A Serum Protein–Based Algorithm for the Detection of Alzheimer Disease

Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology

“…Among which FGA, FGB, FGG, and VMF were involved in platelet activation. Consistent with our findings, VWF was abnormally high in patients with AD in a previous study [23]. Elevated fibrinogen levels have been reported to be associated with increased risk for AD and dementia [26, 29].…”

Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology

“…Among which FGA, FGB, FGG, and VMF were involved in platelet activation. Consistent with our findings, VWF was abnormally high in patients with AD in a previous study [23]. Elevated fibrinogen levels have been reported to be associated with increased risk for AD and dementia [26, 29].…”

PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer’s Disease

“…In addition to the three proteins investigated in this study, our approach provided a comprehensive list of DEPs in MCI and AD, thus extensively extending the current list of candidate biomarkers identified by conventional small-scale approaches. Our data also confirmed a previously reported list of DEPs in AD serum: 1) alpha-2-macroglobulin (upregulated in AD) [51,52], 2) TTR (downregulated in AD) [14], and 3) C3 and APOC2 (downregulated in AD) [25]. The list of proteins provided by our study is expected to serve as a comprehensive resource for the study of MCI and AD.…”

Serum-based Protein Profiles of Alzheimer’s Disease and Mild Cognitive Impairment in Elderly Hispanics

“…In agreement with these results, in a previous study we reported that the cytokine IL-18, one of the key mediators of inflammation and immune response, was decreased in AD subjects relative to controls in a mostly non-Hispanic white cohort [17]. Neuroinflammation has been shown to play a role in AD pathogenesis [54], and we expected proinflammatory molecules to be elevated in AD subjects.…”

Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology

“…Among which FGA, FGB, FGG, and VMF were involved in platelet activation. Consistent with our findings, VWF was abnormally high in patients with AD in a previous study [23]. Elevated fibrinogen levels have been reported to be associated with increased risk for AD and dementia [26, 29].…”

PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer’s Disease

“…In addition to the three proteins investigated in this study, our approach provided a comprehensive list of DEPs in MCI and AD, thus extensively extending the current list of candidate biomarkers identified by conventional small-scale approaches. Our data also confirmed a previously reported list of DEPs in AD serum: 1) alpha-2-macroglobulin (upregulated in AD) [51,52], 2) TTR (downregulated in AD) [14], and 3) C3 and APOC2 (downregulated in AD) [25]. The list of proteins provided by our study is expected to serve as a comprehensive resource for the study of MCI and AD.…”

Serum-based Protein Profiles of Alzheimer’s Disease and Mild Cognitive Impairment in Elderly Hispanics

“…In agreement with these results, in a previous study we reported that the cytokine IL-18, one of the key mediators of inflammation and immune response, was decreased in AD subjects relative to controls in a mostly non-Hispanic white cohort [17]. Neuroinflammation has been shown to play a role in AD pathogenesis [54], and we expected proinflammatory molecules to be elevated in AD subjects.…”

Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology

“…Among which FGA, FGB, FGG, and VMF were involved in platelet activation. Consistent with our findings, VWF was abnormally high in patients with AD in a previous study [23]. Elevated fibrinogen levels have been reported to be associated with increased risk for AD and dementia [26, 29].…”

PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer’s Disease

“…In addition to the three proteins investigated in this study, our approach provided a comprehensive list of DEPs in MCI and AD, thus extensively extending the current list of candidate biomarkers identified by conventional small-scale approaches. Our data also confirmed a previously reported list of DEPs in AD serum: 1) alpha-2-macroglobulin (upregulated in AD) [51,52], 2) TTR (downregulated in AD) [14], and 3) C3 and APOC2 (downregulated in AD) [25]. The list of proteins provided by our study is expected to serve as a comprehensive resource for the study of MCI and AD.…”

Serum-based Protein Profiles of Alzheimer’s Disease and Mild Cognitive Impairment in Elderly Hispanics

“…In agreement with these results, in a previous study we reported that the cytokine IL-18, one of the key mediators of inflammation and immune response, was decreased in AD subjects relative to controls in a mostly non-Hispanic white cohort [17]. Neuroinflammation has been shown to play a role in AD pathogenesis [54], and we expected proinflammatory molecules to be elevated in AD subjects.…”