A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cellular influx for photodynamic cancer therapy

“…GC is a highly water-soluble, biocompatible, and biodegradable polymer, which has been broadly applied in drug delivery [60][61][62][63] due to its ease of chemical modification (via amine groups) and excellent drug-loading capacity. Besides, GC is positively charged at physiological pH and serves as an excellent choice for cell surface modification [50,64].…”

Targeted therapy for cancer using pH-responsive nanocarrier systems

“…This system was destabilized due to the protonation of DEAP. At physiological pH, the nanogel exhibited self-assembly, and when the pH decreased to tumor extracellular pH (pH 6.8), the nanogel was destabilized due to the protonation of DEAP and accelerated DOX release from nanogels (Oh et al, 2010).…”

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

“…This system was destabilized due to the protonation of DEAP. At physiological pH, the nanogel exhibited selfassembly, and when the pH decreased to tumor extracellular pH (pH 6.8), the nanogel was destabilized due to the protonation of DEAP and accelerated DOX release from nanogels [29]. Chitosan-grafted PNIPAAm can offer the improvement of biodegradability and potential of pHresponsive hydrogel [88].…”

“…Recently, the prevalence of drug-drug interactions in cancer patients treated with oral anticancer drugs is reported which is alarming in the sense that conventional drug delivery system (both oral and intravenous) is dangerous to patients [12,29]. As an alternative strategy to circumvent MDR, by incorporating drugs to nanocarriers can be taken up by cells through an endocytic pathway and escape the effect of Pgp efflux pumps due to their passive accumulation in tumor tissues with leaky vasculature through the EPR effect [25].…”