2002
DOI: 10.1152/ajpregu.00200.2002
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: tion attenuated anorexia after lipopolysaccharide (LPS) administration, we tested the ability of resveratrol (2.5, 10, and 40 mg/kg) and NS-398 (2.5, 10, and 40 mg/kg), selective inhibitors of the two COX isoforms COX-1 and -2, respectively, to attenuate LPS (100 g/kg ip)-induced anorexia. NS-398 (10 and 40 mg/kg) administered with LPS at lights out attenuated LPS-induced anorexia, whereas resveratrol at all doses tested did not. Because prostaglandin (PG) E2 is considered the major metabolite synthesized by C… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
58
0
3

Year Published

2005
2005
2015
2015

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 79 publications
(64 citation statements)
references
References 41 publications
3
58
0
3
Order By: Relevance
“…Sickness syndromes such as fever, activation of the hypothalamopituitary adrenal axis, and anorexia occurs in response to peripheral administration of LPS [14][15][16]. It is interesting that LPS-induced anorexia is not related Fig.…”
Section: Lps-induced Anorexiamentioning
confidence: 99%
“…Sickness syndromes such as fever, activation of the hypothalamopituitary adrenal axis, and anorexia occurs in response to peripheral administration of LPS [14][15][16]. It is interesting that LPS-induced anorexia is not related Fig.…”
Section: Lps-induced Anorexiamentioning
confidence: 99%
“…macrophages, fibroblasts), estimated to be limited to approximately 10% of all mammalian cells, while COX-2 is transiently expressed, probably in all cells during replication/differentiation (Smith et al, 2011) and also during inflammation/cellular stress (Dubois et al, 1998). Of the two enzymes, inducible COX-2 was demonstrated to be necessary for the sickness syndrome Lugarini et al, 2002). Brain COX-2 was found to be constitutively expressed in neurons (Breder et al, 1995;Yamagata et al, 1993) and reported to be induced by immune stimuli in vascular cells (Cao et al, 1995), and PVCs (Breder and Saper, 1996) but also in neurons by e.g.…”
Section: Prostaglandinsmentioning
confidence: 99%
“…While being reversed by COX-2 inhibitors (Johnson et al, 2002;Lugarini et al, 2002), the anorectic response driven by inflammation-induced PGE2 is dependent on the type of immune stimuli. Hence, IL-1β initiated a PGE2-dependent anorexia in contrast to LPS, which seems to be PGE2-independent (Elander et al, 2007;Pecchi et al, 2006).…”
Section: Anorexiamentioning
confidence: 99%
“…Ainsi, au niveau central, la synthèse de la prostaglandine de type E2 (PGE2) à partir de l'acide arachidonique augmente de façon considérable lors d'une infection et son rôle causal dans la mise en place des symptômes du illness behavior a été établi voilà plusieurs années par différents groupes [2,3,13]. Une des stratégies théra-peutiques anti-inflammatoires parmi les plus anciennes consiste à bloquer la production de ces composés via l'inhibition des enzymes cyclo-oxygénases (COX) dont deux principales isoformes sont actuellement identifiées : COX-1 et COX-2.…”
Section: Magazineunclassified
“…Présent de manière constitutive dans le cytosol, l'hétérodimère NF-κB (le plus souvent p65/p50) est séques-tré par son inhibiteur IκBα qui masque sa séquence de localisation nucléaire [2,3]. L'activation de NF-κB repose sur la mise en place de plates-formes multiprotéiques spécifiques d'un stimulus dont la fonction est de recruter et rendre compétent le complexe IKK (inhibitor of NF-kB kinase).…”
Section: Nouvelleunclassified