2005
DOI: 10.1007/s00280-005-0097-1 View full text |Buy / Rent full text
|
|

Abstract: Cancers of epithelial origin are responsible for the majority of cancer-related deaths in the USA. Unfortunately, although chemotherapy and/or radiation therapy can sometimes shrink tumors, metastatic cancers of epithelial origin are essentially incurable. It is clear that new approaches are needed to treat these diseases. Although cancer cell lines provide invaluable information, their biological properties often differ in crucial ways from de novo cancer cells. Our laboratory has developed a novel mouse mode… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
3
2
1
36
0
1

Year Published

2007
2007
2015
2015

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

1
36
0
1
Order By: Relevance
“…In addition to flawed regulation of the selfrenewal pathways, the number of cells within a tumor that have the ability to self-renew is constantly expanding, resulting in a continuous expansion of tumorigenic cancer cells (8). Thus, the identification of mechanisms in which cancer cells regenerate through self-renewal is critical to our understanding of tumorigenesis (9). A number of developmental signaling pathways, such as Wnt, Notch, and Hedgehog, have been observed to play pivotal roles in governing both self-renewal and the process of malignant transformation (10,11).…”
Section: Introductionmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…In addition to flawed regulation of the selfrenewal pathways, the number of cells within a tumor that have the ability to self-renew is constantly expanding, resulting in a continuous expansion of tumorigenic cancer cells (8). Thus, the identification of mechanisms in which cancer cells regenerate through self-renewal is critical to our understanding of tumorigenesis (9). A number of developmental signaling pathways, such as Wnt, Notch, and Hedgehog, have been observed to play pivotal roles in governing both self-renewal and the process of malignant transformation (10,11).…”
Section: Introductionmentioning
“…This subpopulation is now widely termed as cancer stem cells (CSCs), also named tumor-initiating cells (T-IC). The exist of CSCs within a tumor was also supported by in vitro ''clonogenic assays'' that showed subpopulations of tumor cells (with increased proliferative capacity) using cells isolated from tumor specimens, as well as by in vivo self-renewal assays that indicated only a small specific subset of cancer cell population had tumorigenic potential when injected into immunodeficient mice 13,14 .…”
Section: The Definition Of Cancer Stem Cellsmentioning
“…Under the cancer stem cell model, it has been noted that present therapy is not effect to target cancer stem cells. Xenograft assay seems to be useful to measure for both proliferation and cancer stem cells self-renewal (Clarke, 2005). Cancer stem cell shares many properties of the normal stem cell.…”
Section: Cancer Stem Cellsmentioning
“…Li and Neaves (2006) recently propose a hypothesis that cancer stem cells may also arise from a microenvironment (or niche) with dominant growth promoting signaling rather than growth-inhibiting signal. Although cancer cell lines provide invaluable information, their biological properties often differ in crucial ways from de novo cancer cells (Clarke, 2005).…”
Section: Cancer Stem Cellsmentioning