A SERS pH sensor for highly alkaline conditions and its application for pH sensing in aerosol droplets

Liu, Boyu; Huang, Yuting; Zheng, Wenxu; Wang, Dongmei; Fan, Meikun

doi:10.1039/d2ay00387b

Cited by 3 publications

(1 citation statement)

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“…As a result, scientists still extensively used indirect approaches to retrieve aerosol pH, , such as thermodynamic models including E-AIM and ISORROPIA-II, which require well-defined compositions of the aerosols and precursors. Recently, many advancements are achieved in direct measurement of aerosol pH, which can be loosely categorized into two types, one type employs the thermodynamic equilibrium states within aerosols − and the other type utilizes various tracers. − Here, we use a ratiometric Raman spectroscopy method to measure the equilibrium concentration ratio of sulfate (SO 4 2– ) and bisulfate (HSO 4 – ) in aerosols and then retrieve the pH. To avoid the variation in compartments of different phases, the pH measurements are conducted at the RH values just above the SRHs.…”

Section: Resultsmentioning

confidence: 99%

Liquid–Liquid Phase Separation in Single Suspended Aerosol Microdroplets

Tong,

2023

Anal. Chem.

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Liquid−liquid phase separation (LLPS) is ubiquitous in ambient aerosols. This specific morphology exerts substantial impacts on the physicochemical properties and atmospheric processes of aerosols, particularly on the gas−particle mass transfer, the interfacial heterogeneous reaction, and the surface albedo. Although there are many studies on the LLPS of aerosols, a clear picture of LLPS in individual aerosols is scarce due to the experimental difficulties of trapping a single particle and mimicking the suspended state of real aerosols. Here, we investigate the phase separation in individual contactless microdroplets by a self-constructed laser tweezer/Raman spectroscopy system. The dynamic transformation of the morphology of optically trapped droplets over the course of humidity cycles is detected by the time-resolved cavity-enhanced Raman spectra. The impacts of pH and inorganic components on LLPS in aerosols are discussed. The results show that the increasing acidity can enhance the miscibility between the hydrophilic and hydrophobic phases and decrease the separation relative humidity of aerosols. Moreover, the inorganic components also have various impacts on the aerosol phase state, whose influence depends on their different salting-out capabilities. It brings possible implications on the morphology of actual atmospheric particles, particularly for those dominated by internal mixtures of inorganic and organic components.

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Section: Resultsmentioning

confidence: 99%

Liquid–Liquid Phase Separation in Single Suspended Aerosol Microdroplets

Tong,

2023

Anal. Chem.

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A Ratiometric SERS Probe for Imaging the Macrophage Phenotypes in Live Mice with Epilepsy and Brain Tumor

Duan

Jiang

Sui

et al. 2023

Adv Healthcare Materials

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Macrophage performs multiple functions such as pathogen phagocytosis, antigen presentation and tissue remodeling by polarizing toward a spectrum of phenotypes. Dynamic imaging of macrophage phenotypes is critical for evaluating disease progression and the therapeutic response of drug candidates. However, current technologies cannot identify macrophage phenotypes in vivo. Here, we develop a surface‐enhanced Raman scattering (SERS) nanoprobe, AH1, which enables the accurate determination of physiological pH with high sensitivity and tissue penetration depth through ratiometric Raman signals. Due to the phenotype‐dependent metabolic reprogramming, AH1 can effectively identify macrophage subpopulations by measuring the acidity levels in phagosomes. After intravenous administration, AH1 not only visualizes the spatial distribution of macrophage phenotypes in brain tumors and epileptic regions of mouse models, but also reveals the repolarization of macrophages in brain lesions after drug intervention. This work provides a new tool for dynamically monitoring the disease‐associated immune microenvironment and evaluating the efficacy of immune‐therapeutics in vivo.This article is protected by copyright. All rights reserved

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A novel ratiometric fluorescent sensor from modified coumarin-grafted cellulose for precise pH detection in strongly alkaline conditions

Huang,

Wang,

Zhou

et al. 2024

International Journal of Biological Macromolecules

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A SERS pH sensor for highly alkaline conditions and its application for pH sensing in aerosol droplets

Abstract: Surface-Enhanced Raman Scattering (SERS) has been widely used in pH sensing. However, SERS sensors capable of stably analysing pH in high alkaline conditions are still scarce. In this work, a...

Cited by 3 publications

References 46 publications

Liquid–Liquid Phase Separation in Single Suspended Aerosol Microdroplets

Liquid–Liquid Phase Separation in Single Suspended Aerosol Microdroplets

A Ratiometric SERS Probe for Imaging the Macrophage Phenotypes in Live Mice with Epilepsy and Brain Tumor

A novel ratiometric fluorescent sensor from modified coumarin-grafted cellulose for precise pH detection in strongly alkaline conditions

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