A Romanian Population Isolate With High Frequency of Vitiligo and Associated Autoimmune Diseases

Birlea, Stanca A.; Fain, Pamela R.; Spritz, Richard A.

doi:10.1001/archderm.144.3.310

Cited by 74 publications

(62 citation statements)

References 22 publications

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“…25 We observed presence of family history in 10.6% of the cases, which amounts to the 9% reported in a Romanian population. 4 However, family history ranged from 34% to 38.7% in studies by other authors. 3.26 One can speculate that there was a higher frequency of this variable, especially in the study by Laberge et al, because it was conducted in a population in which several family members were affected by vitiligo, and there was also a more thorough investigation of these families.…”

Section: Discussionmentioning

confidence: 86%

“…21 However, data from previous studies show low prevalence, such as the values reported in a Chinese study that showed an association of 1.36% , 0.6% in Nigeria, 2.6% in Colombia and 3% in a Romanian population. 4 . It is noteworthy that in these studies the lower frequency of these diseases may have occurred due to their methodological characteristic, for laboratory tests were requested only when needed, that is, in the presence of symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Increased frequency of type 1 diabetes mellitus and scleroderma was not found. 3,4,7,21 The presence of autoimmune hepatitis or parotiditis was not cited in the literature. The increased frequency of autoimmune diseases in patients with vitiligo suggests that all these conditions share a common etiologic factor.…”

Section: Discussionmentioning

confidence: 99%

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Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Nunes

Esser

2011

An. Bras. Dermatol.

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BACKGROUND: Vitiligo is considered the most frequent acquired hypomelanosis. Although its pathogenesis is uncertain, it is believed that autoimmune etiology is the most plausible. This theory is based on the coexistence of vitiligo with autoimmune diseases. Objectives: To describe the epidemiological profile of vitiligo patients and to estimate the prevalence of the association of vitiligo with autoimmune thyroid diseases. Methods: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed with vitiligo in the AME-UNISUL Outpatient Clinic of Dermatology and at HU-UFSC. The clinical and laboratorial characteristics of these patients were assessed. Results: 85 medical records were evaluated; 56 patients were female, with a mean age of 37.14 years and mean onset age of 25.25 years. Vitiligo vulgaris occurred in 70.6%. Autoimmune thyroid diseases were found in 22.4%. Other autoimmune diseases were identified in 5.9%. Patients with positive thyroid autoantibodies showed a probability of extension of vitiligo greater than 25%. There was no statistical difference with regard to the clinical characteristics of vitiligo in patients with or without autoimmune thyroiditis with hormonal change. Conclusion: The findings of this study are similar to those obtained by other authors, showing that autoimmune thyroid diseases are more common in patients with vitiligo. Keywords: Autoimmunity; Thyroid diseases; Vitiligo Resumo: FUNDAMENTO: O vitiligo é considerado a hipomelanose adquirida mais frequente. Apesar de sua etiopatogenia ser incerta, acredita-se que a etiologia autoimune seja a mais plausível, teoria que se fundamenta na concomitância de vitiligo com doenças autoimunes. OBJETIVOS: Traçar o perfil epidemiológico dos pacientes com vitiligo e estimar a prevalência da associação de vitiligo com doenças autoimunes da tireoide. MÉTODOS: Efetuou-se um estudo transversal, analisando-se prontuários dos pacientes com diagnóstico de vitiligo atendidos no Ambulatório de Dermatologia AME-Unisul e do HU-UFSC. Avaliaram-se as características clínicas e laboratoriais desses pacientes. RESULTADOS: Foram avaliados 85 prontuários, sendo 56 do sexo feminino, com idade média de 37,14 anos e idade média de início de 25,25 anos. O vitiligo vulgar ocorreu em 70,6% dos casos. As doenças autoimunes da tireoide foram encontradas em 22,4% dos casos. Outras doenças autoimunes foram identificadas em 5,9% dos casos. Os pacientes com anticorpos antitireoidianos positivos revelaram uma probabilidade elevada de extensão do vitiligo maior que 25%. Não houve diferença estatística quanto às características clínicas do vitiligo em portadores ou não de tireoidite autoimune com alteração hormonal. CONCLUSÃO: Os resultados deste estudo são similares aos de outros autores, mostrando que as doenças autoimunes da tireoide são mais frequentes nos pacientes com vitiligo.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Nunes

Esser

2011

An. Bras. Dermatol.

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“…Table 3. Disorders associated with vitiligo (Alkhateeb et al, 2003;Birlea et al, 2008;Bolognia et al, 2008;Burn's et al, 2004;Daneshpazhooh et al, 2006;James et al, 2006;Lebwohl et al, 2006;Pichler et al, 2009;Yaghoobi et al, 2011b;Zhang et al, 2009) …”

Section: Association Between Vitiligo and Other Disordersmentioning

confidence: 99%

“…Vitiligo was first described more than 3,000 years ago in pre-Hindu Vedic and ancient Egyptian texts (Mahmoud et al, 2008;as cited in Millington& Level, 2007). It has been introduced based on its visual phenotype (Yaghoobi et al, 2011a,b; as cited in Birlea et al, 2008;. Studies have shown that approximately 20% of vitiligo patients have at least one first-degree relative with this disorder; so, it seems that the relative risk for first-degree relatives of vitiligo patients is increased by 7-to 10-fold (Wolff et al, 2007;Yaghoobi et al, 2011b).…”

Section: Introductionmentioning

confidence: 99%

Role of Corticosteroids in Treatment of Vitiligo

Bagherani¹

2012

State of the Art of Therapeutic Endocrinology

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Genetics of Vitiligo

Roberts¹,

Spritz²

2018

Encyclopedia of Life Sciences

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Vitiligo is an autoimmune disease that results in destruction of skin melanocytes and patches of white skin and hair. Family studies of vitiligo demonstrated that a strong, but complex genetic component underlies disease risk and that vitiligo often occurs with other autoimmune diseases, suggesting shared autoimmune susceptibility. Genome‐wide linkage and association studies have identified over 50 vitiligo susceptibility loci, with most loci harbouring genes involved in immune regulation, apoptosis or melanocyte function. The identified loci fit together in a model of melanocyte‐directed autoimmunity, and many loci are shared with other autoimmune diseases. Surprisingly, some genetic vitiligo susceptibility alleles are inversely associated with melanoma, suggesting that vitiligo represents enhanced immune surveillance against melanoma. Genetic studies of vitiligo have greatly advanced understanding of vitiligo pathobiology and may additionally provide insights into melanoma and other autoimmune disease. Key Concepts Vitiligo is a multifactorial disease, in which multiple genetic and environmental factors contribute to disease risk. The genetic architecture of vitiligo is typically (and perhaps always) polygenic, with a strong genetic component underlying disease risk. Over 50 genetic loci have been associated with vitiligo risk; these loci fit together in a model of melanocyte‐directed autoimmune pathobiology. Most variants associated with vitiligo are in noncoding regions and presumably affect gene regulation. Nevertheless, some associated coding variants and physical interaction among proteins encoded by some vitiligo susceptibility genes provide special insights into pathogenesis. Vitiligo shares many genetic risk factors with other autoimmune diseases with which it is epidemiologically associated, supporting a component of common autoimmune pathogenesis.

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A Romanian Population Isolate With High Frequency of Vitiligo and Associated Autoimmune Diseases

Cited by 74 publications

References 22 publications

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Role of Corticosteroids in Treatment of Vitiligo

Genetics of Vitiligo

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