2014
DOI: 10.1371/journal.pone.0097598
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Abstract: Fish consumption is considered health beneficial as it decreases cardiovascular disease (CVD)-risk through effects on plasma lipids and inflammation. We investigated a salmon protein hydrolysate (SPH) that is hypothesized to influence lipid metabolism and to have anti-atherosclerotic and anti-inflammatory properties. 24 female apolipoprotein (apo) E−/− mice were divided into two groups and fed a high-fat diet with or without 5% (w/w) SPH for 12 weeks. The atherosclerotic plaque area in aortic sinus and arch, p… Show more

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Cited by 42 publications
(55 citation statements)
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“…Whereas krill oil showed an important effect on cholesterol levels and metabolism that could explain its atheroprotective activity, krill proteins did not seem to affect plasma lipid levels/metabolism, nor cytokine plasma levels and aortic expression of inflammatory markers, as conversely reported for a salmon protein hydrolysate . A hypothesis that could explain the beneficial effect of krill proteins on atherosclerosis observed in the present study may reside in the higher arginine content of this dietary component compared with casein.…”
Section: Discussioncontrasting
confidence: 48%
See 1 more Smart Citation
“…Whereas krill oil showed an important effect on cholesterol levels and metabolism that could explain its atheroprotective activity, krill proteins did not seem to affect plasma lipid levels/metabolism, nor cytokine plasma levels and aortic expression of inflammatory markers, as conversely reported for a salmon protein hydrolysate . A hypothesis that could explain the beneficial effect of krill proteins on atherosclerosis observed in the present study may reside in the higher arginine content of this dietary component compared with casein.…”
Section: Discussioncontrasting
confidence: 48%
“…ApoE possesses relevant immunomodulatory properties, including the capacity to suppress lymphocyte proliferation, immunoglobulin synthesis, and neutrophil activation . As a consequence, apoE deletion is associated with increased T lymphocyte proliferation, cytokine synthesis and adhesion molecule expression, so that apoEKO mice have been used to evaluate the effect of dietary or pharmacological treatments on inflammation . Based on these data, we cannot exclude that in the present study the modulatory effects of n‐3 PUFAs on these parameters have been counterbalanced by the pro‐inflammatory milieu driven by apoE deficiency, resulting in a neutral effect of n‐3 PUFAs on inflammation.…”
Section: Discussionmentioning
confidence: 86%
“…Relatively to fatty acid profile of meagre liver analyzed in the present study, results are expressed in Table . The fatty acid profile modulation is faster observed in the liver, since this organ is the main site of lipid metabolism, as well as of its regulation and therefore major changes in FA composition were expected in this tissue with the different diets supplementation. The fatty acid composition in the meagre liver was affected by oil source ( p < 0.0001), mainly oleic acid (OA; C18:1 n 9), LA, ALA, ARA, EPA and DHA (Table ).…”
Section: Resultsmentioning
confidence: 99%
“…At the end of the dietary treatment, mice were anaesthetized with 2% isoflurane (Parolini et al, ), and blood was collected from a subset of mice, after 5‐hr fast, for plasma lipid quantification, as described (Busnelli et al, ). In a second subset of unfasted mice, blood was collected for FACS (0.1% w/v EDTA) from the retroorbital plexus.…”
Section: Methodsmentioning
confidence: 99%