A safety investigation into topical effects of naproxen sodium on nasal epithelial cells and potential toxicity in local application

Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts

“…Regarding pharmacological safety, NSAIDs may provoke side effects in the gastrointestinal system, when administered systemically, and, thus, they may not be suitable for some patients [99]. Topically applied NSAIDs are known to be safer in this regard than oral forms and they might be more effective [100,101].…”

The potential of lignocellulosic biomass for magnetic solid phase extraction of naproxen from saliva samples

“…29,30 Naproxen, a member of the propionic acid class of non-steroidal anti-inammatory drugs, is extensively employed to address both chronic and acute pain, fever, swelling, and inammation. [31][32][33] Numerous analytical techniques have been suggested for quantifying NSAIDs in biological uids and water matrices, 34,35 encompassing strategies for sample enrichment before applying liquid chromatography, gas chromatography, and capillary electrophoresis, or coupling with mass spectrometry. [36][37][38] However, it's worth noting that the majority of these techniques primarily focus on analyzing plasma or urine samples, with a limited number of methods tailored to saliva sample analysis.…”