence would be much higher in high-risk groups, a survey carried in 2006 showed that the anti-HCV prevalence rate was only 0.43% in general population. This sharp decline in HCV infection rate was mainly due to stringent administration and monitoring of blood donors and blood products, but may also be related to the remarkably improved specificity of anti-HCV test. The predominant HCV genotype in China is genotype 1b (60-70%), and the host interleukin-28b rs12979860 CC genotype is very frequent in Chinese population (over 80%).Chronic infection of hepatitis B virus (HBV) or hepatitis C virus (HCV) poses serious public health problems because of the high prevalence rates in many parts of the world and adverse long-term clinical outcomes, including premature deaths from hepatic decompensation, cirrhosis, and hepatocellular carcinoma (HCC). This is particularly true in China, where the prevalence rates of HBV and HCV infection were considerably high. Fortunately, thanks to the universal HBV vaccination program in infants and mandatory HCV screening in blood donors, and other precautions to prevent blood-borne diseases in health-care settings, the landscape of HBV and HCV epidemiology infection has changed greatly. In this short review, we will provide an update on epidemiology of HBV and HCV infection in mainland China.

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A significant reduction in hepatitis B virus infection among the children of Shandong Province, China: the effect of 15 years of universal infant hepatitis B vaccination

Abstract: Universal hepatitis B vaccination in infants can result in a 90.47% reduction in hepatitis B infection in children aged 1-14 years.

Cited by 31 publications

References 15 publications

24 year outcomes of hepatitis B vaccination in Hangzhou, China

24 year outcomes of hepatitis B vaccination in Hangzhou, China

A Population-Based Study Examining Hepatitis B Virus Infection and Immunization Rates in Northwest China

Update on epidemiology of hepatitis B and C in China

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